Research progress in diagnosis and treatment of cystitis glandularis / 国际外科学杂志

Cystitis glandularis is a hyperplastic disease originated from the bladder mucosa, cystitis glandularis is a rare clinical disease, there is no standard diagnosis and treatment. The etiology and pathogenesis of cystitis glandularis are still unknown, it can be diagnosed according to clinical manifestations, laboratory and auxiliary examinations, and the diagnosis of cystitis glandularis mainly depends on pathological results. Cystitis glandularis has a cancerous tendency. The clinical treatment methods of cystitis glandularis include conservative treatment, surgical treatment and surgical combined with drug therapy, but different types of treatment methods are different, and most patients are treated by surgery combined with drug perfusion of the bladder.This article will review the research progress in diagnosis and treatment of cystitis glandularis.

Progress in the diagnosis and treatment of adrenal metastatic carcinoma / 国际外科学杂志

Adrenal gland is one of the most common metastases from malignant tumors. Most adrenal metastases have not completely destroyed adrenal tissue, so most patients have no clinical symptoms. The main methods for the diagnosis of adrenal metastases are CT, magnetic resonance imaging and positron emission tomography. At present, there is still controversy about the treatment of adrenal metastasis of all kinds of adrenal metastases. Non-surgical treatment mainly includes chemical drug therapy, radiotherapy, interventional therapy and so on. With the development of cognition and technology, the mode and indication of surgical treatment have also changed. In this paper, the diagnosis and treatment of adrenal metastases in recent years are reviewed.

Effect of honokiol on proliferation, migration and apoptosis of human tongue cancer CAL-27 cells / 南方医科大学学报

OBJECTIVE@#To study the effects of honokiol on proliferation, migration and apoptosis of human tongue carcinoma CAL-27 cells.@*METHODS@#Routinely cultured CAL-27 cells were treated with 20, 40, or 60 μmol/L honokiol and the changes in cell proliferation were assessed with MTT assay. The scratch wound healing assay was used to assess the migration ability of the treated cells, and the cell apoptosis was detected with Hoechst33342 fluorescence staining and annexin V-FITC/PI method. The protein expression levels of p-Pi3k, p-Fak, Fak, MMP-2, MMP-9, p-Akt, Akt, Bax, Bcl-2 and cleaved-caspase-3 in the treated cells were detected using Western blotting.@*RESULTS@#Treatment with honokiol at 20, 40, and 60 μmol/L for 24 h significantly lowered the proliferation and migration ability of CAL-27 cells. The number of apoptotic cells increased with the increase of honokiol concentration, which resulted in a cell apoptosis rate of (15.24±2.06)% at 20 μmol/L, (35.03±2.42)% at 40 μmol/L, and (48.13±4.61)% at 60 μmol/L, as compared with (6.53±1.80)% in the control group. The expressions of p-Pi3k, p-Fak, MMP-2, MMP-9, p-Akt and BCL-2 decreased and those of Bax and cleaved-caspase-3 increased significantly in the cells after the treatment ( < 0.01).@*CONCLUSIONS@#Honokiol can inhibit the proliferation and migration and induce apoptosis of CAL-27 cells possibly by regulating the expressions of p-Pi3k, p-Fak, MMP-2, MMP-9, p-Akt, Bax, Bcl-2 and cleaved-caspase-3.

Prevalence of myopia among primary and middle school students in Longkou City, Shandong Province / 国际眼科杂志(Guoji Yanke Zazhi)

·AIM: To investigate the prevalence of myopia among primary and middle school students aged 7 to 18 in Longkou City, Shandong Province, and to provide a scientific basis for prevention and control of myopia. ·METHODS: The students aged 7 to 18 were enrolled through the method of stratified random and cluster sampling by the unit of schools and were investigated in Longkou, Shandong Province in 2015. A total of 58 schools were selected and 61 036 students were effectively sampled. All the subjects were divided into three- tiers based on geographical location: urban, rural-urban continuum, and rural areas. All the subjects were examined with the visual acuity and non -cycloplegic objective fraction. Microsoft Excel worksheet was used to establish a database, and SPSS 21. 0 software was used for statistical analysis. ·RESULTS: The prevalence of total myopia in the sample population of students of Longkou in 2015 was 49. 81% from 7 to 18 years old. The overall prevalence of myopia increased fastest from 11 to 12 years old. And the prevalence of mild myopia of students aged 13 was highest. The prevalence of total myopia were 46. 41% for boys and 53. 39% for girls, which showed the prevalence of girls was higher than the boys'. The prevalence of myopia in urban, rural- urban continuum, and rural areas were 55. 18% , 49. 75% , 44. 47% , respectively, and the prevalence of myopia in urban areas was the higher than the rural-urban continuum and the rural areas. The prevalence of total myopia gradually increased with age (rs=0. 943, P<0. 05). ·CONCLUSION: The results of the investigation showed a high prevalence of myopia among primary and middle school students in the city of Longkou, and gradually increased with age. The overall myopia prevalence for girls was higher than boys, and the prevalence was highest in urban areas.

