RESUMO
Pulmonary fibrosis is the late stage of many lung diseases. It′s a pathological process with excessive deposition of extracellular matrix, tissue scar formation and lung tissue remodeling. Recently, DNA methylation has been demonstrated to involve in organ fibrosis, includingpulmonary, liver, renal fibrosis and so on. DNA methylation plays an important role in clinical diagnosis and treatment. This article reviews the role of DNA methylation in the development of pulmonary fibrosis and discusses thepathogenic mechanism of pulmonary fibrosis and new anti-fibrotic strategy.
RESUMO
Pulmonary fibrosis is the late stage of many lung diseases. It′s a pathological process with excessive deposition of extracellular matrix, tissue scar formation and lung tissue remodeling. Recently, DNA methylation has been demonstrated to involve in organ fibrosis, includingpulmonary, liver, renal fibrosis and so on. DNA methylation plays an important role in clinical diagnosis and treatment. This article reviews the role of DNA methylation in the development of pulmonary fibrosis and discusses thepathogenic mechanism of pulmonary fibrosis and new anti-fibrotic strategy.
RESUMO
High-fat diet has led to rapid increase in population withdyslipidemia due to the improvement of living standard, which has seriously endangished people′s health.Blood lipid examination is the an important method to diagnose and monitordyslipidemia.Precision detection and proper management can effectively help doctor to diagnose and treat dyslipidemia.This article mainly introduced international and domestic guidelines about dyslipidemia and related progress as well as highlightin this field.Meanwhile, we provided several advices on dyslipidemia from various perspectives.Clinical laboratory related personnel should analyze the influenced factors on blood lipid test examination at pre-test, on-test and post-test and providebetter detection and managementfor blood lipid.