Reconsideration on the network behavior and health / 中华行为医学与脑科学杂志

With the rapid development of network technology and the situation of COVID-19 pandemic, the way people use the Internet has changed dramatically, causing the original network behavior to change again and again, and with its huge impact on people's mental and physical health.This paper deeply elaborate the connotation and development of network behavior and analyzes the impact of network behavior on people's health under COVID-19, then puts forward suggestions to speed up the construction of information infrastructure, strengthen network legislation, improve the information literacy of the whole population, and purify the network environment.

circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis / 中华医学杂志(英文版)

BACKGROUND@#Circular RNAs (circRNAs) are considered to be important regulators in cancer biology. In this study, we focused on the effect of circRNA baculoviral inhibitor of apoptosis protein (IAP) repeat containing 6 (circBIRC6) on non-small cell lung cancer (NSCLC) progression.@*METHODS@#The NSCLC and adjacent non-tumor tissues were collected at Shanghai Ninth People's Hospital. Quantitative real-time polymerase chain reaction was conducted for assessing the levels of circBIRC6, amyloid beta precursor protein binding protein 2 (APPBP2) messenger RNA (mRNA), baculoviral IAP repeat containing 6 mRNA (BIRC6), and microRNA-217 (miR-217). Western blot assay was adopted for measuring the protein levels of APPBP2, E-cadherin, N-cadherin, and vimentin. Colony formation assay, transwell assay, and flow cytometry analysis were utilized for evaluating cell colony formation, metastasis, and apoptosis. Dualluciferase reporter assay and RNA immunoprecipitation assay were carried out to determine the interaction between miR-217 and circBIRC6 and APPBP2 in NSCLC tissues. The murine xenograft model assay was used to investigate the function of circBIRC6 in tumor formation in vivo. Differences were analyzed via Student's t test or one-way analysis of variance. Pearson's correlation coefficient analysis was used to analyze linear correlation.@*RESULTS@#CircBIRC6 was overexpressed in NSCLC tissues and cells. Knockdown of circBIRC6 repressed the colony formation and metastasis and facilitated apoptosis of NSCLC cells in vitro and restrained tumorigenesis in vivo. Mechanically, circBIRC6 functioned as miR-217 sponge to promote APPBP2 expression in NSCLC cells. MiR-217 inhibition rescued circBIRC6 knockdown-mediated effects on NSCLC cell colony formation, metastasis, and apoptosis. Overexpression of miR-217 inhibited the malignant phenotypes of NSCLC cells, while the effects were abrogated by elevating APPBP2.@*CONCLUSIONS@#CircBIRC6 aggravated NSCLC cell progression by elevating APPBP2 via sponging miR-217, which might provide a fresh perspective on NSCLC therapy.

Reconsideration on the multiple values of behavior determining health: in the perspective of the situation of COVID-19 / 中华行为医学与脑科学杂志

Why has the concept of behavior determining health created more and more extensive and far-reaching influences ever since it was put forward? The reason lies in its multiple values.It is of great practical significance and has important implications for both the long-term health care and the current situation of COVID-19 to explore and analyze its philosophical values, cultural values, methodological values, social values and the national strategic value of " Healthy China" .

Reconsideration on the multiple value of Behavior determining Health: in the perspective of the situation of COVID-19 / 中华行为医学与脑科学杂志

Why has the concept of behavior determining health created more and more extensive and far-reaching influence ever since it was put forward? The reason lies in its multiple values. It is of great practical significance and has important implications for long-term health care to explore and analyze in the perspective of the situation of COVID-19 its philosophical values, cultural values, methodological values, social values and the national strategic value of "healthy China".

Chronic brain disease and cognitive impairment:research progress and expert argument / 中华行为医学与脑科学杂志

Cerebrovascular disease,Alzheimer's disease,Parkinson's disease and other chronic encephalopathy has become a worldwide public health problem.Cognitive impairment,including mild cognitive impairment to dementia,is closely related to chronic encephalopathy,especially cerebrovascular diseases.Early detection,early diagnosis,early treatment of cognitive impairment has become the focus of the research,in order to reduce the development of dementia,improve the quality of life and reduce the burden of disease.This article elaborates the research progress of cognitive impairment from the aspects of pathological mechanisms,risk factors,clinical diagnosis and strategy prevention and control,and the arguments of domestic experts.

