Efficacy analysis of sequential surgery after the DCF scheme induction chemotherapy in T2-3 laryngeal carcinoma and hypopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To study clinical efficacy of surgery after the DCF induction chemotherapy in T2-3 laryngeal carcinoma and hypopharyngeal carcinoma.@*METHOD@#To analyze clinical data about 102 cases of T2-3 laryngeal carcinoma and hypopharyngeal carcinoma retrospectively, 62 cases were divided into experimental group and 40 cases in control group, the experimental group completed three cycles of the DCF induction chemotherapy, then the efficacy was evaluated, surgery were carried out in the end, the control group received operation directly. In two groups, tumor response rates, toxicities, positive surgical margin rates and survival rate differences were observed and compared.@*RESULT@#Tumor response rate was 61.3% in experimental group, the laryngeal carcinoma rate was significantly lower than that in hypopharyngeal (44.4% VS 84.6%, P 0.05). The foci edges of 0. 3 cm and 0. 5 cm positive margin rate of hypopharyngeal carcinoma in experimental group were significantly lower than in its control (P 0.05). During induction chemotherapy in the experimental group, no serious adverse reactions were found.@*CONCLUSION@#Induction chemotherapy of DCF regimen can not only narrow T2-3 laryngeal carcinoma and hypopharyngeal carcinoma' area, but also ensure an adequate safety margin.

The expression and clinical significance of hyaluronan synthase in nasal polyps / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To study the expression of hyaluronan synthasel-3 (HAS1-3) in nasal polyps, and discuss their clinical significance.@*METHOD@#The expression of HA, HAS1, HAS2 and HAS3 in nasal polyps group (25 cases) and inferior turbinate group (15 cases) was detected by immunohistochemistry and semi-quantitative RT-PCR.@*RESULT@#Compared with the control, the expression of HA, HAS1 and HAS3 was higher in nasal polyps (P0. 05).@*CONCLUSION@#The increase of HASI and HAS3 expression may be the main cause of the excessive deposition of HA in nasal polyps, which may play an important role in the pathogenic process of nasal polyps, and become a potential target for therapy of nasal polyps.

Effects of safflower injection on serum superoxide dismntase and malonyldialdehyde with sudden deafness / 实用医学杂志

Objective To explore the treatment mechanism of safflower injection on sudden deafness through the changes of the hearing threshold, serum superoxide dismntase (SOD) and malonyldialdehyde (MDA) before and after treatment. Methods 40 cases of sudden deafness were divided into two groups: groupⅠ(group with safflower) and groupⅡ (group without safflower). The concentrations of serum MDA and SOD and hearing threshold were detected before and after treatment. 25 cases of normal hearing as the control group. Results (1) The total efficiency in the group Ⅰwas higher than the group Ⅱ (P0.05). Conclusion Safflower injection could scavenge oxygen free radical and improve the quality of hearing recovery.