Screening for precursors of colorectal cancer / 中华流行病学杂志

Screening has been proven to be effective for the control of colorectal cancer (CRC).The target of CRC screening is shifting from CRC to colorectal neoplasia (CN),the precursors of CRC.Based on the the latest national guideline,the Consensus of Screening for CRC and CN,and the recent research of precursors both at home and abroad.This paper summarizes the progress in the research of risk factors,risk prediction model,screening strategy optimization,colonoscopy quality control,sessile serrated adenoma identification and follow up as well as the recognition of precursors.

Screening for precursors of colorectal cancer / 中华流行病学杂志

Screening has been proven to be effective for the control of colorectal cancer (CRC).The target of CRC screening is shifting from CRC to colorectal neoplasia (CN),the precursors of CRC.Based on the the latest national guideline,the Consensus of Screening for CRC and CN,and the recent research of precursors both at home and abroad.This paper summarizes the progress in the research of risk factors,risk prediction model,screening strategy optimization,colonoscopy quality control,sessile serrated adenoma identification and follow up as well as the recognition of precursors.

Development of Targets for Anti-influenza Virus Based on Nucleoprotein / 病毒学报

The influenza A is an acute respiratory infection persistently threatening human health and social stability, and has caused high morbidity and mortality. The development of novel anti-influenza drugs based on new targets is very significant because of high mutation and drug resistance of influenza virus. The nucleoprotein of influenza A virus identified high conservation, provides cross immune protection as a potential target of anti-influenza drugs and reports on relevant studies have been published at home and a- board. Herbal drug as a traditional Chinese medicine shows the distinct advantages in the aspect of prevention and treatment of influenza A. This paper analyzes the structure and function of influenza a virus, and reviews the advances in the research on anti-influenza targets based on the nucleoprotein of the influenza A virus.

PROTEIN REQUIREMENTS OF CHINESE MALE ADULTS / 营养学报

The subjects were all Chinese male adults. The average age, body weight and height were 37.9 (24-44) yr, 64.3 (51.5-74.0) kg and 173 (157-180) cm respectively in the first group, and 30.2 (24-41) yr, 67.7 (56.5-70.0) kg and 171 (170-176) cm respectively in the second group.The subjects in the first group were studied for 70 days for the N balance response at graded protein intakes of 0.42, 0.60, 0.73, 0.90 and 1.05 g/kg /day on Chinese mixed diet, during 5 experimental periods respectively. Each period took ten days preceded by one day of low protein diet, and was followed by three days of free choice diet The sequence of protein intakes during the study was 0.60, 0.73, 0.42, 0.90 and 1.05 g/kg/day. Six subjects in the second group were given a mixed diet ata protein level of 0.93 (0.91-0.94) g/kg/day for three months.In the N balance data of the first group, all subjects were in negative balance at protein intake of 0.42, 0.60 and 0.73 g/kg/day and all in positive N balance at 1.05 g/kg/day. Most of the subjects were in positive N balance at 0.90 g/kg/day. The linear regression analysis of N balance response of individual subject is that the intercept at zero balance of individuals ranged from 129.4-192.5 mg N/kg/day with the mean of the group of 147.7? 18.6mg N/kg/day or 0.92?0.12 g protein/kg/day. The five of the six subjects in the second group were in positive N balance, when on a mixed diet of 0.93 ?0.02 g protein/kg/day for three months.The results obtained indicated the mean protein requirement of these subjects based on the linear regression analysis of N balance response of individuals was 147.7 ? 18.6 mg N/kg/day or 0.92?0.12 g protein/kg/day. If 97.5% is to be covered, the safe level of protein intake should be 1.16 g protein/ kg/day.