Influence of Convergence Angle and Cement Space on Margin and Internal Adaptation of CAD/CAM All-ceramic Crowns / 中国医科大学学报

Objective To study the influence of the convergence angle and cement space on the fit of CAD/CAM all-ceramic crowns.Methods The PMMA resin was produced in two groups,group A (2 degrees) and group B (4 degrees),30 in each group,and each group was divided into 3 sub-groups A 1,A2,A3;or B 1,B2,B3.Each subgroup included 10 patients with a CAD/CAM all-ceramic crown with PMMA resin generation type,but the cement space was 40 μm,60 μm,or 80 μm.The internal clearance edge of the double color silicone rubber impression reproduction technology of the all-ceramic crown was observed under the microscope.Analysis Micro-image software was used to measure the edge gap,and the resulting data were analyzed using SPSS 20.0 software.Results When the cement space is the same,the difference between 2 degrees and 4 degrees was statistically significant.Conclusion The fit is the best when the cement space is 60 μm and the convergence angle space is 4 degrees.

Effect of Adhesive Overflow Grooves on the Adaptation of a Molar Zirconia Full Crown / 中国医科大学学报

Objective To study the effect of adhesive overflow grooves on the marginal and internal adaptation of a molar zirconia full crown.Methods A three-dimensional model of a mandibular first molar was established.Four crown preparations (A-D) were designed:a was a conventional full crown design,and B,C,and D included 1,2,and 4 adhesive overflow grooves,respectively,designed on the basis of A.Five resin preparations were created for each group using three-dimensional (3D) printing.According to the a design data,20 CAD/ CAM zirconia crowns were prepared and randomly divided into four groups.The tooth,preparations,and crowns underwent 3D scanning for 3D deviation analysis and 3D wall thickness analysis.The gap between the crown and the preparation was replicated with silicone rubber,and then observed with a metallographic microscope and measured.Data were statistically analyzed with SPSS 17.0.Results Among the groups,marginal and internal clearance was A＞B＞C＞D.The comparison between every two groups was statistically different (P ＜ 0.05).Conclusion Increases in the number of overflow grooves result in significant increases in the marginal adaptation and internal adaptation of a full crown.

The Occluding Effect of Penetrating Resin Combined with Ethanol Wet-bonding on Dentin Tubule / 中国医科大学学报

Objective To compare the occluding effect of conventional penetrating resin,Single Bond desensitizer,and penetrating resin combined with ethanol wet-bonding on dentin tubules.Methods Sixty isolated premolar teeth were prepared to form dentin discs.The 60 teeth were divided into 3 groups based on a random number table:Group A,conventional penetrating resin;Group B,Single Bond desensitizer,and Group C,penetrating resin combined with ethanol wet-bonding.Each group comprised 20 teeth.Dentin discs were split in half along the longitudinal axis.Half of the disc served as the control;the other half was coated with desensitizer.Microscopic characteristics of the dentin surface and profile were determined by using a field emission scanning electron microscope.Results In group A,70.10％±2.13％ of the dentin tubule openings were covered by the resin.The penetration depth was 50±10.59 μm,and the resin was short and discontinuous.In group B,86.35％±1.73％ of the dentin tubules openings were covered.The penetration depth was 69± 11.98 μm,and the resin was sparse.In group C,95.65％± 1.46％ of dentin tubules openings were covered.The penetration depth was 177±9.17 μm,and the resin was compact and filled.Conclusion Penetrating resin combined with ethanol wet-bonding occludes dentin tubules better than conventional penetrating resin and Single Bond desensitizer.

