RESUMO
Objective To introduce JCI standards into medical consumables management in order to improve the overall management of consumables.Methods Root cause analysis (RCA) method in JCI management standards was used to execute root cause analysis of each key point in medical consumables management.PDCA Cycle was involved in to promote medical consumables management.Results JCI management standardized the path,solved some problems and promoted the level during medical consumables management.Conclusion JCI standards contribute to the standardization and humanization of medical consumables management,and also enhances the patient safety at the same time.
RESUMO
Objective To introduce JCI standards into medical consumables management in order to improve the overall management of consumables.Methods Root cause analysis (RCA) method in JCI management standards was used to execute root cause analysis of each key point in medical consumables management.PDCA Cycle was involved in to promote medical consumables management.Results JCI management standardized the path,solved some problems and promoted the level during medical consumables management.Conclusion JCI standards contribute to the standardization and humanization of medical consumables management,and also enhances the patient safety at the same time.
RESUMO
CD22 is a transmembrane sialoglycoprotein and a member of the immunoglobulin superfamily. Its expression is restricted to the B cell lineage and a vast majority of B cell NHLs. CD22 plays a key role in B cell development, survival, and function. Humanized anti-CD22 antibodies were developed to minimize the immunogenicity and to enhance effector interactions during their developments of diagnostic and immunotherapeutic agent. Preclinical test with anti-CD22 antibodies indicates that a single, conjugated or radiolabeled agent has shown preliminary antitumor activity in patients with recurrent and heavily pretreated NHL. Anti-CD22 antibodies were well tolerated, without dose-dependant toxicity. Anti-CD22 antibodies are currently being evaluated in combination with rituximab, and the early results suggest that the combination of the two antibodies are well tolerated and may result in better clinical activity than the single agent alone. Thus, anti-CD22 antibodies are theoretically good candidates alone and in combination with other drugs in the treatment of B cell malignancies. In this review, the physiologic function and characteristics of CD22 antigen as target molecule of guide therapy for NHL, the types of anti-CD22 antibodies in therapy of NHL and the combination use with other antibodies were summarized.