Prevention of fall in platelet count by carica papaya leaf juice in carboplatin induced thrombocytopaenia in mice

There are no effective methods to treat thrombocytopenia once it occurs. Transfusions, growth factor injections and bone maiTow transplant have their limitations. So there is increased need for research of drugs that could prevent and treat thrombocytopenia. The objective the study to deter-mine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced thrombocytopenia in mice. A total of 55 Swiss albino mice were randomly divided into five groups [C, M[10], M[5], F[10] and /y. Thrombocytopaenia was induced in all groups by a single intraperitoneal injection of carboplatin. Male papaya leaf juice was given to prevent of thrombocy topaenia to groups M[w] and M[5] and female papaya leaf juice was given to F[w] and F[5]. On days o, 7,14 and 21 blood samples were collected by cardiac puncture for platelet count. Significance of difference was calculated by one wayANOVA. After carboplatin injection, platelet count decreased. Papaya leaf juice prevented fall in platelet count throughout the study period with p-value < 0.001. Difference between male and female papaya leaf juice was not significant while higher dose [10 ml/kg] produced significantly higher responses as compared to low dose [5 ml/kg]. Papaya leaf juice prevents reversible thrombocytopaenia induced by carboplatin in a dose dependent manner. There is no difference between male and female plants in this respect

effect of crataegus [hawthorn] extract alone and in combination with simvastatin on serum lipid profile in hyperlipidemic albino rats

Cardiovascular diseases are the most common causes of death in first world countries. Hyperlipidemia is one of the high risk factors for cardiovascular diseases. Crataegus monogyna has acquired an eminent position in remedies for hyperlipidemia. Study Design: It is a case-controlled interventional study of eight weeks' duration. Sample: 100 adult male albino rats weighing about 250-300g divided randomly into five groups A, B, C, D and E. Crataegus is as effective in lowering cholesterol as simvastatin. However, when compared with combination of Crataegus and simvastatin, Crataegus alone was found to yield better results. Both of the drugs are equally effective in lowering triglycerides. HDL level significantly increases in all groups whereas LDL level decreases in groups C, D and E. However only group E was close to normal control group A. Crataegus shows tremendous potential as natural lipid lowering agent, devoid of side effects. In future there is scope in study and use of this 'miracle herb' as anti-hyperlipidemic agent

Evaluation of safety of Tobramycin and Piperacillin combination on rabbit kidney

Tobramycin, an aminoglycoside, and piperacillin, an antipseudomonal penicillin, are widely used to treat Gram -ve infections. Their concurrent use is recommended because of their synergistic action and prevention of resistant strains against monotherapy. This experimental work was aimed to study the effects and interaction of these important drugs on rabbit kidney. Male rabbits were administered tobramycin, piperacillin, and tobramycin plus piperacillin for 21 days [n = 6 in each group]. Blood and urine samples were collected on day O, 11, and 21. Blood was analyzed for BUN, serum creatinine, serum potassium, and serum sodium while urine was analyzed for urine volume, creatinine, albumin and specific gravity. Renal creatinine clearance was calculated. Results showed some change in renal function with use of tobramycin but piperacillin neither changed the renal function nor did augment the toxic effect of tobramycin so it was concluded that combination of both drugs in safe