RESUMO
Objective To investigate the effects of dexmedetomidine in combination with sufentanil-based intravenous patient-controlled analgesia. Methods 60 ASA Ⅰ～Ⅱ patients undergoing video-assisted thoracoscopic surgery were divided into two groups (30 patients in each group). In group A, only sufentanil was included in the reagent of patient-controlled analgesia. In group B, dexmedetomidine and sufentanil were included. Results Compared to Group A, consumption of sufentanil in group B at 8h, 24h and 48h after surgery and the incidence of nausea were significantly lower (P＜0.05). The side effects incidences such as vomiting, deep sedation, urine retention and pruritus were comparable between two groups. Conclusion Dexmedetomidine-sufentanil combination for postoperative analgesia in video-assisted thoracoscopic surgery patients resulted in significant sufentanil sparing and lower incidence of nausea.