Study on expression and correlation of Rac1 and E-cadherin protein in oral squamous cell carcinoma / 天津医药

Objective To investigate the expression levels of Rac1 and E-cadherin and their correlation in oral squamous cell carcinoma, and to explore their relations to clinical pathological parameters. Methods The expression levels of Rac1 and E-cadherin were detected in 22 samples of oral squamous cell carcinoma and 8 samples of para-carcinoma tissue by using immunohistochemistry technique (SP). The patients were divided into two groups according to the clinicopathological parameters. The differences of Rac1 and E-cadherin expression levels were analyzed between the groups. Results The positive expression rates of Rac1 were 1/8 and 77.3%(17/22) in para-carcinoma tissue and oral squamous cell carcinoma, respectively. The difference was statistically significant (P=0.003). The positive expression rates of E-cadherin were 8/8 and 31.8%(7/22), and there was a difference between them (P=0.002). The Rac1 protein expression rate was increased and E-cadherin was decreased in oral squamous cell carcinoma. There were no significant differences in Rac 1 and E-cadherin between different age and gender groups. There was significant difference in Rac1 expression between patients with metastasis and patients without metastasis (P=0.021). While there was no difference in E-cadherin expression between patients with metastasis and patients without metastasis. No correlation was found between Rac 1 and E-cadherin expressions in oral squamous cell carcinoma. Conclusion The high expression of Rac1 and low expression of E-cadherin may play an important role in the tumorigenesis and progression of oral squamous cell carcinoma.

Effects of Different Materials Post-core Restoration on Fracture Resistance of Weakened Roots / 中国医科大学学报

Objective To investigate the influence of different kinds of post?core materials on fracture resistant ability of different walls during weakened root restoration. Methods Forty?eight human single root mandibular first premolars were randomly assigned to two groups(groupⅠwas repaired with quartz?fiber post?core and mental crown ,and groupⅡwas repaired with Co?Cr cast metal post?core and mental crown). Each main group was then divided into four subgroups of 6 specimens. All samples were tested on the universal test machine. We observed the fracture load and the fracture mode of the specimens. Results Cr?Co ally post?core group exhibited significantly higher resistance to fracture than quartz fiber post?core in the same number weakened root walls(P<0.05). With the increase in the quantity of weakened root walls ,the fracture resistance was significant decreased in the same post?core material(P<0.05). The possibility of repairable fractures in groupⅠwas significantly higher than that in groupⅡ(P<0.05). Conclusion Cr?Co alloy post?core can bear a higher bite ,but quartz fiber post?core has the most favorable fracture modes.

Effects of direct and indirect repair methods on microleakage in weak anterior teeth root canals / 天津医药

Objective To compare the difference of the microleakage repaired by direct method and indirect method of the funnel shaped root canal in the anterior teeth. Methods A total of 22 middle teeth at the similar size were collected, prepared into funnel root canal after finishing the root filling. The teeth were divided into A and B groups randomly, and there were 11 test pieces in each group. The root canal was repaired by direct method in group A and indirect method in group B. After 500 thermal-cold cycling and 240 000 dynamic cyclic loading,one tooth was selected in each group randomly. The microstructure were observed by scanning electron microscope (SEM). One piece of each group was randomly selected and the image of the core and the dentin was scanned by electron microscope. The remaining 20 pieces were dyed by India ink, dealt with transparent, compared and observed under the microscope. The degree of microleakage was recorded and analyzed in two groups. Results Under electron microscope, a gap can be observed in the bonding interface of group A. The gap was significantly bigger than that of group B. The leakage was significantly serious in group A than that in group B (P<0.05). Conclusion The level of microleakage of anterior teeth with flared canals, which is restored by fiber post core with the indirect method, is significantly better than that with the direct method. The indirect method has a good edge seal action and is more suitable for clinical application.

Discomfort of right eye and right maxilla region after dental implant placement: a case report / 华西口腔医学杂志

Discomfort of right eye and right maxilla region occurred after a dental implant placement in a patient who surfered stabilized osteofibrous dysplasia (OFD) of sphenoid sinus. In this article, the case was discussed and the relevant literature was reviewed. The possible causes of eye and maxilla discomfort may be associated with OFD, hyper allergic response to implant material and surgical trauma, and psychical factors as well.