Comments on behaviors determining health / 中华行为医学与脑科学杂志

The health is the precious societal treasure and the essential elements for human.The pursuit of health is the eternal theme for human.With the development of society,more than 60％ of chronic non-communicable diseases are caused by unhealthy behaviors and lifestyles,so that these unhealthy behaviors and lifestyles have become the greatest killer for the human health and brought huge disease burden for family and society.Therefore,advocating the good behaviors and lifestyles and modifying bad behaviors and lifestyles have become the fundamental method to keep in good health and to promote social development.The view that behaviors determine health not only covers psychological balance,adherence to healthy diets,increase in physical exercise and control of tobacco and alcohol use which intervene human health in basic necessities of life,but also includes morality promotion.Moral health is the foundation of psychological health and physical health.The social culture of behaviors determining health will be widely popular and the psychological and physical health will finally come true,only when adhering to healthy behaviors and lifestyles in all aspects of human' s daily life over the lifespan.

The relationship between aggressive behaviors and clinical features in the inpatients with schizophrenia / 中华行为医学与脑科学杂志

Objective To explore the relative factors of aggressive behaviors in inpatients with schizophrenic.Methods 178 cases of continuously admitted schizophrenic patients were divided into attack group and non aggressive group according to the aggressive behavior of preadmission.Single factor analysis and multi factor regression analysis was applied to two groups in situation(such as age,gender,education level,course of disease,past aggressive behaviors and so on),Brief Psychiatric Rating Scale (BPRS) and Eysenck Personality Questionnaire (EPQ).Results By single factor analysis,attack group had significantly longer course of disease(7.73±6.67) than non aggressive group (5.22 ± 5.47,t =2.631,P＜ 0.01).The score of hostile suspicious factor in BPRS (13.73 ± 3.098) in attack group was significantly higher than that in nonaggressive group(11.47±3.93) (t=4.063,P＜ 0.01),but anxiety factor (7.18± 3.583) was significantly lower than that in nonaggressive group (8.70 ± 3.89) (t=2.679,P＜0.01).The score of E scale of EPQ(11.99±4.340) in attack group was significantly higher than that in nonaggressive group(10.67±4.293) (t=1.990,P＜0.01).Attack group's proportion of patients of previous attacks (71.1％) was significantly higher than that in non aggressive group (16.0％),(x2 =39.082,P＜ 0.01).(2) Logistic analysis showed that hostile suspicious factor in BPRS and past aggressive behaviors entered the regression equation.Condusions Aggressive behavior in schizophrenic patients occurs mainly with psychiatric symptoms and the past history of aggressive behavior.The patients should be treated actively to control the symptoms and prevent the disease recurrence.

Associations between brain-derived neurotrophic factor gene polymorphisms and cognitive disorder in depression / 中华行为医学与脑科学杂志

Objective To explore the relationship between polymorphisms of brain-derived neurotrophic factor(BDNF) gene (rs6265 and rs12273539) and cognitive impairment in depressive disorder.Methods All participants including 73 depressed patients and 71 healthy controls were received clinical and cognitive assessments at admission,and then the depression group was divided into two groups by the score of Beijing version of the Montreal Cognitive Assessment (MoCA-BJ).One was depression with cognitive dysfunction group,and the other was depression without cognitive dysfunction group,with 36 and 37 cases respectively.The polymorphisms of BDNF gene was identified by PCR-RFLP.Results No significant difference for rs6265 gene types(x2=5.18,P=0.27),A allele carries (x2 =4.28,P=0.12) and G allele carries (x2 =1.95,P=0.38) among the three groups.There was no significant difference for rs12273539 gene types,allele carries between patients without cognitive dysfunction and controls groups(P＞0.05).There was much more C-allele carries (x2=5.40,P=0.02)and less T-allele(x2=6.06,P=0.01) in patients with cognitive disorder than those in health and it was different in rs12273539 gene types between the two groups(x2=8.38,P=0.02).CC/CT/CT gene type performed different on attention function (P＜0.01).Conclusion BDNF rsl2273539(T/C) gene type has relationship with the onset of cognitive disorder in depressed patients,and there are more C-allele carries in depressive patients.The depression patients with CC gene type are worse on the attention function impairement.

