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Objective:To investigate the expression and clinical significance of endostatin (ES) and angiostatin (AS) in pterygium.Methods:From January 2016 to December 2018, 60 cases (60 eyes) of pterygium tissue and 60 cases (60 eyes) of normal human conjunctival tissue were selected from the eye surgery of Traditional Chinese Medicine Hospital of Yiwu.HE staining was used to observe the morphological changes of pterygium and normal conjunctival tissue.Western blot was used to measure ES and AS protein levels in the tissues of pterygium group and control group.Results:HE staining showed that in the normal bulbar conjunctival tissue, the stromal layer was connective tissue and the epithelial layer was columnar epithelium; in the pterygium, the basal layer had a large number of new blood vessels, fibroblasts, collagen fibers, and inflammatory cells infiltrated around the blood vessels; the epithelium showed different degrees of hyperplasia.The protein levels of ES and AS in pterygium tissues[(0.35±0.12), (0.62±0.17)] were higher than those in the control group [(0.13±0.08), (0.16±0.09)]( t=11.816, 18.524, P=0.000, 0.000). The protein levels of ES and AS in the pterygium tissues of the recurrent group [(0.63±0.15), (0.87±0.21)] were higher than those in the initial group [(0.22±0.11), (0.45±0.16)]( t=17.073, 12.323, P=0.000, 0.000). There was positive correlation between ES and AS in pterygium ( r=0.571, P=0.000). Conclusion:The levels of ES and AS in pterygium tissue are increased, and ES and AS may be involved in the occurrence and recurrence of pterygium.
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Objective To study the effect of pranoprofen combined with 0.3% hyaluronic acid sodium eye drops on dry eye after cataract surgery.Methods From July 2016 to June 2018,80 patients with dry eye after cataract surgery in the Traditional Chinese Medicine Hospital of Yiwu were selected study objects , and they were randomly divided into control group and observation group by double blind random assignment method ,with 40 cases in each group.The control group was treated with pranoprofen eye drops alone ,while the observation group was treated with pranoprofen eye drops combined with 0.3% hyaluronic acid sodium eye drops.The lacrimal gland secretion , corneal fluorescein staining ( FL) and corneal rupture time (BUT) were observed before and after treatment in the two groups.The improvement of dry eye symptoms ,ocular surface signs score and life satisfaction were observed in the two groups.Results There were no statistically significant differences in lacrimal gland secretion test ,FL and BUT test before treatment between the two groups ( all P＞0.05).The lacrimal gland secretion test ,BUT and FL in the control group were (6.44 ±0.32)mm／5 min,(1.60 ±0.45),(4.31 ±0.23)s,respectively,which in the observation group were (9.03 ±0.86)mm／5 min,(0.66 ±0.25),(5.20 ±0.33)s,respectively,the differences were statistically significant(t＝17.79,11.43,13.59,all P＜0.05).In the control group,significant improvement in dry eye symptoms observed in 26 cases,slightly improved in 9 cases,no improvement in 5 cases,which in the observation group were 32 cases,8 cases,0 case,and there was statistically significant difference between the two groups (Z＝0.342,P＝0.006).Ocular surface signs analysis :before treatment,the score of the control group was (3.61 ±1.33) points, which of the observation group was (3.65 ±1.27)points,the difference was not statistically significant (P＝0.051); after treatment,the score of the control group was (1.97 ±1.21)points,which of the observation group was (1.32 ± 0.91)points,the difference was statistically significant (t＝4.673,P＝0.003).Life satisfaction score:after 1, 2 and 3 weeks of treatment, the control group was (20.62 ±3.17) points,(22.35 ±2.17) points,(29.16 ±3.19) points respectively,and the observation group was (23.32 ±2.16) points,(27.41 ±2.51) points,(33.11 ±4.15) points respectively,the differences are statistically significant between the two groups ( t＝6.29,8.34,6.31,P＝0.002, 0.005,0.013).Conclusion Pranoprofen combined with hyaluronic acid sodium eye drops has significant effect in the treatment of dry eye after cataract surgery.
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Objective@#To study the effect of pranoprofen combined with 0.3% hyaluronic acid sodium eye drops on dry eye after cataract surgery.@*Methods@#From July 2016 to June 2018, 80 patients with dry eye after cataract surgery in the Traditional Chinese Medicine Hospital of Yiwu were selected study objects, and they were randomly divided into control group and observation group by double blind random assignment method, with 40 cases in each group.The control group was treated with pranoprofen eye drops alone, while the observation group was treated with pranoprofen eye drops combined with 0.3% hyaluronic acid sodium eye drops.The lacrimal gland secretion, corneal fluorescein staining (FL) and corneal rupture time (BUT) were observed before and after treatment in the two groups.The improvement of dry eye symptoms, ocular surface signs score and life satisfaction were observed in the two groups.@*Results@#There were no statistically significant differences in lacrimal gland secretion test, FL and BUT test before treatment between the two groups (all P>0.05). The lacrimal gland secretion test, BUT and FL in the control group were (6.44±0.32)mm/5 min, (1.60±0.45), (4.31±0.23)s, respectively, which in the observation group were (9.03±0.86)mm/5 min, (0.66±0.25), (5.20±0.33)s, respectively, the differences were statistically significant(t=17.79, 11.43, 13.59, all P<0.05). In the control group, significant improvement in dry eye symptoms observed in 26 cases, slightly improved in 9 cases, no improvement in 5 cases, which in the observation group were 32 cases, 8 cases, 0 case, and there was statistically significant difference between the two groups (Z=0.342, P=0.006). Ocular surface signs analysis: before treatment, the score of the control group was (3.61±1.33)points, which of the observation group was (3.65±1.27)points, the difference was not statistically significant (P=0.051); after treatment, the score of the control group was (1.97±1.21)points, which of the observation group was (1.32±0.91)points, the difference was statistically significant (t=4.673, P=0.003). Life satisfaction score: after 1, 2 and 3 weeks of treatment, the control group was (20.62±3.17)points, (22.35±2.17)points, (29.16±3.19)points respectively, and the observation group was (23.32±2.16)points, (27.41±2.51)points, (33.11±4.15)points respectively, the differences are statistically significant between the two groups(t=6.29, 8.34, 6.31, P=0.002, 0.005, 0.013).@*Conclusion@#Pranoprofen combined with hyaluronic acid sodium eye drops has significant effect in the treatment of dry eye after cataract surgery.
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Objective Clinical studies of Chronic Nasosinusitis by endoscopic intranasal sinus surgery under head mirror.Methods 43 cases were operatived by endoscopic intranasal sinus surgery under head mirror.Results 29 cases were cured and 14 cases effectived, Efficiency 100.00%. 17 uncinate process residue, There were no severe complications.Conclusion Endoscopic intranasal sinus surgery under head mirror for chron icsinu sit is and nasal polyps can solveo stiom eatalcomplex anom alism more effectively and raise the cure rates of sinusitis (type Ⅰ、Ⅱ) than conventional technique in surgery.This choice will reduce the cost of the patients than Endoscopic sinus surgery, but must be provided with the knowledge in nasal and paranasal sinus, grapple the gist of endoscopic intranasal sinus, strict Surgical indication at the same time.