Using a risk-based approach in national chemical management programs:challenges and opportunities / 中国药理学与毒理学杂志

Although che mical manage ment progra ms have been in place in several countries for more than 30 years they continue to be chal enged by factors such as data quality and quantity,greater de mand on regulatory staff and re-sources,an evolution in hazard and exposure assess ment methods,and continued debate about manage ment progra ms that are risk-based (hazard and exposure)or hazard-based.Countries developing their own che mical manage ment pro-gra ms often wish to learn fro m the experience of others,and thereby have progra ms that either reduce or eli minate so me of the proble ms associated with existing progra ms.However,often even new progra ms face the sa me or new proble ms that have been associated with managing che micals.In this paper we su mmarize so me of the ele ments of existing pro-gra ms in the United States and Europe,the developing progra m in China,and the chal enges associated with the evolution of hazard,exposure and risk assess ment methods.We conclude by suggesting areas where further research may be use-ful for i mproving che mical manage ment progra ms.

Effect of TGF-β on collagen degradation of rabbit keratocytes / 吉林大学学报(医学版)

Objective:To observe the effect of TGF-β1 on collagen degradation of rabbit keratocytes.Methods:The activity of collagen degradation of keratocytes with three-dime nsional culture in collagen gel was determined with spectrophotometer.Results:TGF-β inhibited collagen degradation of keratocytes in dose-dependent manner.Conclusion:The present result suggests that TGF-β1 has the inhibitory effect on collagen degradation of keratocytes and may help in the treatment of corneal ulceration.