The correlation of cognitive dysfunction with serum brain-derived neurotrophic factor level in depression patients / 中华行为医学与脑科学杂志

Objective To investigate the characteristics of cognitive dysfunction in patients with depression,and identify the correlation between cognitive dysfunction and serum brain-derived neurotrophic factor (BDNF) level.Methods All participants including 73 depressed patients and 71 healthy controls were received clinical and cognitive assessments at admission,the depression group was divided into two groups by the score of Beijing version of the Montreal Cognitive Assessment (MoCA-BJ),one was depression with cognitive dysfunction group which had 36 cases,the other was depression without cognitive dysfunction group which had 37 cases.Concentration of BDNF was measured by the ELISA method.Results Cognitive impairments were found in numerous cognitive domains of depressed patients,including visuospatial and executive abilities,attention,delayed recall and orientation(P ＜ 0.05).The incidence of cognitive dysfunction in depression was 49.3％.There was not significant difference between two depressive groups (depression with cognitive disorder(12.08 ± 7.08)ng/ml,depression without cognitive disorder (12.22 ± 7.93)ng/ml,P ＞ 0.05),and the levels were significantly lower than that in healthy people ((16.55 ± 7.47) ng/ml,P＜ 0.01),and serum BDNF level had no positively relevant with different cognitive functions (P ＞ 0.05).Conclusion Depression patients have cognitive dysfunction in numerous cognitive domains,including visuospatial and executive abilities,attention,delayed recall and orientation.Serum BDNF level is closely related with depression,while,it has no obvious relationship with cognition function in depression.

The clinical efficacy of psychological intervention on coronary heart disease paitents with anxiety after percutaneous coronary intervention / 中华行为医学与脑科学杂志

Objective To study psychological change on anxiety patients with coronary heart disease (CHD) after percutaneous coronary intervention and to explore the effect of psychological intervention on anxiety patients with CHD.Methods The selected 126 anxiety patients with CHD were randomly divided into three groups A,B,C,and 42 cases in each group.Group A of was the control group,group B was the anti-anxiety drug group,group C was the psychological intervention combinded with anti-anxiety drug,and all patients were treated for one month.The self-rating anxiety scale (SAS) scores were recorded in three groups before surgery,after one week and one month treatment.Resluts There was no significant difference in SAS scores in group A before the operation and after 1 week,1 month treatment(respectively(57.14 ±5.63),(55.86 ±5,46),(53.93 ±6.03),P＞ 0.05).After 1 week and 1 month treatment,the SAS score of group C (respectively (42.79 ± 5.82) points,(33.86 ± 5.05) points) and the SAS score of group B (respectively (49.93 ± 6.63) points,(40.93 ± 6.46)points) were lower than those of group A (respectively (55.86 ± 5.46) points,(53.93 ± 6.03) points),and there were significant differences among the three groups(P ＜ 0.05).Conclusion There is no significantly improvement in patient's anxiety after coronary revascularization.Anti-anxiety drug and psychological intervention significantly improve the patient's negative emotions and reduce the incidence of angina.

