RESUMO
Three new thionic compounds, ()-2-(2-carboxyl-2-hydroxyethylthio)-ferulic acid (), ()-2-methoxy-4-(3-(methylsulfonyl)prop-1-en-1-yl)phenol (), and thiosenkyunolide C (), together with two new aromatic glycosides ( and ) were isolated from the rhizome of Hort. Two known compounds ( and ) were also obtained. Their structures were elucidated based on extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HR-ESI-MS). Furthermore the absolute configurations were established by comparison of their calculated and experimental circular dichroism spectra and by a dimolybdenum tetraacetate [Mo(AcO)]-induced circular dichroism procedure. All compounds were evaluated against lipopolysaccharide (LPS)-induced NO production in BV2 cells, and compounds and showed strong inhibitory activities with IC values of 2.03 and 3.09 µmol/L, respectively (positive control curcumin, IC = 6.17 µmol/L). In addition, compound showed weak proteintyrosine phosphatase-1B (PTP1B) inhibitory activity.
RESUMO
Two new compounds, named lyciumlignan D () and lyciumphenyl propanoid A (), along with seven known compounds, were isolated from the root bark of. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds-were isolated from this genus for the first time. In theassay, compounds,, andexhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
RESUMO
Thirteen compounds were isolated from the flowers of Chrysanthemum indicum by chromatographic techniques. Their structures were elucidated by spectroscopic methods as acacetin-7-0-beta-D-glucopyranoside (1), luteolin (2), luteolin-7-O-beta-D-glucopyranoside (3), acaciin (4), acacetin 7-0-(6"-0-alpha-L-rhamnopyranosyl)-beta-sophoroside (5), 3-0-caffeoylquinic acid (6), syringaresinol 0-beta-D-glucopyranoside (7), 5,7-dihydroxychromone (8), uracil (9), p-hydroxybenzoic acid (10), 4-0-beta-D-glucopyranosyloxybenzoic acid (11), boscialin (12), blumenol A (13). Compounds 5, 7, 8, 11-13 were isolated from C. indicum for the first time.
Assuntos
Chrysanthemum , Química , Flores , Química , Compostos OrgânicosRESUMO
<p><b>OBJECTIVE</b>To study the chemical constituents from the leaves of Sterculia foetida.</p><p><b>METHOD</b>Compounds were isolated by chromatographic techniques. Their structures were elucidated by spectroscopic methods.</p><p><b>RESULT</b>Eight compounds were identified as 5,7,8-tetrahydroxy-4'-methoxyflavone-8-O-beta-D-glucoside (1), 5,7,8-tetrahydroxy-4'-methoxyflavone-7-O-beta-D-glucoside (2), quercetin-3-O-beta-D-glucoside (3), apigenin-6, 8-di-C-beta-D-glucoside (4), puerarin (5), 5,7,8,3'-tetrahydroxy-4'-methoxyflavone (6), 5,7,8-tetrahydroxy-3',4'-dimethoxyflavone (7), 5,7,8-tetrahydroxy-4'-methoxyflavone (8).</p><p><b>CONCLUSION</b>Compounds 1, 2 and 4-8 were isolated from this plant for the first time.</p>
Assuntos
Extratos Vegetais , Folhas de Planta , Química , Sterculia , QuímicaRESUMO
Aim To study the chemical constituents of Rhododendron ovatum Planch. Methods The chemical constituents were isolated and purified by silica gel column chromatography and identified on the basis of their physiochemical and spectral data. Results Seven compounds were isolated and identified. Their structures were established as 3,5,7-trihydroxylchromone 3-O-β-D-xylopyranoside (I), taraxerol (II), β-sitosterol (III), betulinic acid (IV), quercetin (V), quercetin-3-O-α-L-rhamnopyranoside (VI), and D-glucose (VII). Conclusion Compound I is a new compound. Compounds II-VII were isolated from this plant for the first time.