Effects of lipid emulsion on acute liver injury induced by trichloroethylene in male rats / 中国职业医学

OBJECTIVE: To investigate the effects of lipid emulsion on acute liver injury induced by trichloroethylene( TCE)in male rats. METHODS: By random number table method,18 specific pathogen free male rats were randomly divided into control group,TCE exposure group and lipid emulsion intervention group,6 rats in each group. The rats of TCE exposure group and lipid emulsion intervention group were given TCE 3 g / kg body weight by intragastric administration,and rats in control group were given the same amount of peanut oil. Rats in lipid emulsion intervention group were given 20% lipid emulsion( 2 mL / kg body weight) by intravenous injection,and the same amount of 0. 9% sodium chloride solution was given by intravenous injection in control group and TCE exposure group. After 24 hours,the activities of alanine aminotransferase( ALT) and aspartate aminotransferase( AST) in serum. Some liver tissues were used for pathological analysis; some for 10% liver homogenate and the levels of malondialdehyde system( MDA),superoxide dismutase( SOD)and glutathione peroxidase( GSH-Px) were detected. RESULTS: Compared with TCE exposure group,edema of liver cell in lipid emulsion intervention group was significantly reduced. Compared with the control group and the lipid emulsion intervention group,the activities of ALT and AST in serum,and the levels of MOD and SOD in liver homogenate were increased( P < 0. 05). The above 4 indexes in the lipid emulsion intervention group were increased compared with the control group( P < 0. 05). There is no significant difference in GSH-Px level in all three groups( P > 0. 05). CONCLUSION: Administration of lipid emulsion can alleviate TCE-induced acute liver damage in rats through improving the lipid peroxidation mechanism.

N400 elicited by incongruent ending words of Chinese idioms in healthy adults / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Prior research about N400 has been mainly based on English stimuli, while the cognitive processing of Chinese characters is still unclear. The aim of the present study was to further investigate the semantic processing of Chinese idioms.</p><p><b>METHODS</b>Event related potentials (ERP) component N400 was elicited by 38 pairs of matching (congruent) and mismatching (incongruent) ended Chinese idioms: ending words with same phoneme but different shape and meaning (sPdSdM), with similar shape but different phoneme and meaning (sSdPdM), with same meaning but different phoneme and shape (sMdPdS), and words with different phoneme, shape and meaning (dPdSdM) and recorded by Guangzhou Runjie WJ-1 ERP instruments. In 62 right-handed healthy adults (age 19 - 50 years), N400 amplitudes and latencies were compared between matching and mismatching conditions at Fz, Cz and Pz.</p><p><b>RESULTS</b>N400 showed a midline distribution and could be elicited in electrodes Fz, Cz and Pz. The mean values of N400 latencies and amplitudes were obtained for matching and mismatching ending words in healthy adults. Significant differences were found in N400 latencies and amplitudes in matching and mismatching ending-words idioms in healthy adults (P < 0.05). Compared with matching ending-words idioms, N400 latencies were prolonged and the amplitudes were increased in mismatching ones. N400s elicited by different types of stimuli showed different latencies and amplitudes, and longest N400 latency and largest N400 amplitude were elicited by ending-words with dPdSdM. No gender difference was found of N400 latency and amplitude in this study (P > 0.05).</p><p><b>CONCLUSIONS</b>Compared with English stimuli, Chinese ideographic words could provide more flexible stimuli for N400 research in that the words have 3-dimension changes - phoneme, shape and meaning. Features of N400 elicited by matching and mismatching ending words in Chinese idioms are mainly determined by the meaning of the word. Some issues of N400 elicited by Chinese characters deserve further research.</p>

Immunohistochemical study of heme oxygenase-1 expressed in human normal dental pulp cell and tissue / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To study the expression of heme oxygenase-1 (HO-1) in dental pulp tissue and to find out the relationship of distribution and function of HO-1.</p><p><b>METHODS</b>30 pulp tissues were obtained from clinically extracted human healthy premolars and third molars. The expression of HO-1 in dental pulp was detected by means of SABC immunohistochemical technology.</p><p><b>RESULTS</b>HO-1 immunoreactivity was observed in vascular endothelial cells, odontoblasts and some fibroblasts cells.</p><p><b>CONCLUSION</b>The distribution of HO-1 in normal human dental pulp suggests that HO-1 may play an important role in pulp flow regulation, dentin production and its calcifying; it also may play some roles in dental pulp cells metabolism and differentiation.</p>

Applied research of intermaxillary fixation screw in the jaw fracture / 中华整形外科杂志

<p><b>OBJECTIVE</b>To evaluate and generalize the application of intermaxillary fixation screw in the jaw fracture.</p><p><b>METHODS</b>41 cases of jaw fracture have been treated with intermaxillary fixation screw.</p><p><b>RESULTS</b>Both function and appearance have recuperated in 40 cases except 1 case has light malocclusion.</p><p><b>CONCLUSIONS</b>Application of intermaxillary fixation screw advanced the traditional therapy.</p>