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Objective To explore the short-term influences of conventional internal medical treatment combined with escitalopram on cognitive function and cardiac function in elderly patients with chronic heart failure (CHF) complicated with depression disorder.Methods A total of 97 patients with CHF complicated with depression disorder in Chongqing Ninth People's Hospital,from October 2014 to October 2015,were selected and randomly divided into the antidepressant group and control group.Both groups were undergoing conventional internal medical treatment.Additionally,patients in the antidepressant group were administrated with escitalopram,while patients in the control group were treated with placebo.The degree of depression and anxiety and cognitive function were assessed by using 24-item Hamilton depression scale (HAMD-24),14-item Hamilton anxiety scale (HAMA-14) and Montreal cognitive assessment(MoCA) scale,and the plasma level of NT-proBNP,left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF) were measured before and after 6-week treatment.Results After 6-week treatment,the HAMD-24 and HAMA-14 scores and plasma level of NT-proBNP in antidepressant group were lower than those in the control group,while the attention score and LVEF were greater than those in the control group,there were statistically significant differences(P＜0.05).After 6-week treatment,no statistically significant difference was found in other observed indicators between the two groups(P＞0.05).Conclnsion For elderly patients with chronic heart failure complicated with depression disorder,it is indicated that escitalopram could not only relieve their anxiety and depression,but also improve their cardiac function and attention.
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Objective To investigate the effect of the reduction of serum uric acid(SUA) on blood pressure(BP) control and re‐nal function protection in hypertensive patients with asymptomatic hyperuricemia (HUA) .Methods One hundred and forty‐eight hypertensive patients with asymptomatic HUA were randomly divided into two groups ,namely HUA reduction group and control group .Patients in HUA reduction group was provided with benzbromarone and low purine food ,while patients in control group was given placebo and ordinary diet .All patients were given the same method of antihypertensive drugs .Follow up was preformed for 6 months ,data of BP ,SUA ,creatinine(Cr) ,creatinine clearance(Ccr) ,24 h microalbuminuria quantity(MAU) ,serumβ2 microglobulin (β2‐MG)and adverse reactions were recorded and analyzed .Results The systolic blood pressure(SBP) and diastolic blood pressure (DBP) of patients in HUA reduction group significantly decreased immediately after being treated ,while SUA decreased 1 month after being treated .Compared with control group ,the average SBP and DBP of patients in HUA reduction group was significantly lower 3 months after being treated;the SUA was significantly lower 1 months after being treated ,the levels of Cr ,Ccr ,MAU andβ2‐MG was significantly lower at 3 months and 6 months after being treated (P<0 .05) .Conclusion The SUA therapy can effec‐tively lower BP and SUA levels of primary hypertensive patients with asymptomatic HUA while protecting renal function .
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0.05).After 3 months,the HDL-C level increased by 31.7% in treatment group and 8.7% in control group(P
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Objective: To investigate the efficacy and safety of clinical use of sodium nitroprusside.Methods: The data of 3894 hospitalized patients who had ever been treated with sodium nitroprusside between 1995 and 2004 in our hospital were retrospectively collected.The therapeutic dose,time of therapy,effective rate and side effect were assessed.Results: The minimum time of continuous infusion with sodium nitroprusside was 0.5hour,the maximum 368 hours,average 125.5?24.2 hours.The minimum dose of sodium nitroprusside infusion was 0.2?g/(kg?min),the maximum 9.8?g/(kg?min),average 3.1?1.9?g/(kg?min).The minimum dose of continuous infusion was 2.5mg,the maximum 2050mg,average 210?26.7mg.Among the 3894 patients,3524 cases were effective,accounting for 90.4%;278 cases were ineffective,accounting for 7.1%;95 cases were death,amounting 2.4%,among which the cases caused by ssodium nitroprusside toxicity accounted for 0.02%.The total incidence of caused by sodium sodium nitroprusside toxicity accounted for 0.02%.The total incidence of common side effect was 13.7%.The incidence of hypotention,rebound and tolerance were 10.2%,3.2%,and 0.3% respectively,which might be prevented by some protective measures.Conclusion: It is effective and safe for patients to undergo treatment with sodium nitroprusside.Sever toxicity is rare.Although the common side effect is frequent,but it can be controlled.