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1.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 110-113, 2007.
Artigo em Chinês | WPRIM | ID: wpr-269124

RESUMO

<p><b>OBJECTIVE</b>To study the efficacy and safety of Reinhartdt and sea cucumber capsule (RSC) combined with donepezil in treating Alzheimer's disease (AD), and its effect on thyroid function axis.</p><p><b>METHODS</b>Sixty-eight patients were randomly assigned to the RSC group, the Donepezil group and the combined treatment group, who were treated for 3 and 6 months with RSC, Donepezil and RSC combined with Donepezil, respectively. The curative effect was evaluated by scoring according to Mini-Mental State Examination (MMSE), ADAS-Cog and ADL chart, and the level of thyroid hormones, including TSH, FT3, FT4, TT3 and TT4, were measured with radioimmunoassay before treatment, 3 and 6 months after treatment respectively.</p><p><b>RESULTS</b>As compared with the baseline, MMSE score increased, ADAS-Cog score and ADL score decreased significantly in all the three groups after 3 months and 6 months of treatment (P < 0.05 and P < 0.01), but the improvement in the combined treatment group was more significant than that in the other two groups (P < 0.01). After 6 months of treatment, the levels of FT3 and FT4 in the combined treatment group were significantly changed (P < 0.01), but no significant change in all the thyroid hormones was found in the other two groups. No obvious adverse reaction occurred in all the three groups.</p><p><b>CONCLUSION</b>RSC combined with Donepezil in treating AD is effective and safe with no evident adverse reaction, better than single drug treatment, which may be through influencing the metabolism of thyroid hormones to improve the cognition function of AD patients.</p>


Assuntos
Idoso , Idoso de 80 Anos ou mais , Animais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Alzheimer , Tratamento Farmacológico , Cápsulas , Quimioterapia Combinada , Indanos , Usos Terapêuticos , Medicina Tradicional Chinesa , Nootrópicos , Usos Terapêuticos , Piperidinas , Usos Terapêuticos , Radioimunoensaio , Pepinos-do-Mar , Química , Hormônios Tireóideos , Sangue
2.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 887-890, 2007.
Artigo em Chinês | WPRIM | ID: wpr-245616

RESUMO

<p><b>OBJECTIVE</b>To study the efficacy and safety of the combined treatment with compound Reinhartdt and Sea Cumber Capsule (RSC, a Chinese medicinal preparation consisted mainly of Reinhartdt and Sea Cumber) and Donepezil for vascular dementia (VD), and its effect on thyroid function axis.</p><p><b>METHODS</b>Sixty-three patients with VD were treated respectively with RSC, Donepezil and the combined treatment. MMSE, ADAS-Cog and ADL scales were used to evaluate the condition of patients before treatment as well as at 3 months and 6 months after treatment. Meanwhile, levels of thyroid hormones, including (TSH, FT3, FT4, TT3, TT4) were measured with radioimmunoassay.</p><p><b>RESULTS</b>As compared with the baseline, MMSE score increased, ADAS-Cog score and ADL score decreased significantly in all the three groups after 3 months and 6 months of treatment (P <0.05, P<0.01), the improvement in the Donepezil group was more significant than that in the RSC group after 6 months of treatment (P < 0.05), but the combined treatment group showed the best efficacy (P < 0.01). After 3 months of treament, the levels of FT3 and FT4 in the combined treatment group increased, but showed no statistical significance (P >0.05). However, significant changes were found at 6 months after combined treatment (P < 0.01). No significant changes were seen at all in levels of TSH, TT3 and TT4 (P > 0.05). FT3, FT4 increased without statistical significance after 6 months Donepezil treatment, TSH, TT3 and TT4 also showed no significant difference in the Donepezil group and no other significant changes of thyroid hormones was seen in patients treated with RSC (P > 0.05). No obvious adverse reaction occurred in any of the three groups.</p><p><b>CONCLUSION</b>Combined treatment of RSC and Donepezil was effective and safe on VD patient, with the efficacy much better than either of them alone. No significant adverse reaction was observed. The regulation on thyroid hormones may one of the mechanisms of the combined treatment in improving cognitive function.</p>


Assuntos
Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cápsulas , Demência Vascular , Tratamento Farmacológico , Quimioterapia Combinada , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Indanos , Usos Terapêuticos , Materia Medica , Usos Terapêuticos , Medicina Tradicional Chinesa , Nootrópicos , Usos Terapêuticos , Piperidinas , Usos Terapêuticos , Resultado do Tratamento
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