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Journal of Central South University(Medical Sciences) ; (12): 382-387, 2009.
Artigo em Inglês | WPRIM | ID: wpr-814317

RESUMO

OBJECTIVE@#To investigate a new way to yield plenty of high purity olfactory ensheathing cells (OECs) and its biocompatibility with appropriate scaffolds.@*METHODS@#OECs were prepared from neonatal Wister rats and co-cultured with poly [LA-co-(Glc-alt-Lys)] (PLGL). Its contact angle, adherent rate, and activity rate were tested.@*RESULTS@#The contact angle of poly (D, L-lactic acid) (PDLLA) (84.5 degree+/-1.5 degree) was significantly higher than that of PLGL (52.6 degree+/-0.8 degree), the adherent rate of PLGL (80%) was significantly higher than that of the PDLLA (57%), and the activity rate of PLGL (88%) was much higher than that of the PDLLA (76%).@*CONCLUSION@#PLGL possesses better hydrophilicity and biocompatibility than PDLLA, and it can provide a better cell growth circumstance which is helpful for the effective treatment of nerve injury.


Assuntos
Animais , Ratos , Animais Recém-Nascidos , Materiais Biocompatíveis , Células Cultivadas , Ácido Láctico , Farmacologia , Regeneração Nervosa , Bulbo Olfatório , Biologia Celular , Ácido Poliglicólico , Farmacologia , Copolímero de Ácido Poliláctico e Ácido Poliglicólico , Ratos Wistar , Traumatismos da Medula Espinal , Engenharia Tecidual , Métodos , Alicerces Teciduais , Química
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