RESUMO
Polycystic ovary syndrome [PCOS] is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exists on the relative correlation between omentin-1 with other adipokines or the expression and regulation of omentin-1 in the serum of women with PCOS. The objective of this study is to evaluate the role of omentin-1 levels or omentin-1/adipokines ratio in the serum of women with PCOS compared with matched control subjects. The study involved 60 patients with PCOS and 30 women without PCOS who were used as controls. To examine the relationship between fasting serum omentin-1 and serum interleukin-6 [IL-6], interleukin-8 [IL-8], resistin, ghrelin, leptin RBP-4 and tumor necrosis factor-alpha [TNF-alpha] levels in infertile PCOS and non-PCOS subjects. Also, insulin and other hormones were measured in both groups. All these factors were measured by enzyme-linked immunosorbent assays. From the total of 60 cases, there was a significant increase [p<0.001] in PCOS patients when compared to the control group in fasting serum, serum interleukin-6 [IL-6], interleukin-8 [IL-8], resistin, leptin RBp-4, tumor necrosis factor-alpha [TNF-alpha] levels and insulin. A significant decrease in omentin-1 and ghrelin [p<0.001] was observed. The results also showed that 93.33% and 98.30% in PCOS patients had abnormal omentin 1: Insulin ratio and omentin 1: Resistin ratio respectively according to the cut off values