Biomechanical properties of a magnesium alloy absorbable rib intramedullary nail / 中国组织工程研究

BACKGROUND: At present, the materials that are successful y applied in rib fracture internal fixation mainly include titanium, nitinol rib encircling bone bonding plate, imported poly-L-lactic acid absorbable rib nails and anatomical plate. OBJECTIVE: To study the biomechanical characteristics of new magnesium al oy absorbable rib intramedul ary nail in the rib fracture fixation, and to compare with imported poly-L-lactic acid absorbable rib intramedul ary nail in order to provide scientific basis for clinical application. METHODS: Thirty fresh adult fifth rib specimens were col ected, and the specimens were used to make models for the middle rib fractures. The specimens were fixed with AZ31B magnesium al oy absorbable rib intramedul ary nail (magnesium al oy group) and poly-L-lactic acid absorbable rib intramedul ary nail (poly-L-lactic acid group), and the normal rib specimen group was set as control. The biomechanical characteristics of the nails in each group were tested with stress analysis. RESULTS AND CONCLUSION: Three-point bending strength measurement results showed that the bending strength in the magnesium alloy group was close to the normal value of the specimen (P > 0.05), and there was significant difference in the bending strength between magnesium alloy group and the poly-L-lactic acid group (P < 0.05). Torsional strength measurement showed that there was no significant difference in torsional strength between magnesium alloy group and the normal specimens, and the results showed that the magnesium alloy was better than poly-L-lactic acid in fixation (P < 0.05). Tensile tests showed that the tensile strength and anti-pulling force of the magnesium alloy fixation were better than those of poly-L-lactic acid fixation (P < 0.05). The results indicate that the magnesium alloy absorbable rib intramedullary nail is better than poly-L-lactic acid absorbable rib intramedullary nail in strength and tensile strength, which is the ideal fixation material for rib fixation.

The relationship among the attention function, coping style and depression symptoms in depression disorders / 中华行为医学与脑科学杂志

Objective To explore the relationship of attentional function,coping style and depressive symptoms in depression disorders.Methods Sixty-eight depression disorder and seventy-one normal healthy people were assessed by Hamilton depression scale(HAMD),coping style questionnaire and digit span forward.Independent samples t test and hierarchical multiple linear regression analysis were used to analyze all data.Resuits Compared with the control group,depressed patients had higher blaming(0.57 ± 0.29 vs 0.29 ± 0.25,P ＜0.01),wishful thinking(0.55 ± 0.22 vs 0.42 ± 0.26,P ＜ 0.01) and avoidant (0.63 ± 0.18 vs 0.46 ± 0.21,P ＜0.0l),lower problem solving (0.67 ± 0.23 vs 0.80 ± 0.18,P ＜ 0.01),rationalization (0.51 ± 0.20 vs 0.59 ±0.06,P＜0.01) and poorer attentional function(6.90 ± 1.65 vs 7.54 ±0.98,P＜0.01) ;but there was no significant differences in support seeking score.Hierarchical multiple linear regression analysis revealed that,even when controlling for age,sex,low score of support seeking were independently predicted attentional function impairment (β =-0.25,P＜0.05).In addition,the use of support seeking was found to mediate the relationship between digit span forward and retardation completely.Conclusion Retardation indirectly influence the attention function by the mediating of support seeking.

Effects of type D personality on anxiety, depression and quality of life of hospitalized patients with coronary heart disease / 中华行为医学与脑科学杂志

Objective To explore the relationship between type D personality,anxiety and depression of coronary heart disease(CHD) and the effects on quality of life (QOL).Methods 296 CHD patients were randomly chosen to answer the questionnaires of general situation,type D personality scale (DS14),Self-rating Anxiety Scale(SAS),Self-rating Depression Scale (SDS) and Short-Form Health Survey (SF-36).Results Of all subjects 37.2％ were identified as type D personality,detection rates of anxiety and depression was were higher than the patients with non-type D personality (33.6％ vs 14.0％,49.1％ vs 23.1％,separately) (P＜ 0.01).The scores of role-physical (RP),bodily pain (BP),general health (GH),vitality (VT),social functioning (SF),role-emotional(RE),mental health (MH) in patients with type D personality ((32.73 ± 42.52),(57.68 ± 26.93),(42.14 ±18.23),(47.15 ±22.60),(59.43 ±26.67),(45.91 ±46.22),(49.25 ±22.21),separately) were lower than the patients with non-type D personality ((56.00 ± 46.61),(64.62 ± 22.27),(48.27 ± 19.19),(61.56 ±20.17),(69.70 ± 24.35),(70.79 ± 44.53),(70.52 ± 18.91),separately) (P＜0.05 or 0.01).Multiple stepwise regression analysis showed that depression,type D personality,anxiety,coronary artery stenosis degree and degree of education were entered QOL regression equation(β =-16.31,-6.53,-7.69,-15.75,2.64,P ＜ 0.05).Conclusion The type D personality of CHD exist high prevalence of anxiety and depression disorders,and the type D personality influence the QOL of patients with CHD.

