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1.
Zhongguo Zhong Yao Za Zhi ; (24): 2975-2978, 2015.
Artigo em Chinês | WPRIM | ID: wpr-284815

RESUMO

To determine the optimum process conditions for dry granulating technique of Qibai Pingfei granule, granule excipient type, rolling wheel speed and pressure and feeding speed were studied. Taking shaping rate at a time, moisture absorption and dissolubility as index, the type and amount of granule excipient were determined. In addition, taking shaping rate at a time as index, parameters of rolling wheel speed and pressure and feeding speed were researched through single factor test and response surface methodology. The optimum parameters were as follows: lactose as excipient, dry extract powder to excipient at 1:2, rolling wheel speed and pressure at 10.9 Hz and 6.4 MPa and feeding speed at 7.2 Hz. After validation of three batches pilot-scale production, the optimum processing parameters for dry granulating technique of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.


Assuntos
Medicamentos de Ervas Chinesas , Pós , Tecnologia Farmacêutica , Métodos
2.
Zhongguo Zhong Yao Za Zhi ; (24): 3987-3992, 2015.
Artigo em Chinês | WPRIM | ID: wpr-320803

RESUMO

Based on single factor tests,the optimum vacuum belt drying conditions of Qibai Pingfei granule were obtained through Box-Benhnken central combination design and RSM. In this study, drying time, drying temperature and extract density were chosen as independent variables, while transferring rate ginsenoside Rg₁, Re, Rb₁and astragaloside IV were taken as dependent variables. The optimum parameters are as follows: drying time of 112 min, drying temperature of 87 °C and extract density of 1.30 g · mL⁻¹. At the optimum condition, transferring rate ginsenoside Rg₁+ Re, Rb₁and astragaloside IV were 88.01%, 87.31%, 84. 34%. Above all, the optimum processing parameters of vacuum belt drying of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.


Assuntos
Química Farmacêutica , Métodos , Dessecação , Métodos , Medicamentos de Ervas Chinesas , Química , Plantas Medicinais , Química , Controle de Qualidade , Temperatura , Vácuo
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