RESUMO
OBJECTIVE: To study the anti-thrombotic, choleretic and anti-ulcerous actions of Rhizoma Ligustici.METHODS: Experiments were carried out on conventional models of choleresis and ulceration, and on a thrombotic model of using direct current continuously to stimulate the unilateral carotid artery of anesthetic rat.RESULTS: Alcoholic extract of Rhizoma Ligustici 3g herb/kg and 10g herb/kg id or ig, increased choleresis and prolonged the time for arterial thrombosis induced by electric stimulation in rats, but did not prolonged coagulative time, PT and KPTT.The extract 5g herb/kg and 15g herb/kg ig, inhibited the formation of gastric ulcers induced by water immersion, stress, HCl and indomethacin-alcohol in mice.CONCLUSION: Rhizoma Ligustici has anti-thrombotic choleretic and anti-ulcerous actions.