Effect of trigonella, allium sativum and their mixture on some physiological parameters in hyperthyroidimic rats

Background: alterations in the level of hormones including thyroid hormones lead to physiological/ clinical abnormalities

Aim of work: this study aimed to illustrate the protective effect of Trigonella, Allium sativum or their mixture against hyperthyroidism induced by L-thyroxin in male albino rats

Materials and methods: thirty albino rats were divided randomly into five groups. Group A: healthy rats, Group B: normal rats were subcutaneously injected with 500 micro g/kg body weight L-thyroxin once daily for two weeks to induce hyperthyroidism, Group C: hyperthyroid rats received oral dose of 250 micro g/kg body weight/day Trigonella extract. Group D: hyperthyroid rats received oral dose of 250 micro g/kg body weight/day Allium sativum extract. Group E: hyperthyroid rats received mixture of Trigonella and Allium sativum extract. At the end of the experiment. Blood samples were collected for biochemical analysis

Results: Hyperthyroid rats had significant increase [P<0.05] in serum levels of triodothyronine [T[3]], thyroxin [T[4]], TG, VLDL,AST,ALP,BUN and uric acid as well as a significant decrease in TSH, LDL, HDL, LDL/HDL and TC, total protein and percentage of body weight change compared to the normal control group. Oral administration of these extracts ameliorated most of the tested parameters

Conclusion: This study concluded that Allium sativum,Trigonella or their mixture have a protective effect against hyperthyroidism

[Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion]

Objective: To describe the spectrum of Magnetic Resonance spectroscopy in focal brain lesions and determine its diagnostic accuracy in comparison to conventional MRI using histopathology as gold standard in differentiating various types of focal brain space occupying lesions. New line.

Patients and methods: 52 patients [21 males and 31 females] with single focal brain space occupying lesion diagnosed by post contrast CT or MRI are included in this study. Complete clinical evaluation, MRI, and MRS examination were performed for all these patients before surgical biopsy and/or resection. Correlation of all these findings was done with histopathology obtained in all these patients

Results: The most important markers in differentiating and grading various types of single focal brain space occupying lesion were choline level and choline/N-acetyl aspartate ratio. There is statistically significant difference between mean of Cho/NAA in high grade glioma as it was 23.13 and low grade glioma where mean of choline/NAA was 6.21 [P value = 0.02]. Lipid and lactate peaks were more frequent in high grade tumors and lipid peak together with Choline/N-acetyl aspartate ratio could differentiate between metastasis and metastasis with delayed radiation necrosis. Alanine peak appear to be pathognomonic for meningioma. Perilesional MRS metabolites could detect actual histopathological [subclinical] extension and so differentiate between high grade and low grade tumors and between high grade tumors and metastasis

Conclusion: MRI+MRS is more sensitive than MRI alone in diagnosis, differential diagnosis, and grading of focal brain space occupying lesion. MR spectroscopy could differentiate various types of focal brain space occupying lesion with sensitivity of 92.3% while sensitivity of MRI alone was 76.9%

Impact of chewing Khat on the mode of delivery of Yemeni pregnant women

Khat chewing is common among Yemeni women, even during pregnancy where it may affect the wellbeing during pregnancy and during delivery of these pregnant women. This study was conducted to determine the impact of Khat chewing on the mode of delivery of pregnant Yemeni women. This is a prospective study for 60 regular Khat chewing pregnant women and 120 non-Khat chewing pregnant women, selected from those attended with singleton pregnancy in their first or second trimester from the ANC unit of AL-Gamhouri Teaching Hospital in Taiz [Republic of Yemen]. Khat chewer pregnant women, when compared with the control, showed statistically significant risk of 6.06 times to deliver at gestational age earlier than 37 weeks and insignificant risk of 2.27 times to deliver after 42 weeks. They showed a statistically significant risk of 2.65 times to deliver by cesarean section [CS] and insignificant risk of 4.86 times for instrumental delivery. This study concluded that Khat chewing is associated with higher rate of cesarean and instrumental deliveries that may affect maternal and fetal wellbeing

Kapsoi sarcoma after kidney transplantation: a study of 10 cases from a series of 580 kidney transplantations in a University Hospital in Damascus, Syria

