Analysis of Pathological Biopsies in 1782 Cases in Dongguan Region / 实用儿科临床杂志

Objective To study the onset features and axiom of children disease in Duanguan region.Methods A statistic study was carried on 1 782 cases of children disease which confirmed by pathological examinations.The sex,age and pathology(congenital malformation,inflammatory disease,tumor-like lesions,benign tumors,malignant tumors)were registered.Results The inflammatory disease occupied the first place in incidence rate(44.61%),followed by tumor-like lesions(25.03%),benign tumors(23.34%),congenital malformation(5.22%)and malignant tumors(1.80%).Among inflammatory disease,appendicitis was the most common,the next was chronic tonsillitis and tuberculosis.Among tumor-like lesions,cystic disease was the most common;the next was polyps.Among benign tumors,vasculoma was the most common,the next was pilomatricoma,osteoid and chonodroid tumors.Among congenital malformation,ear fistula was the most common,the next was diverticulosis and intestineal duplicateion.Among the malignant tumors,the sarcoma of soft tissue was the most common,the next was the malignant peripheral nerve tumors and lymphoma.Conclusion Children's disease have its own characteristics which varied in age,sex and pathological types,and differ from those of adults.

Significance of detection of serum sialic acid and Epstein-Barr virus VCA-IgA in diagnosis and monitoring radiotherapy effectiveness in nasopharyngeal carcinoma patients / 中华实验和临床病毒学杂志

<p><b>BACKGROUND</b>To understand the significance of detection of serum sialic acid (SA) and Epstein-Barr virus VCA-IgA (EBV-CA-IgA) in diagnosis and monitoring radiotherapy effectiveness of nasopharyngeal carcinoma (NPC) patients.</p><p><b>METHODS</b>Serum SA and EBV-CA-IgA were detected in 65 cases with NPC before radiotherapy and one months after radiotherapy and 21 cases one year after radiotherapy for NPC with local recurrence and/or distant metastasis. Healthy persons and patients with benign lesions of head and neck were also enrolled as control group.</p><p><b>RESULTS</b>SA and EBV-CA-IgA of NPC patients before radiotherapy were significantly higher than those in control group (P<0.01). The sensitivity of combination of SA and EBV-CA-IgA (96.9%) was higher than those determined alone (P<0.05). The SA level of NPC patients after radiotherapy and without recurrence after radiotherapy was reduced significantly compared to the NPC patients before radiotherapy (P<0.01). The SA level of NPC patients with recurrence was significantly higher than that in NPC patients without recurrence (P<0.01), whereas the positive rate of EBV-CA-IgA changed little.</p><p><b>CONCLUSION</b>Dynamic detection of serum SA may be a valuable technique for diagnosis and monitoring radiotherapy effectiveness in NPC patients. The combined determination of the two indexes can raise the positive rate of patients with NPC.</p>

Effect of oxymatrine on serum matrix metalloproteinase-2 and its inhibitor in patients with chronic hepatitis B and liver cirrhosis / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and IV type collagen (IV C).</p><p><b>METHODS</b>Changes of all the above-mentioned indexes in patients with CHB (n = 36) and LC (n = 36) before and after treatment were determined, and the relationship of MMP-2 and TIMP-2 with liver fibrosis indexes were analyzed.</p><p><b>RESULTS</b>Oxymatrine could decrease the levels of MMP-2, HA, LN and IV C in patients with severe or moderate CHB and LC of Child-pugh A, B and C grade, as compared with the data before treatment (P < 0.05). Serum level of MMP-2 and TIMP-2 was well correlated with the levels of liver cirrhosis indexes.</p><p><b>CONCLUSION</b>MMP-2 and TIMP-2 can be used as a reference for evaluating the degree of LC, and oxymatrine has a certain anti-LC effect.</p>