The impact factors analysis of hospitalized patients with coronary heart disease accompanying depression disorders / 中华行为医学与脑科学杂志

Objective To explore the status and impact factors of hospitalized patients with coronary heart disease(CHD) accompanying depression disorders.Methods Adopt HRSD,SDS and general questionnaire for survey tools to evaluate the 300 hospitalized patients with CHD.Using SPSS13.0 software to build database,and the data was analyzed by descriptive statistics analysis and correlation analysis.Result There were 148 people accompanying depression disorders among the hospitalized·patients with CHD(47.30％ ),and 68 people were treated (47.89％).Multivariate logistic regression indicated that the age ( OR =-0.415,P ＜ 0.05,CI =0.443 ～0.984),smoking history( OR =0.384,P ＜ 0.05,CI =1.118 ～ 1.928 ),course of disease ( OR =-0.250,P ＜0.05,CI =0.608 ～ 0.996),myocardial infarction ( OR =0.676,P ＜ 0.05,CI =1.082 ～ 3.576 ),family history ( OR =-0.744,P ＜ 0.05,CI =0.231 ～ 0.978 ) were related to coronary artery disease accompanying depression disorders.Multivariate correlation analysis indicated that anxiety factor and gender were closely related,weight factor and age,educational level,myocardial infarction had closed relationship,cognitive factors were closely associated with the course of disease,day and night changes were in relation to age,block factor and gender,age,education,drinking history,smoking history were related closely,sleep factor and gender,onset form,hypertension relations closed,despair factor have closed relationship with gender,age,educational level,course of disease.Conclusion Age,smoking history,course of disease,myocardial infarction,family history were important risk factors of depression disorders in hospitalized patients with CHD.The HRSD's seven symptoms factors are closely associated with multipling influence factors.

A1 H magnetic resonance spectroscopy study of obsessive-compulsive disorder / 中华行为医学与脑科学杂志

Objective To approach potential abnormalities of neuro-chemical compounds in cerebrum of obsessive-compulsive disorder and to analyze the relationship among the abnormalities with duration of illness and symptom severity. Methods 19 patients with obsessive-compulsive disorder and 22 comparison subjects were scanned by 1H magnetic resonance spectroscopy to exam bilateral prefrontal lobe, temporal lobe, parietal lobe, occipital lobe, anterior cingutate and caudate nucleus, hippocampus as well as splenium and genu of corpus callosum,thalamus. The ratios of N-acetylaspartate (NAA) and choline (Cho) to creatine (Cr) were respectively recorded.The severities of obsessive-compulsive symptoms were assessed by Yale-Brown Obsessive-Compulsive Scale. Results ( 1 ) The ratios of NAA/Cr in right caudate nucleus and left hippocampus were higher than those in normal controls (1.23 ±0.37 vs 1.0 ±0.33, t=2.14, P=0.039;1.34 ±0.25 vs 1. 10 ±0.45, t=2.41, P=0.021 ), but NAA/Cr ratios in genu of corpus callosum were lower(0. 97 ±0.30 vs 1.19 ± 0. 26, t = -2.47, P= 0.018 ).(2) The Cho/Cr ratios in right caudate nucleus and left temporal lobe were higher than those in control groups (1.09±0.51 vs0. 67±0.21,t=3.32, P=0.003;2.58±0.62vs0.84±0.17, t=2.21,P=0.03). (3) The duration of illness was negatively correlated with the Cho/Cr ratios of right prefrontal lobe ( r = - 0. 507, P =0. 027 ). (4) The NAA/Cr ratios of genu of corpus callosum as well as the Cho/Cr ratios of left temporal lobe were negatively correlated with YBOCS score ( r 1 = - 0.457, P = 0.049; r 2 = - 0. 585, P = 0.009 ). Conclusion Neuronal functions increase in right caudate nucleus and left hippocampus which are opposite in genu of corpus callosum. These abnormalities may play an important role in pathogenesis of OCD.

