Effect of Shugan Jieyu capsule on depression in patients with schizophrenia / 中国基层医药

Objective@#To investigate the effect of Shugan Jiayu capsule on depression in patients with schizophrenia.@*Methods@#From January 28, 2016 to January 24, 2017, 82 schizophrenic patients in Wenling Psychiatric Rehabilitation Hospital were selected in the study.All the patients had depressive symptoms and were divided into two groups by random number table method, with 41 cases in each group.Both two groups were treated with routine therapy.The control group was treated with quetiapine, and the observation group was given Shugan Jieyu capsule.The improvement of the disease and the occurrence of adverse events in the two groups were observed.@*Results@#At two weeks and one month after treatment, the Hamilton Depression Scale(HAMD) scores of the observation group[(16.97±2.23)points and (12.53±1.88)points] were lower than those of the control group (t=3.06, 5.52, all P<0.05). After one week, two weeks and one month of treatment, the Brief Psychiatric Rating Scale(BPRS) scores of the observation group[(30.29±2.41)points, (25.47±2.59) and (21.03±2.77)points] were lower than those of the control group (t=6.17, 6.60, 10.20, all P<0.05). After one week, two weeks and one month of treatment, the Positive and Negative Symptom Scale(PANSS) scores of the observation group were (72.76±3.83)points, (41.50±3.46)points and (33.94±2.89)points, respectively, which were better than those of the control group(t=4.02, 12.25, 13.40, all P<0.05). The incidence rate of adverse events in the observation group[4.88%(2/41)] was obviously lower than that in the control group[19.51%(8/41)](χ2=4.10, P<0.05). The recurrence rates of the observation group after 3 months and 6 months were 7.32%(3/41) and 12.20%(5/41), respectively, which were lower than those of the control group[26.83%(11/41) and 34.15%(14/41)](χ2=5.51, 5.55, P<0.05).@*Conclusion@#Shugan Jieyu capsule can effectively improve the depressive symptoms of schizophrenia patients.

Effect of Shugan Jieyu capsule on depression in patients with schizophrenia / 中国基层医药

Objective To investigate the effect of Shugan Jiayu capsule on depression in patients with schizophrenia.Methods From January 28,2016 to January 24,2017,82 schizophrenic patients in Wenling Psychiatric Rehabilitation Hospital were selected in the study.All the patients had depressive symptoms and were divided into two groups by random number table method,with 41 cases in each group.Both two groups were treated with routine therapy.The control group was treated with quetiapine,and the observation group was given Shugan Jieyu capsule.The improvement of the disease and the occurrence of adverse events in the two groups were observed.Results At two weeks and one month after treatment,the Hamilton Depression Scale (HAMD) scores of the observation group [(16.97 ± 2.23) points and (12.53 ± 1.88) points] were lower than those of the control group (t =3.06,5.52,all P ＜ 0.05).After one week,two weeks and one month of treatment,the Brief Psychiatric Rating Scale (BPRS) scores of the observation group[(30.29 ±2.41)points,(25.47 ±2.59) and (21.03 ±2.77)points] were lower than those of the control group (t =6.17,6.60,10.20,all P ＜ 0.05).After one week,two weeks and one month of treatment,the Positive and Negative Symptom Scale(PANSS) scores of the observation group were (72.76 ± 3.83)points,(41.50 ±3.46) points and (33.94 ± 2.89) points,respectively,which were better than those of the control group (t =4.02,12.25,13.40,all P ＜ 0.05).The incidence rate of adverse events in the observation group [4.88％ (2/41)] was obviously lower than that in the control group[19.51％ (8/41)] (x2 =4.10,P ＜ 0.05).The recurrence rates of the observation group after 3 months and 6 months were 7.32％ (3/41) and 12.20％ (5/41),respectively,which were lower than those of the control group[26.83％ (11/41) and 34.15％ (14/41)] (x2 =5.51,5.55,P＜0.05).Conclusion Shugan Jieyu capsule can effectively improve the depressive symptoms of schizophrenia patients.

The analysis of pathogenic bacteria for inpatients with systemic lupus erythematosus or lupus nephritis / 重庆医学

