RESUMO
Objective To compare the treatment effect of different dose of omeprazole in the treatment of chronic gastric ulcer.Methods 153 patients with gastric ulcer were selected as the research object,according to ran-dom number table.The patients were randomly divided into three groups,with each group of 51 cases.In the first three days,group A was given omeprazole 40mg added to 0.9% sodium chloride injection 20mL,intravenous drip,4 times/d. Group B was given omeprazole 40mg added to 0.9% sodium chloride injection 100mL,intravenous drip 2 times/d. Group C was given omeprazole 40mg added to 0.9% sodium chloride injection 100mL,intravenous drip 1 time /d. Then took omeprazole magnesium enteric -coated tablets oral,20mg/times,1 time /d.The treatment course was 4 weeks.The treatment effectiveness and adverse reactions were observed.Results The effective rates of 3 groups had significant difference(χ2 =11.573,P =0.003).The effective rate of group A was 98.3%,which was significantly higher than 84.3% of group B(χ2 =6.725,P =0.010)and 74.5% of group C(χ2 =11.922,P =0.001).The effec-tive rate of group B was higher than that of group C,but the difference was no statistically significant(χ2 =1.499,P =0.221).The patients of 3 groups had occasional headache,nausea,vomiting,fatigue,skin rashes and other adverse reactions,the symptom was lighter,there was no impact to the normal treatment.Conclusion In the first three days of the treatment,omeprazole added to 0.9% sodium chloride injection 20mL,intravenous drip,4 times/d,then taking omeprazole magnesium enteric -coated tablets oral to treat gastric ulcer has higher curative rate,less adverse reac-tion,the effect is better than that of middle and low doses of the drug,which has clinical value.
RESUMO
Objective To study changes and meaning of serum IL -4,IL -10,IFN -gamma,TGF -beta 1 level in patients with delayed encephalopathy after carbon monoxide poisoning.Methods From January 2011 and June 2014 in our hospital,40 cases of DEACMP patients were selected as group A;the 40 patients with DEACMP was divided into 12 cases of mild cognitive dysfunction,mild cognitive dysfunction in 20 cases,8 cases of severe cognitive dysfunction.40 cases with acute carbon monoxide poisoning (ACMP)patients were selected as group B;40 cases of healthy subjects were selected as healthy controls.Serum interleukin 4 and interleukin 10(IL -4)(IL -10),interfer-on gamma (IFN -gamma),conversion,growth factor beta 1 (TGF -beta 1)content were tested.Results In Group A and group B serum IL -4 levels were lower than that of healthy controls (P <0.01),and serum levels of IL -10 in group B were higher than that in group A and healthy controls (P <0.01),serum level of IFN -gamma in group A and group B was higher than the healthy controls (P <0.01),and in group A IFN -gamma levels were higher than group B (P <0.01),while in group A serum TGF -beta 1 level was lower than B group and the control group (P <0.01),and in group B TGF -beta 1 level was higher than the control group (P <0.01);With cognitive impairment aggravating of DEACMP patients,IL -4,IL -10,TGF -beta 1 levels were on the decline,and IFN -gamma level was increasing (P <0.01).Conclusion DEACMP patients serum and cerebrospinal fluid of IL -4,IL -10,IFN -gam-ma,TGF -beta measures such as abnormal expression,showed that the onset of DEACMP may be related to neural immune injury.Serum IL -4,IL -10,IFN -gamma and TGF -beta of DEACMP patients exists abnormal expression Serum IL -4,IL -10,IFN -gamma and TGF -beta levels are also related to the degree of cognitive impairment of DEACMP patients.The onset and progress of DEACMP may be associated with neural immune injury.