RESUMO
<p><b>OBJECTIVE</b>To determine the expression and possible function of CIC-5 during the rat tooth germ development.</p><p><b>METHODS</b>Isolated total mRNA and protein from the rat tooth germs which were at different stages of development. RT-PCR and Western blot were used to investigate the mRNA and protein expression of the CIC-5 in the rat tooth germ.</p><p><b>RESULTS</b>The mRNA and protein of CIC-5 expressed in the late bell stage, but undetected inThe mRNA and protein of CIC-5 expressed in the late bell stage, but undetected in the early or middle bell stage.</p><p><b>CONCLUSION</b>These results showed the spatial temporal distribution of expression of CIC-5 during the different stages of the rat tooth germ development and suggested that it might contribute to the rat tooth germ development.</p>