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Osteoarthritis （OA）， rheumatoid arthritis （RA）， gouty arthritis （GA）， and intervertebral disc degeneration （IVDD） are the most common bone and joint-related diseases in clinical practice. They can all affect related joints， leading to joint pain， swelling， dysfunction， and other symptoms. The difference is that OA is mainly caused by joint wear and age-related degradation and is manifested as joint pain， stiffness， and limited movement. RA is an autoimmune disease， manifested as joint pain， swelling， morning stiffness， and systemic symptoms. GA is caused by abnormal uric acid metabolism， manifested as acute arthritis， and IVDD is caused by intervertebral disc degeneration. Studies have shown that the mechanism of the occurrence and development of these bone and joint diseases is extremely complex. Pyroptosis is closely related to these bone and joint-related diseases by participating in bone and joint inflammation， cartilage metabolism imbalance， extracellular matrix degradation， and pathological damage of bone and joint. Inhibition of bone and joint-related pyroptosis will effectively prevent and treat bone and joint-related diseases. At the same time， many studies have confirmed that traditional Chinese medicine （TCM） has a prominent curative effect and obvious advantages in the prevention and treatment of bone and joint-related diseases. TCM can reduce the inflammatory reaction of bone and joints， improve the pathological damage of bone and joint diseases， and relieve bone and joint pain by inhibiting pyroptosis. Therefore， this article aims to briefly explain the relationship between pyroptosis and the occurrence and development of bone and joint-related diseases and summarize the latest research reports on the intervention of pyroptosis in the treatment of bone and joint-related diseases by TCM monomers， TCM extracts， and TCM compounds. It offers new ideas for the in-depth study of the pathogenesis and drug treatment of bone and joint diseases and provides a basis for the clinical use of TCM to prevent and treat bone and joint diseases.
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Objective:To investigate the effect of total gastric replacement of esophagus and tubular gastric replacement of esophagus on gastroesophageal reflux after esophageal cancer surgery, and the correlation between the anastomosis position and width of tubular stomach and gastroesophageal reflux.Methods:Eighty-eight patients with esophageal cancer admitted to Lu′an Hospital of Peking University Medical Group were retrospectively analyzed. According to the operation methods, they were divided into study group (tube stomach instead of esophagus anastomosis) and control group (whole stomach instead of esophagus anastomosis). The effects of two operation methods on gastroesophageal reflux were compared, and the effects of the position and width of tube stomach instead of esophagus anastomosis on the symptoms were analyzed.Results:Three months after operation, the frequency of acid reflux ≥ 5 minand 24 h acid reflux in the study group were less than those in the control group: (2.5 ± 1.7) times vs. (6.2 ± 2.1) times, (17.3 ± 8.8) times vs. (31.5 ± 7.9) times; the total time of pH < 4 and the longest acid reflux time in the study group were shorter than those in the control group: (85.3 ± 30.1) min vs. (118.2 ± 32.6) min, (22.4 ± 6.8) min vs. (31.8 ± 7.4) min; and the differences were statistically significant ( P<0.05). The reflux disease questionnaire score and the incidence of gastroesophageal reflux disease in the study group were lower than those in the control group: (8.9 ± 4.6) scores vs. (13.8 ± 4.1) scores, 6.7%(3/45) vs. 23.3%(10/43), and the differences were statistically significant ( P<0.05). In the 4 subgroup of the study group, the incidence of reflux symptoms, pH<4 cumulative time and the number of reflux symptoms were the lowest in the cervical anastomosis+width<3 cm subgroup, and the histological inflammatory reaction grade of esophageal mucosa under endoscopy was the lightest in the study group, and the differences were statistically significant ( P<0.05). Conclusions:Compared with total gastric anastomosis, tube stomach instead of esophagus anastomosis can reduce the incidence of gastroesophageal reflux more effectively, and neck anastomosis+tube stomach width <3 cm and anastomosis method are the best for gastroesophageal reflux.
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Objective To observe long-term clinical and rehabilitation effect of Xingnaojing injection with hyperbaric oxygen on the stroke patients with hemiplegia.Methods100 patients with cerebral apoplexy hemiplegia from May 2012 to April 2014 in Wuzhong City People's Hospital Affiliated to Ningxia Medical University during the period.According to the stochastic indicator method, the object of this study were divided into experimental group (50 cases) and control group (50 cases).For all patients with conventional treatment, daily aspirin 0.5 g, nim horizon each time, three times a day oral treatment, control group patients on the basis of the joint 20 mL Xingnaojing injection, once a day.Patients in the experimental group were given hyperbaric oxygen treatment on the basis of the combination, for an hour every day.Treatment for 2 months after hospital discharge, 18 months after treatment to return of two groups of patients, compared two groups of patients before and after treatment action, ability of daily life, the quality of life as well as the secondary injury, and the patient's neurologic deficits were evaluated.ResultsIn 18 months after treatment, the treatment group patients walk rate was 68%, significantly higher than that of control group 42%(P<0.05), nerve function defect assessment in experimental group patients was (10.43±2.19) scores,was significantly better than control group (16.04±3.23) scores, daily life ability, life quality and improve secondary injury effect in experimental group was significantly better than control group, difference has statistical significance (P<0.05).ConclusionXingnaojing injection combined hyperbaric oxygen treatment of stroke patients with hemiplegia, can improve long-termdaily life skills, and improve quality of life with rehabilitation, the long-term clinical effect is remarkable, less adverse reaction.
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Objective To investigate the effect of ganglioside on nerve function in patients with hypertensive cerebral hemorrhage after operation. Methods 90 cases with hypertensive cerebral hemorrhage after operation from March 2014 to March 2016 in our hospital were divided into control group and observation group, the control group was treated with routine treatment, the observation group was given ganglioside nerve cell nutrition therapy, the two groups of patients after treatment of clinical efficacy, neurological function score, ADL score, hematoma, edema were observed.Result The total effective rate(91.11%) in the observation group was significantly higher than that in the control group(66.67%)(P <0.05), the difference was statistically significant.After 7 days and 28 days after treatment, the volume of hematoma and edema in the observation group was significantly decreased, and the control group had obvious advantages compared with the control group ( P <0.05 ).Compared with seventh days and twenty-eighth days after treatment, the NIHSS score and ADL score of the observation group were significantly better than the control group ( P <0.05 ) , the difference was statistically significant.Conclusion The application of the ganglioside in the treatment of hypertensive cerebral hemorrhage can significantly improve the neurological function, improve the quality of life of patients and clinical treatment effect, has good clinical application value.