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Objective To investigate the effect of rehabilitation training on learning and memory ability and the expression of neural cell adhesion molecule(NCAM)in rats modeling vascular dementia.Methods Foay-five female Sprague-Dawley rats were randomly assigned to a rehabilitation group(20 rats),an immobilization group(20 rats),or a sham-operation group(5 rats).The experimental vascular dementia model was established by repeatedly clipping the common carotid artery to induce repetitive isehemia-reperfusion,and by reducing blood pressure with intra-abdominal injection of sodium nitroprusside.The rats' learning and memory were tested on the 27th and 28th days after the operation using a water-maze step-down avoidance test.A RT-PCR technique was used to detect NCAM expression around the hippocampal area at different times after the operation.Results The rehabilitation group rats showed significantly better learning and memory ability than those in the immobilization group.NCAM was also more strongly expressed in their hippocampi than in those of the immobilization group and sham-operation group.Conclusion Rehabilitation can accelerate recovery of learning and memory ability in rats,and the mechanism possibly is related to the increase of NCAM expression in the hippocampus.
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Objective To study the effects of rehabilitation training on learning and memory ability and the expression of growth-associated protein-43(GAP-43)in rats with vascular dementia.Methods Forty-four female Sprague-Dawley rats were randomly assigned to a rehabilitation group(n=20),an immobilization group(n=20),and a sham-operation group(n=4).The rats in the former 2 groups were operated on to establish the experimental vascular dementia model by repeatedly ischemia/reperfusion injury of brain induced by ligation of bilateral common carotid arteries and lowering of blood pressure induced by intraabdominal injection of sodium nitroprusside.The rats in rehabilitation group were administered with rotating bar and rolling cage exercises for 1 hour once daily,while those in the immobilization group were immobilized and without any exercise:the rats in sham-operation group could move freely in cage.Learning and memory tests were preformed by using step-down avoidance test at the 27th and 28th days after operation.Immunohistochemical staining was used to detect GAP-43 expression in hippocampus CA1 area at different time points after operation. Results The rats in rehabilitation group demonstrated better learning and memory ability than those in immobilization group(P<0.01),and more GAP-43 expression in hippocampus CA1 ar-ea than those in immobilization group and sham-operation(P<0.01).Conclusion Rehabilitation training can im-prove the learning and memory ability of rats with experimental vascular dementia,and the mechanism is probably re-lated to the increase of GAP-43 in hippocampus CA1 area.
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@#The development of education in rehabilitation medicine in China were analyzed and some solutions were suggested: increasing the investment in rehabilitation education; strengthening the teaching staff to improve the quality of teaching; establishing a standardized vocational system; intensifying the rehabilitation education for medical students.
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Objective To study the effect of con tinuous passive motion (CPM) on joint function after arthroscopy in the knee jo int. Methods Arthroscopy examinations and operations were performed in 53 patients. They were divided into study and control groups based on the use or not of CPM immediately in the postoperative period. The cont rol group consisted of 25 patients treated without postoperative CPM and the stu dy group consisted of 28 patients treated with CPM postoperatively. Range of mot ion (ROM) and the comprehensive function score of the knee joint were evaluated preoperatively, at discharge and at three months after operation. Results There were statistically significant differences in the f unction score of the knee joint between the two groups at discharge. The mean f lexion and extension in the study group were 90.64??16.57? and -0.71??3.78 ?, respectively, compared to 69.40??15.17? and -4.32??4.71? in the contro l group. The mean of the comprehensive function score of the knee joint in the c ontrol group were 11.24.compared to 8.89 in the study group. Seventy-five perce nt (21 cases) of the patients in the CPM group and 24% (6 cases)of patients in t he control group had achieved 90? of flexion at the time of hospital discharge. Conclusion CPM had enhanced the therapeutic effects of arthroscopy in the knee joint and shortened the length of stay of the patie nts in the hospital. Further investigation is needed for evaluating the long-te rm effect of CPM.