To identify the common causes of injuries among children in this region and suggest preventative strategies. This is a hospital based retrospective review of the files of children under the age of 14 years who presented to the general emergency department at Al-Thawra General Hospital with acute injury and were admitted to the hospital between January 1, 2003 and December 31, 2004. All charts were reviewed for age, sex, place and mechanism of injury, body area injured, and length of stay in the hospital. The total number of children was 421. The mean age was 6.5 years [range 0-14], 62.2% [n=262] were boys and 37.8% [n=159] were girls. The most common trauma type was head injury n=125 [29.7%]. The head injury was of two types; inflicted [intentional] n=112, [89.6%] and traffic accidents [accidental] n=13 [10.4%]. Among the inflicted type, contusion [33.03% in males, 11.60% in females] was the most common mechanism of injury, followed by falls from heights [FFH] 8.92% in males, 5.35% in females, then sharp objects [8.03% in males, 3.57% in females]. Roads were the most common place of trauma in the study, n=256 [60.80%]. In this category, 74[59.2%] of 125 head injuries occurred in roadways. In the age group between 5-10 years, n=182 [43.2%], the commonest cause of trauma was traffic accidents [69.23%]; however, only 13 [10.4%] caused head injuries. The head was the most common body area injured and the main cause of hospital admission [29.69%]. The mortality rate among the children was 35.15% [67.56% male, 32.43% female]. Traffic accidents [RTA], falls, and home injuries are the commonest causes of morbidity and mortality for children in our community. The highest proportions of deaths and severe injuries were observed in the school age group. Prevention strategies must consider this high-risk age group

Anaesthetic management of an epidermolysis bullosa patient undergoing cricopharyngeoesophagoscopy

In this case report, we are describing a young boy with known epidermolysis bullosa who was admitted to the hospital for foreign body removal by cricopharyngeoesphagoscopy. This patient is liable to get bullae formations with any trauma to the skin and mucous membrane, and to avoid this problem we will describe the precautions taken during anaesthetizing this case

Incidence of some congenital malformations [preauricular fistula, protruding ears, microtia, and harelip with cleft palate] in primary school children

Congenital malformations lead to physiological and psychological disability. Early identification help in early intervention and management. This study was conducted on 3916 schoolchild in the period from may 2001 to may 2002 aged between 5-12 years, of both sexes. The aims of this study were: 1] Screening of some congenital malformation such as [preauricular fistula, protruding ears, microtia, and harelip with cleft palate]. 2] Effect of living area and gender in the prevalence of some congenital malformations. The results of its study show that prearicular fistulas was more in rural [0.24%] than urban areas [0.11%] and more in males [5 cases] than females [2 cases]. This study found that the incidence of microtia was [0.05%] only "i" child with unilateral microtia in rural area. Also 1 male child in rural area suffering from harelip with cleft palate. The incidence of protruding ears was more in urban area [6 children 0.33%] than rural area [5 children 0.24%] but with more male affection [8 cases] than female [3] cases. C.T. scan was done to all cases with congenital malformations showing normal middle ear and inner ear structures

Clinical study of continuous interleaved sampler and simultaneous analog stimulation in cochlear implant patients

This study included 15 consequently implanted, postlingually deafened adults. Fifteen patients were initially programmed and tested with both CIS and SAS. All patients were fitted by clarion cochlear implant and stimulated by enhanced bipolar configuration simultaneous analog stimulation [SAS] strategy and continuous interleaved sampler [CIS] strategy. The CIS strategy offered an output-sampling rate of 6.500 pulses per second. The SAS strategy offered a currently implements with an overall rate 104.000 samples per second. Post implant tests included monosyllabic words and sentences in quiet and in noise using digitally recorded speech test. It was concluded that the availability of both ASA and CIS speech processing strategies offers a greater opportunity for achieving improved patient performance and increases the overall benefit

Acute myocardial infarction in patients admitted to c.c.u Arbil teaching hospital comparative study on risk factors and complications

A prospective study on patients admitted to ccu in Arbil teaching hospital was carried out over one year period from June 1988-June 1989, out of [246] patients admitted to the unit, 165 were found to have acute myocardial infarction. 105 [63%] were males, 60 [37%] were females, 102 [61%] had ventricular premature beat, 105 [63%] were smoker or had history of smoking, other risk factors observed less frequently. 76.8% of our patients were admitted after 4th from onset of their symptoms. 10 patients had primary ventricular fibrillation, [5] five were successfully resuscitated. 17 out of 21 patients with asystole died. Total mortality rate 25 of 165 patients was [15.15%]. Our results compared to other studies in other studies in other parts of our country