RESUMO
Objective: To explore the contribution of cytochrome P450 (CYP) 1A1z.ast;2C polymorphism to susceptibility to acute lymphoblastic leukemia (ALL) in children. Methods: The case-control studies involving the association of CYP1A1z.ast;2C polymorphism with the susceptibility to childhood ALL were retrieved through computer-based search in PubMed, Embase, Ovid, China Journal Full-text Database, Chinese Biomedical Literature Data, China National Knowledge Infrastructure and Wanfang Database. The statistical analysis was performed by STATA 12.0 software. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated, and the subgroup ananlysis, sensitivity analysis and publication bias were also carried out. Results: A total of seven eligible case-control studies were included for analysis. The Meta analysis revealed that there was a significant association of CYP1A1z.ast;2C ploymorphism with risk of childhood ALL (C vs A: OR = 1.20, 95% CI: 1.01-1.43; GG vs AA: OR = 1.73, 95% CI: 1.1 1-2.70; GG vs AG + AA: OR = 1.68, 95% CI: 1.09-2.59). In a subgroup in which the controls were hospitalized in the same period as the cases hospitalized, there was also a significant association of CYP1A1z.ast;2C ploymorphism with risk of childhood ALL (G vs A: OR = 1.29, 95% CI: 1.04-1.59; GG vs AA: OR = 1.89, 95% CI: 1.15-3.10; GG vs AG+AA: OR = 1.83, 95% CI: 1.14-2.94). After excluding a study with high heterogeneity, the sensitivity analysis showed no significant association between CKP1A1z.ast;2C ploymorphism and childhood ALL. Conclusion: The results of this Meta analysis suggest that CYP1A1z.ast;2C polymorphism may be not significantly associated with the susceptibility to childhood ALL.
RESUMO
<p><b>OBJECTIVE</b>To explore the association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia (ALL) through a Meta analysis.</p><p><b>METHODS</b>Inclusion and exclusion criteria were formulated and English and Chinese databases (PubMed, OVID Database, CBM, CNKI, and Wanfang Data) were searched comprehensively. The studies (from January 1999 to April 2015) related to the association between CYP1A1*2A polymorphism and susceptibility to childhood ALL were collected. STATA 12.0 Software was applied to perform the Meta analysis for the articles included.</p><p><b>RESULTS</b>A total of 12 articles were included for analysis (11 English articles and 1 Chinese article), which involved 3 355 cases in total. The results of the Meta analysis showed a significant association between CYP1A1*2A polymorphism and susceptibility to childhood ALL (allele model: OR=1.31, 95% CI: 1.07-1.61; dominant model: OR=1.33, 95% CI: 1.13-1.56; codominant model: OR=1.30, 95% CI: 1.10-1.54). According to the results of a subgroup analysis based on ethnic origin, an increased risk of childhood ALL was observed in both Asian subgroup (dominant model: OR=1.57, 95% CI: 1.19-2.08; codominant model: OR=1.61, 95% CI: 1.20-2.17) and the Caucasian subgroup (allele model: OR=1.31, 95% CI: 1.04-1.63; dominant model: OR=1.22, 95% CI: 1.00-1.49).</p><p><b>CONCLUSIONS</b>CYP1A1*2A polymorphism may be associated with the genetic susceptibility to childhood ALL.</p>