The clinical efficacy of small doses of interferon antiviral in treatment of chronic hepatitis with decompensated cirrhosis / 中国现代医生

Objective To study the clinical efficacy of small doses of interferon antiviral in treatment of chronic hep-atitis with decompensated cirrhosis. Methods Forty cases with chronic hepatitis with decompensated cirrhosis were se-lected from our hospital during the period from June 2012 to June 2013,all patients were given ribavirin and small doses of interferon,all patients were followed up 24 weeks after treatment. Results Twenty-nine cases of 40 patients were insisted in antiretroviral therapy,17 patients were treated for 24 weeks,12 patients were treated for 48 weeks. Af-ter treatment, the anorexia and bloating symptoms of 29 patients were vary degrees of ease. The liver function index(ALT,AST,ALB,TB),coagulation (PTA) and virological indicators in 24 weeks were significantly improved,the differ-ence was statistically significant (P<0.05);72 weeks compared with 48 weeks,the liver function index(ALT,AST,ALB, TB), coagulation (PTA) and virological indicators had no significantly improved,the difference was not statistically significant(P>0.05). Conclusion Interferon antiviral has better clinical effect in treatment of chronic hepatitis,and it can improve the liver function.

Dystrophin detection by immunofluorescent technique for diagnosing muscular dystrophy / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To establish a specific technique for diagnosing and classifying Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), facioscapulohumeral muscular dystrophy (FSHD) and neurologic dystrophy.</p><p><b>METHODS</b>Forty-seven cases were detected by immunofluorescence technique for analyzing dystrophin located in skeletal muscle cell membrane with the use of mouse monoclonal antibodies, goat and rabbit polyclonal antibodies.</p><p><b>RESULTS</b>The normal individuals showed ringed positive staining stripe around muscle fibers. Negative result of staining was seen in 16 DMD patients. Eleven BMD patients had discontinuous or a patchy positive staining pattern, and all of 10 FSHD and 10 neurological amyotrophic patients showed positive dystrophin staining.</p><p><b>CONCLUSION</b>Detecting dystrophin in the skeletal muscle cell membrane of muscular patients is an efficient technique for diagnosing and classifying various types of muscular dystrophy.</p>