Simple Uv zero-order and derivative spectrophotometric analysis of amprolium hydrochloride and ethopabate in veterinary premixes

In this work, simple, sensitive and accurate zero-order and derivative spectrophotometric methods have been developed for the determination of amprolium hydrochloride and ethopabate in admixture in veterinary premixes. The first method was based on the free solubility of the low constituent, ethopabate, in chloroform and the absorbance was measured at 267 mn. On the other hand, amprolium hydrochloride in the residue left was dissolved in 0.1 M hydrochloric acid and its absorbance was measured at 248 mn. The second method depended upon extracting the two drugs from their formulations using 0.1 M hydrochloric acid and the amplitude of the second derivative was measured at 279 nm for amprolium hydrochloride analysis and the amplitude of the first derivative of the valley was measured at 315 nm for ethopabate. These two methods allowed the simultaneous assay of amprolium hydrochloride and ethopabate in chicken feed in much shorter analysis time with good accuracy and precision

Utility of potassium iodate for the estimation of lornoxicam, meloxicam and sulbutiamine in pharmaceutical formulations

In this study, a simple and accurate method was described for the determination of lornoxicam, meloxicam and salbutiamine. The method involved the oxidation of drugs with potassium iodate in acidic medium with the liberation of iodine. The liberated iodine was extracted into cyclohexane and the absorbance was measured at 520 nm. The effect of different experimental parameters on the development of the color was studied [the concentration of the reagent, temperature and reaction time]. The method was applicable over a concentration range of 0.10-0.50, 0.05-0.30 and 0.05-0.40 mg ml-1 for lornoxicam, meloxicam and salbutiamine, respectively. The proposed method was successfully applied to the determination of the studied drugs in bulk powder and in the pharmaceutical dosage forms. The validity of the method was assessed by applying the standard addition technique