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Objective:To conduct a systematic review and Meta-analysis of the efficacy and safety of Apatinib and tegafur in colonic cancer.Methods:With "Apatinib" "Tegafur" "Colonic cancer" as keywords, PubMed, Embase, Web of Science, Cochrane Library, WanFang Data, VIP, CNKI and CBM were searched from inception to December 2020 to collect randomized controlled trail about treatment for colonic cancer with Apatinib and Tegafur. Evaluated the portion remission and stable duration and progression-free survival. Meta-analysis was performed by using RevMan 5.3 software.Results:Meta-analysis showed that in colonic cancer patients, the portion remission and stable duration, tumor progression of Apatinib were not inferior to those of Tegafur ( RR=1.10, 95% CI: 0.71-1.71, P=0.640; RR=0.51, 95% CI: 0.28-1.32, P=0.205). But for progression-free survival, Apatinib was superior to Tegafur in overall patients( SMD=0.90, 95% CI: 0.42-1.37, P<0.000 1). Conclusion:In the treatment of colon cancer, compared with Tegafur, Apatinib can effectively improve the progression-free survival and has better overall survival.
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Helicobacter pylori (HP) is a kind of gram-negative bacillus parasitizing in human gastric mucosal tissue,which coevolved with human body.HP is one of the most genetically diverse bacterial species,which is mainly attributed to its high mutation and recombination rate.After tens of thousands of years of historical evolution,HP experienced numerous genetic polymorphisms and adaptive evolution in order to maintain a relatively stable colonization relationship with human hosts,making it became one of the species with the largest genome variation among prokaryotes.With such a long history with human beings,HP can be used as reference information for human migration in a sense.With the development of biological information technology,multilocus-sequence typing (MLST) technology plays a great role in the study of the evolution of bacterial strains.It has the characteristics of high repeatability and resolution,and the analysis results can be compared between different countries and laboratories.This paper mainly reviews the research and application progress of MLST technology in the genetic evolution of HP.
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Objective To systematically investigate the clinical efficiency and safety of ligation of inter sphincteric fistula tract versus incision-thread-drawing procedure for complicated anal fistula.Methods Searched PubMed,The Cochrane Library,CNKI,WanFang Data,and VIP from inception to May 2016,to collect randomized controlled trials of ligation of inter sphincteric fistula tract versus incision-thread-drawing procedure for complicated anal fistula.Search term included ligation of inter sphincteric fistula tract,fistula,incision-thread-drawing procedure,randomized controlled trial.The literatures were screened according to inclusive criteria,data were extracted and the quality of included studies was evaluated,and then meta-analysis was performed using RevMan 5.2 soft ware.A total of 5 randomized controlled trials including 305 patients were included.Results The results of meta-analysis showed that compared with incision-thread-drawing procedure,ligation of inter sphincteric fistula tract had a significant difference in amount of bleeding during surgery (MD =-18.30,95％ CI:-19.91 ～-16.69,P ＜ 0.000 01),the duration of pain (MD =-4.38,95％ CI:-4.69 ～-4.08,P ＜ 0.000 01),healing time (MD =-10.28,95％ CI:-15.71 ～-4.86,P =0.0002),hospital stay (MD =-7.44,95％CI:-10.87～-4.02,P＜0.000 1),recurrence rate (OR=0.31,95％CI:0.10～0.91,P=0.03).There was no significant difference in Operation time (MD =-5.83,95 ％ CI:-7.64 ～-4.02,P ＜ 0.000 01),effective percentage (OR =4.35,95％ CI:0.89 ～ 21.32,P =0.07) between both groups.Conclusion Compared with incision-thread-drawing procedure,ligation of inter sphincteric fistula tract shows significant advantage in cure rate,postoperative healing time,reducing post-operation pain,anal function protection and recurrence rate.
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Metastasis-associated in colon cancer-1 (MACC1) is a recently discovered gene associated with colon cancer metastasis,there is significant relationship indicated from some studies between MACC1 and different malignant tumors.It may play an important role in the regulation of tumors metastasis.This article reviewed the expression and regulating function of MACC1 in different cancers including colorectal cancer,hepatic cancer,gastric cancer,lung cancer,ovarian cancer,breast cancer,and so on.It may offer clues to find a new target for target treatment of cancer metastasis.
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<p><b>OBJECTIVE</b>The objective was to review the factors affecting the feasibility of performing successful laparoscopic colectomy.</p><p><b>DATA SOURCES</b>The literatures about the risk factors closely related to the ability to perform laparoscopic colectomy on different surgical diseases of the colon cited in this review were obtained from PubMed published in English from 2006 to 2012.</p><p><b>STUDY SELECTION</b>Original articles regarding the risk factors that affect the ability to perform laparoscopic colectomy were selected.</p><p><b>RESULTS</b>Obesity, diabetes, inflammatory bowel diseases, advanced age, emergency operation, and pelvic anatomy are all important risk factors that increase the risk of developing serious complications such as hemorrhage, anastomotic leak, and skin and soft tissue infections following laparoscopic colectomy. These factors also increase the likelihood of conversion to an open operation. In this study, we reviewed the recent original articles about the relationship of laparoscopic colectomy with these risk factors. We also describe some strategies that limit the likelihood of these complications and the likelihood of conversion to an open operation.</p><p><b>CONCLUSIONS</b>Obesity, diabetes, inflammatory bowel diseases, age, emergency operation, and pelvic anatomy are all important risk factors that increase the risk of either serious complications or conversion to open operation with laparoscopic colectomy. Evaluation of these risk factors preoperatively should influence the decision to perform colectomy using laparoscopic techniques.</p>