1.
Chinese Journal of Endocrinology and Metabolism
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-676621
RESUMO
U937 macrophages were cultured with various concentrations of glucose and/or insulin for 24 h.Cell membrane scavenger receptor(SR)-BⅠprotein and mRNA were detected by Western blot and RT-PCR. The results showed that basal physiological insulin levels promoted SR-BⅠprotein expression of macrophages and high concentration of insulin significantly downregulated SR-BⅠ,but the transcription of SR-BⅠmRNA did not change.High glucose and high insulin accelerates atherosclerosis through synergetically downregulating SR-BⅠprotein expression,which may cause early onset and rapid progression of atherosclerosis in the patients with metabolic syndrome and type 2 diabetes mellitus.