The interaction analysis of genetic and behavioral factors on the occurrence of acute coronary syndrome / 中华行为医学与脑科学杂志

Objective To explore the the interaction analysis of genetic and behavioral factors on the occurrence of acute coronary syndrome. Methods This study consisted of 134 subjects between June 2009 and Dec.2009 from affiliated hospital of Jining Medical University, All subjects underwented selective coronary angiography or coronary artery CT. Coronary artery disease based on the results of coronary angiography or coronary artery CT that at least one coronary artery diameter reduction of more than 50% and fulfilled the diagnostic criteria of ACC/AHA. 84 patients with acute coronary syndrome and 50 controls, and general informations, current disease history,past medical history, related be havioral factors were collected. DNA was extracted from acute coronary syndromepatients and healthy control subjects, stored in -20 ℃. The genotype of CFH Y402H was detected by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) methods in acute coronary syndrome patients and controls. PCR amplification products was verificated by electrophoresis on agarose gel. Deviation of genotype distribution form Hardy-Weinberg equilibrium was assessed using x2 test in each group. Univariate and multivariate conditional logistic analyses were conducted in the end. Results The results showed that smoking history (P=0.000, OR =4.894,OR 95% CI:2.537 ～9.441 ), alcohol drinking history(P= 0.008,OR =2.879,OR 95% CI: 1.499 ～ 5.528 ), hypertension (P = 0.000, OR = 4.222, OR 95% CI: 2.195 ～ 8.123), sports activities (P =0.002,OR =0.333, OR 95% CI:0.188 ～ 0.589 ), salt intake (P= 0.006, OR = 0.457, OR 95% CI:0.287 ～0.727 ), character(P = 0.000, OR = 0.385, OR 95% CI :0.247 ～ 0.600 ) stress of occupations (P = 0.015, OR =2.118, OR 95% CI: 1.278 ～ 3.511 ) were associated with acute coronary syndrome of Northern Chinese Han population. Smoking history(P = 0.010, OR = 6.084, OR 95% CI: 1.543 ～ 23.988), hypertension (P= 0.024, OR =2.821, OR 95% CI: 1.143 ～ 6.595 ), sports activities (P= 0.004, OR = 0.297, OR 95% CI:0.130 ～ 0.678 ), personality(P= 0.011, OR = 0.435, OR 95% CI:0.229 ～ 0.829 ) were significantly associated with acute coronary syndrome in multivariate conditional logistic analyses after adjusting other factors. Conclusions Smoking history,hypertension, personality are risk factors of acute coronary syndrome of Northern Chinese Han population. Butsports activities is protective factors.

The correlation study about type A and type D personality with coronary heart disease / 中华行为医学与脑科学杂志

Objectives To explore the effect of type A personality and type D personality on coronary heart disease (CHD) ,and the influence of the two kinds of personality factors with the risk factors of CHD. Methods 123 CHD patients and 116 healthy subjects were randomly chosen to answer the questionnaire of general situation and type A behavior questionnaire(TABQ) and type D personality scale(DS14) and assay the fasting glucose ( GLU ), total cholesterol ( TC ) and triglycerides ( TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) ,very low density lipoprotein (VLDL). Results ( 1 )The detection rate of type A personality were respectively 66.7% in CHD group and 40.5% in control group,while type D personality were respectively 39.8% in CHD group and 22.4% in control group (P ＜ 0. 05 ). ( 2 ) There were significant differences in total TABPQ,TH, CH , SI, NA scores between the two groups(P＜ 0.05 ). (3)Coronary heart disease had correlated with gender,history of hypertension, HDL, LDL, GLU and negative affectivity. Conclusion Negative affectivity plays an important role in CHD.