RESUMO
Chronopharmaceutics is a branch of pharmaceutics devoted to the design and evaluation of drug delivery systems that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given disease therapy. A major objective of chronotherapy in the treatment of several diseases is to deliver the drug in higher concentrations during the time of greatest need according to the circadian onset of diseases or symptoms.. The main objective of the present study was to develop single-unit floating-pulsatile drug delivery system for obtaining no drug release during floating and in the proximal small intestine followed by pulsed drug release in distal small intestine to achieve chronotherapeutic release of aceclofenac for treatment of rheumatoid arthritis, osteoarthritis, spondylytis and to improve the patient compliance.