Objective To retrospectively analyse pathogenic bacteria isolated from inpatients with lupus erythematosus (SLE) and lupus nephritis (SLE‐LN ) ,and provide references for diagnosis and treatment for these patients with infection . Methods A total of 380 inpatients diagnosed with SLE/SLE‐LN in our hospital from 2010 to 2014 were enrolled in this study ,in‐cluding 96 cases of patients with SLE‐LN .Bacterial inoculation ,culture ,isolation ,identification and drug sensitivity test were carried out .Statistical analysis and susceptibility analysis was performed by using the SPSS 19 .0 and WHONET5 .6 software .Results For patients with SLE and SLE‐LN ,urinary tract infection accounted for 25 .0% and 27 .1% ,hematogenous infection accounted for 8 .1% and 10 .4% ,skin tissue infection accounted for 12 .0% and 8 .3% ,respectively .The most common gram negative bacteria was Escherichia coli ,which accounted for 25 .53% and 30 .21% in patients with SLE and patients with SLE‐LN ,respectively .Followed by Bauman Acinetobacter ,which accounted for 13 .42% and 14 .54% in patients with SLE and patients with SLE‐LN ,respectively . The most common gram positive bacteria was Staphylococcus aureus ,which accounted for 11 .58% and 11 .46% in patients with SLE and patients with SLE‐LN ,respectively .Strains of Escherichia coli were isolated from urine specimens of 69 .79% of patients with SLE and 66 .67% patients with SLE‐LN ,the percentages were significantly higher than that of the conventional urine culture (45% ,P< 0 .01) .The resistance rate of Escherichia coli strains isolated from patients with SLE to quinolones was higher than 66 .00% ,the resistance rate to ampicillin was 89 .69% ,and the resistance rate to piperacillin/tazobactam was low (3 .09% ) .The iso‐lation rates of ESBLs‐producing Escherichia coli strains and ESBLs‐producing Klebsiella pneumoniae strains in patients with SLE‐LN were higher than those in patients with SLE .Conclusion The patients with SLE have a higher risk for infection .The beta‐lac‐tams could be used for the treatment of Escherichia coli urinary tract infection in patients with SLE .

Risk factors of bloodstream infections caused by vancomycin-resistant Enterococcus / 中国感染与化疗杂志

Objective To analyze the bloodstream infections caused by vancomycin‐resistant Enterococcus (VRE)in West China Hospital and examine the risk factors of such infections for best control of VRE infections .Methods Case‐control method was used to compare the bloodstream infections due to VRE with those caused by vancomycin‐susceptible Enterococcus(VSE)from August 2010 to August 2014 in West China Hospital .The data were compared by T‐test ,Chi‐square test (univariate analysis) and logistic regression analysis (multivariate analysis) using SPSS 19 .0 software .Results A total of 31 VRE strains were isolated from bloodstream infections in the study period ,including 5 (16 .1 % ) strains of vancomycin‐resistant Enterococcus faecalis and 26 (83 .9 % )strains of vancomycin‐resistant Enterococcus faecium .In the past four years ,the prevalence of vancomycin‐resistant E . f aecalis in bloodstream infections was 1 .5% ,1 .6% ,1 .8% ,and 1 .2% ;while the prevalence of vancomycin‐resistant E . f aecium in bloodstream infections was 3 .8% ,4 .4% ,5 .8% ,and 7 .1% .Such VRE bloodstream infection was mainly found in Intensive Care Unit (ICU)(13 ,41 .9% )and Department of Neurosurgery (4 ,12 .9% ) .More than 90% of the isolates were resistant to ampicillin and erythromycin .But less than 20% of the strains were resistant to quinupristin‐dalfopristin and linezolid . Univariate analysis indicated that prolonged hospital stay , ICU admission , venous catheter ,prior carbapenem exposure , prior vancomycin/norvancomycin exposure were associated with VRE bloodstream infections .Logistic regression analysis confirmed that venous catheter was an independent risk factor of VRE bloodstream infections .Conclusions Venous catheter is an independent risk factor for VRE bloodstream infections . Infection control measures should be strengthened to prevent the outbreak of VRE‐related bloodstream infections .

Analysis of smile line of Zhuang-Chinese youths / 实用口腔医学杂志

Objective:To analyze and the smile line of Zhuang-Chinese youths.Methods:1 00 Zhuang volunteers aged 1 8-25 years were recruited for this study.The faces were individually registered by digital videography.The length and thickness of upper lips and mandibular incisor crown height appearance at rest,smile and laugh were recorded.Statistical analysis was performed using Mann-Whitney-U Test and non-parametric analysis.Results:The upper lip in men was longer than that in women at rest(P<0.05 ).The upper lip length increased and thickness decreased at smile and laugh in all subjects,in men was longer and thicker than in women(P<0.05),but there was no significant difference of upper lip thickness at rest between sexes(P<0.05).The mandibular anterior teeth,gingival papilla of all subjects were appeared at smile and laugh,there was no significant difference between sexes(P<0.05). Gingiva appearance at smile was in less than 1 0%of the subjects.39%subjects had high smile line,46%had average smile line and 1 5% had low smile line.Conclusion:Most of the Zhuang youths have moderate smile line,less high smile line and least low smile line.

