RESUMO
Exosome is a kind of functional vesicles secreted to the extracellular matrix .The role of glioma exosomes in the development , diagnosis and treatment of glioma is increasingly recognized .This review aims to summarize the most common biomarkers of glioma exosomes and the applications of exosomes in treatments , which mainly includes mediating immune therapy , anti-tumor therapeutic vehicles , and intervention of intercellular communications in tumor cells.
RESUMO
Neoplasms are well known to be a complication in cases of acromegaly,especially thyroid and colorectal neoplasia. The incidence and mortality of neoplastic complications in acromegaly patients are higher than that of the general population,the pathogenesis of which is correlated with elevated serum levels of insulin-like growth factor 1 (IGF-1) and activation of IGF-1 signaling pathway. Early screening and intervention of neoplastic complications play an important role in decreasing the mortality of acromegaly patients.
RESUMO
Neoplasms are well known to be a complication in cases of acromegaly,especially thyroid and colorectal neoplasia. The incidence and mortality of neoplastic complications in acromegaly patients are higher than that of the general population,the pathogenesis of which is correlated with elevated serum levels of insulin-like growth factor 1 (IGF-1) and activation of IGF-1 signaling pathway. Early screening and intervention of neoplastic complications play an important role in decreasing the mortality of acromegaly patients.