Correlations between gestational age,birth weight and motor development in children with autism / 中华行为医学与脑科学杂志

Objective To explore the motor development and how it is influenced by gestational age and birth weight in children with autism,and provide evidence for the applications of motor development in the early diagnosis of autism. Methods A 1 ∶ 1 matched case-control study was conducted between 2012 and 2014. A total of 396 children under 5 years old with autism were enrolled in this study,their counterparts were healthy children 3 month younger/ older and with the same gender and residence. Guardians of partici-pants were investigated using self-designed childhood psychological and behavioral development and related factors questionnaire. EpiData 3. 0 software was used to establish the data base and SAS 9. 4 software was used for data analysis. Results 396 pairs were enrolled in this study which including 342 pairs of boys (86. 3%) and 54 pairs of girls(13. 7%),the gender ratio was 6. 33 ∶ 1; The average month age of case group was (39. 44±11. 99) months and (39. 96±12. 24) months for the control group. There was no signifi-cant difference observed in the distribution of birth weight(χ2=3. 888,P=0. 140) and gestational age specif-ic birth weight(χ2=0. 462,P=0. 794)between two groups. But the distribution of gestational age was signifi-cantly different(χ2=9. 476,P=0. 009) . Children with autism have significant delaying in motor develop-ment compared with healthy children at same age,which including head lifting(3. 50(1. 00) month),rolling (6. 00(3. 50)month),sitting(8. 00(2. 50)month),etc. Preterm birth could have an effect on head lifting, rolling and sitting in children with autism,and also was the risk factor of delaying occurrence of head lifting (OR=2. 911,95%CI=1. 491-5. 681);Small for gestational age( SGA) was also a risk factor of delaying in walking(OR=1. 703,95%CI=1. 053-2. 754). Conclusion Evident delaying of motor development is ob-served among children with autism. Both preterm and SGA are risk factors for delayed motor development. Thus,early recognization of abnormities in motor development should raise awareness among caregivers and children care workers and assist in early diagnosis of children with autism.

Effect of aggregation nutrition intervention and psychological intervention combined with compound kushen injection on postoperative patients with esophageal carcinoma / 中国生化药物杂志

Objective To analyze the effect of cluster nutrition intervention and psychological intervention combined with compound Kushen injection on postoperative patients with esophageal cancer. Methods 80 patients with esophageal cancer who underwent postoperative radiotherapy and chemotherapy were divided into two groups. The control group was treated with chemotherapy alone. The observation group was treated with compound bitter ginseng injection and cluster nutrition intervention. Psychological intervention therapy. The total effective rate, the nutritional index before and after treatment, the SF-36 quality of life score and the complication rate were compared. Results The total effective rate and the post-treatment nutritional value of the observation group were higher than those of the control group. After treatment, the SF-36 scale was higher than the control group, the incidence of adverse reactions was lower than that of the control group(P<0.05). Conclusion The combination of intensive nutrition, psychological intervention and compound Sophora flavescens injection can improve the nutritional status, improve the curative effect, reduce the adverse reaction and improve the quality of life of patients with esophageal cancer after radiotherapy and chemotherapy.

Influence of open access journals of biomedicine in China on academic exchanges / 中华医学教育探索杂志

Objective To compare the influence of open access journals ( OAJ ) of biomedicine on academic exchanges by empirically analyzing the journals enrolled in the Chinese science citation database-the core (CSCD-C).Methods Multivariate statistical analysis was performed on OAJ and non OAJ in CSCD by using bibliometric and statistical methods,SPSS software and rank-sum test.Results The OAJ were accounted for only 31.63％ of the total enrolled journals,the average ratio of funded papers in OAJ was 72.29％.Statistical journals had high influence in the discipline.The selfcitation rates of clinical medicine OAJ and special medical OAJ were high.The average impact factor and h index in biological OAJ were high.The average impact factor of preventive medicine OAJ was high.The average h index of comprehensive non OAJ was high.Conclusions The distribution of OAJ is uneven among different disciplines.The ratio of funded papers is higher in OAJ than in non OAJ with insignificant differences in discipline influence.

Observation of bridging operation by an autogenous incus in the ossiculoplasty / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To study the clinical effects of bridging operation by an autogenous incus in the ossiculoplasty.</p><p><b>METHODS</b>All the postoperative follow-up data of the 68 patients were analyzed retrospectively, who underwent bridging operation by an autogenous incus in the ossiculoplasty and were followed up for 6-28 months with an average of 19.75 months. The autogenous incus which had been reshaped was implanted between the intact malleus and the intact mobile stapes. The preoperative and postoperative pure tone average (PTA) air-conduction, bone-conduction and air-bone gap on four frequencies (0.5, 1, 2 and 4 kHz) were calculated and analyzed.</p><p><b>RESULTS</b>No postoperative autogenous includes were extruded with only two cases displaced. The pure tone air conduction improved from a preoperative average of (46.69 +/- 18.32) dB to a postoperative average of (30.21 +/- 9.46) dB, while bone conduction improved from a preoperative average of (24.72 +/- 10.63) dB to a postoperative average of (18.15 +/- 8.91) dB, as well as air-bone gap closed from a preoperative average of 21.97 +/- 10.32 dB to a postoperative average of (12.06 +/- 9.46) dB. The success rate (postoperative PTA-ABG < or = 20 dB) occurred in 75% of all the cases. The improvement of the bone conduction occurred in 66% of all the cases, at least with 10 dB occurred in at least two frequencies.</p><p><b>CONCLUSIONS</b>Because of low expenses, high convenience in an operation, high stability in effects, very low complications and excellent hearing results for the patients, the bridging operation as stated in the above was worthy of choice. The autogenous incus could be utilized if the defects between the intact, mobile stapes and the intact malleus could be well repaired.</p>

Inhibited proliferation and expression of human nasopharyngeal carcinoma line induced by celecoxib in vitro / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To study the effects of celecoxib on the cell proliferation and expression of vascular endothelial growth factor (VEGF) in human nasopharyngeal carcinoma line.</p><p><b>METHODS</b>3-[ 4,5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide (MTT) test was used to investigate the cell proliferation. Flow cytometry (FCM) was used to analyze the cell cycle arrest. Immunocytochemistry technique was to observe the expression of VEGF.</p><p><b>RESULTS</b>Celecoxib inhibited the growth of nasopharyngeal carcinoma line, the cell number of G0/G1 phase increased from 62.13% to 91.35%, and the cell number of G2/M and S phase decreased from 21.59% to 3.56% and from 16.28% to 5.01%, respectively, cell cycle progression was arrested at G1/S phase. Celecoxib decreased the positive expression of VEGF in HNE-1 cells.</p><p><b>CONCLUSIONS</b>Celecoxib inhibited the proliferation of nasopharyngeal carcinoma significantly and the expression of VEGF.</p>

Development and manufacture of WDJ-CP-1 dermabrasive cosmetic instrument / 医疗卫生装备

Objective To develop and manufacture new-type dermabrasive cosmetic instrument and investigate its clinical value.Methods WDJ-CP-I dermabrasive cosmetic instrument was developed by using medical brushless magdyno and then was applied to 296 cases.Results WDJ-CP-I dermabrasive cosmetic instrument had such advantages as small volume,lower noise,long duration of life,simple operation,high-temperature & high-pressure sterilization,safety,high dermabrasive rate,ect.Conclusion WDJ-CP-I dermabrasive cosmetic instrument is a good tool for dermabrasion and is worth popularizing.