Numerical simulation on evolution and control of spiral wave in heart / 生物医学工程学杂志

In this paper, the numerical simulation for evolution and control of spiral waves in 2D cardiac excitable media is performed; it can be represented as modified FitzHugh-Nagumo (FHN) model by selecting suitable parameter values. When the plane wave being cut, the system can evolve into a spiral wave. The excitability of media can produce effect on the stability of spiral wave. When the excitability is greater than the critical value, the spiral wave core and period tend towards infinity and disappear. The drifting ways of spiral wave tip are different (meandering) in various driving frequencies when one spiral wave is driven by uniform periodic small current. When period T is below or above the resonance period of spiral wave, the spiral wave is in its pedaflower or pediflower orbit, and if the driving period precisely equals the resonance period, the spiral wave tip drifts along a straight line.

The heartbeat modes in modified Ikeda phase resetting model / 生物医学工程学杂志

In this paper are proposed four heartbeat models which correspond to two different positions of the ectopic pacemaker and two coupling styles of the sinus and ectopic pacemakers. The models computed are based on the modified Ikeda phase resetting model. Most of the heartbeat modes are periodic; they exhibit "Arnold's tongue" structure in parameter plane of perturbing frequency and strength. When the ectopic pacemaker is located in the ventricle, there are bistable dynamic modes. The abnormal hearbeat rhythms of bigeminy and trigeminy in clinical medicine have been observed when coupling strength is weaker in odd resetting or refractory time is longer in even resetting.

Effects of interleukin-1beta on nitric oxide production and ATP synthesis in rat surplus hepatocytes after partial hepatectomy / 中国医学科学院学报

<p><b>OBJECTIVE</b>To detect the nitric oxide (NO) production and energy metabolism of the interleukin (IL)-1beta-treated residual hepatocytes from rats after partial hepatectomy.</p><p><b>METHODS</b>Forty rats were equally divided into partial hepatectomies (PH) group and control group. In the control group the rats were otherwise matched and underwent sham surgeries. The residual hepatocytes were separated by the collagenase perfusion method. The hepatocytes were cultured with cytokines such as IL-1beta. The production of NO in the two groups were measured with Griess reagent method, the production of inducible nitric oxide synthase (iNOS) protein detected with Western blot, the content of the nucleotide in the hepatocytes detected with high-performance liquid chromatography, and the content of the ketone body in the hepatocytes of the two groups determined with the enzymatic method. Afterwards the ketone body ratio (acetoacetate/beta-hydroxy butyrate, KBR) was calculated.</p><p><b>RESULTS</b>The production of NO in the PH group was twice as much as that in the Sham group. IL-1beta decreased the content of ATP and the KBR in the hepatocytes of both groups, and the decrease magni tude in the PH group was significantly larger than that in the Sham group. After the injection of L-arginine, the production of NO in the hepatocytes in the PH group increased, and the level of ATP and KBR decreased. N(G)-methyl-L-arginine (L-NMMA), the inhibitor of NO synthase, inhibited the production of NO and reversed the decrease of ATP and KBR.</p><p><b>CONCLUSION</b>After partial hepatectomy, increased NO production in the hepatocytes after the treatment of interleukin-1beta may disturb the function of mitochondria by inhibiting the synthesis of ATP.</p>

Effective control of excitable waves in 2D cardiac excitable media / 生物医学工程学杂志

We propose a method for effective control of patter on dissipative system by use of little perturbation analysis, and apply this nonuniform feed back method to control the polarization wave of heart represented by FHN equation. In the numerical experiment, we successfully alter the propagating direction of planar waves and drift the spiral waves to boundary without resonant repulsion. The effective control of the excited system will be used to study the mechanism of defibrillation and that is our interesting work.

The integral term of the information entropy unadapted for being a measuring index / 中国医学物理学杂志

The information entropy, H = - Pk log Pk, has been proved in this paper to be always positive and invariant for a linear coordinate transformation, so that it can be used as a measuring index. On the contrary, the integral term of the information entropy, H(x) = -f(x) log f(x) dx, is not always positive and invariant for a linear coordinate transformation. Therefore, H(x) can not be used as a measuring index. An example of a probability density function for response of nerve to electric current with different intensities is given to confirm above conclusions.