CARBOXYLIC DERIVATIVES OF SUBERGORGIC ACID AND THEIR TOXICOLOGY / 中国海洋药物

Six new sesquiterpenoid compounds of nerve-activity were synthesized from a gorgonian neurotoxin -subergorgic acid (1). Toxicological studies and structural correlation with toxicity reveal that subergorgic acid may act on cholinesterase and make a reversible inhibition of its activity of hydrolysis.

ADVANCES IN STUDIES OF SUBERGORGIC ACID / 中国海洋药物

Subergorgic acid is one of marine neurotoxins. It has a unique chemical structure. This article reviews its isolation and structural determination, total synthesis,derivatives preparation,biologic activities and potential applications.