Clinical and laboratory characteristics of juvenile myelomonocytic leukemia / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the clinical and laboratory characteristics of juvenile myelomonocytic leukemia (JMML).</p><p><b>METHODS</b>The clinical characteristics and laboratory results were retrospectively analyzed in 10 children with newly diagnosed JMML. They were compared with those of 28 children with myelodysplastic syndrome (MDS) and 44 children with chronic myeloid leukemia (CML).</p><p><b>RESULTS</b>Compared with the children with CML or MDS, the children with JMML had significantly higher rates of skin rashes, ecchymosis, and lymphadenectasis, a significantly lower serum cholinesterase (ChE) level, and a significantly higher fetal hemoglobin level (P<0.05). The white blood cell count of children with JMML was significantly higher than that of children with MDS, but significantly lower than that of children with CML (P<0.05). In addition, the myeloid/erythroid ratio and rate of dyshaematopoiesis were significantly lower in children with JMML than those in children with CML or MDS. The children with JMML had a significantly higher expression of mature monocyte marker CD14 than those with CML or MDS (P<0.05). The levels of myeloid markers CD33, CD11b, CD13, and CD15 in children with JMML were significantly higher than those in children with MDS, but significantly lower than those in children with CML (P<0.05). The levels of CD2 and CD7 in children with JMML were higher than those in children with CML, but lower than those in children with MDS (P<0.05).</p><p><b>CONCLUSIONS</b>Skin rashes, ecchymosis, lymphadenectasis, and ChE reduction are more common in children with JMML than in those with CML or MDS, while dyshaematopoiesis is less common. In addition, CD14 level increases significantly in children with JMML.</p>

Population structure and seasonal dynamics of mosquitoes in different types of residential areas / 中国血吸虫病防治杂志

Objective To investigate the effect of the type of neighborhoods on the population structure and dynamics of mos-quitoes. Methods The adult population dynamics and larvae breeding of mosquitoes in four different types of neighborhoods were investigated in Yangzhou City. Results The number of trapped mosquitoes was the largest in the urban villages,and more than 800 adult mosquitoes were trapped in each urban village,which was significantly higher than that of ordinary and high qual-ity residences. Aedes albopictus and Culex pipiens pallens were dominant species(D>10％)in the four types of residential ar-eas,and Ae. albopictus was the most dominant species(D>57％). The peak occurrence of Ae. albopictus in different areas oc-curred in early June,and it occurred again in the urban village in the middle of September. The occurrence quantity of Cx. pipi-ens pallens was stable in the ordinary residence and high quality residence,while in the urban village and resettlement residen-tial area,the peak occurred in mid-October. The orders of positive rates,densities and the numbers of mosquitoes in the differ-ent types of residential areas were:the urban villages>the resettlement residence>the ordinary residence>the high quality resi-dence. The water vat had the highest positive rate in all kinds of larval habitats,followed by tires and green belt with garbage wa-ter. Conclusions The main mosquito species in the four different types of residential areas are all Ae. albopictus and Cx. pipiens pallens,but the positive rate,density and the number of mosquitoes in the different types significantly change,especially in the urban villages,the number and the occurrence peak are significant different from those in the other types of residential areas.