Analysis of the carbapenemase-producing mechanism of Enterobacteriaceae with decreased susceptibility to carbapenems / 南方医科大学学报

<p><b>OBJECTIVE</b>To analyze the distribution of Enterobacteriaceae isolated from West China Hospital, investigate the antibiotic resistance profile of Enterobacteriaceae with decreased susceptibility to carbapenems and explore the molecular mechanism.</p><p><b>METHODS</b>Forty-five Enterobacteriaceae strains resistant or with reduced susceptibility to carbapenems were isolated from patients in West China Hospital. The antimicrobial susceptibility and carbapenemase-producing phenotypes of the bacteria were examined and specific PCR were performed to determine the molecular mechanism.</p><p><b>RESULTS</b>Of the 45 isolates, 17, 21 and 36 were resistant or intermediate strains to imipenem, meropenem and ertapenem, respectively. The majority of these isolates showed resistance to cephalosporins. The modified Hodge test resulted in the highest positivity rate (77.8%), followed by EDTA disc test (57.8%) and PBA disc test (22.2%). BlaTEM, blaSHV and blaCTX-M were detected in 60.0%, 53.3% and 15.6% of these strains with reduced susceptibility. The rate of strains carrying 2 or more genes was 44.4%, and the detection rate of blaIMP was 48.9%. BlaKPC was identified in 4 (8.9%) high-level resistant strains and confirmed to locate on the plasmid.</p><p><b>CONCLUSION</b>Production of carbapenemase contributes to reduced susceptibility of carbapenems in Enterobacteriaceae. The presence of blaKPC, MBL and ESBL, and their possible combinations can be the main factor contributing to carbapenem resistance or reduced susceptibility in Enterobacteriaceae. The KPC-2 carbapenemase gene located on the plasmids we found in this study can cause potential horizontal transmission across strains.</p>

Nosocomial Meticillin-resistant Staphylococcus aureus in Huaxi Hospital for Five Years / 中华医院感染学杂志

OBJECTIVE To investigate the clinical characteristics and drug resistance of meticillin-resistant Staphylococcus aureus(MRSA) among inpatients in Huaxi Hospital in five years.METHODS We analyzed clinical distribution and resistant data on inpatients infected with MRSA between Jan 2003 and Dec 2007 in Huaxi Hospital,and collected the annual consumption of common used antibiotics,amount of MRSA isolates and MRSA isolated rate from Staphylococcus aureus(SA) strains.The data were analyzed by the method of Spearman analysis in SPSS.RESULTS We analyzed totally 1478 MRSA strains.The most common specimens of MRSA were sputum(70.8%),other secretions(14.2%) and blood(4.6%).The MRSA strains were frequently detected in ICU(29.8%),Department of surgery(17.3%) and Department of respiratory Medicine(6.4%).The drug resistance rate to ampicillin,tetracycline,rifampin,imipenem,ciprofloxacin,gentamicin,cefalothin,cefotaxime and cefazolin were beyond 90% in five years.The drug resistance rate against Erythromycin,Clindamycin and Clarithromycin decreased gradually from 93.1%,92.2% and 95.5% in 2003 to 82.3%,76.7% and 81% in 2007.It had not been found the vancomycin-resistant MRSA.Except Cotrimoxazole,the drug resistance rates of MRSA in ICU were almost higher than those in non-ICU departments.Based on the SPSS analysis,we concludea that annual consumption of etimicin had a positive correlation with MRSA,and

Analysis of the responsiveness of patients in Shanghai / 中华医院管理杂志

A typical investigation on third-tier general hospitals, third-tier specialty hospitals, second-tier district or county central hospitals, urban community hospitals, and rural township health centers in Shanghai was conducted so as to examine the responsiveness of outpatients and inpatients to the health system. Most of the patients surveyed said that they could get prompt attention and that they had convenient access to medical information from the community or the mass media. More than half of the inpatients and outpatients thought that they had autonomy with regard to treatment and a greater number of patients made their own choices of doctors and nurses. Most of the patients were willing to talk freely with their doctors about their confidential medical history and could get rational explanations about their conditions from the doctors. The results indicate that reform of the health system in Shanghai has attached importance to the responsiveness of patients and that good effects have been achieved.

A study of the points for attack on the problem of hospital control of medical cost and the intensity of the attack / 中华医院管理杂志

A summary is made on a11 the experiences from five attached general hospitals which carried out Shanghai new policy of Work rescheduling and organization restracturing.The external pressure and internal motive of the change from"compulsory rescheduling"to"voluntary rescheduling" are analyzed.A search for the distribution of the points for attack on the problem of hospital control of medical cost is made.A comparative study is conducted on the relationship between time and the inten- sity of the control,the inner relationship between the independent variables and the intensity of control. The conclusion shows the change of the hospital's control role to the voluntary one has something to do with the equalibrium of relative forces.The point for breakthrough lies at the control of drugs.A search for the points for attack on the problem of hospital control of medical cost is not only necessary for arresting the rocketing of medical cost,but also helpful for capturing the confidence of the concerned and strengthening hospital management,thus laying a good foundation for a stable transition to a new healthcare insurance program.