RESUMO
Biochemistry is not only a basic course for biology majors, but also one of the fastest growing frontier courses. Facing the complicated system of biochemistry, the traditional teaching mode exposes many problems, and the teaching effect is not good. With the development of Internet technology, " Internet +" education has developed rapidly. Online courses such as MOOCs and micro-courses provide many colleges and universities with rich learning resources. Online courses such as Dingding Classroom, Tengxun Classroom, Rain Classroom, and WeChat exchange platform also allow students to achieve synchronous learning conveniently. Online teaching has become the main teaching mode of colleges and universities across the country during the COVID-19 epidemic. However, after several years of promotion, pure online teaching has also exposed many problems in terms of teaching effect. In order to give full play to the respective advantages of online and offline teaching, blended teaching has become a new direction. South China Agricultural University began to cooperate with Wisdom Tree Platform in early 2019 to establish the MOOC of biochemistry. During the COVID-19 outbreak in 2020, the online mixed teaching mode of “MOOC + online meet course” is used in teaching. Teaching feedback results showed that "MOOC + online meet course" can be more generally recognized by students than relying solely on MOOC learning. This teaching mode improves students′ learning interest and initiative, improves teaching quality and learning effect, and provides a reference for the application of "MOOC + offline course" in the future.