The minimal inhibitory concentration for sulbactam was not associated with the outcome of infections caused by carbapenem-resistant Acinetobacter sp. treated with ampicillin/sulbactam

OBJECTIVE: The objective of this study was to evaluate whether the outcomes of carbapenem-resistant Acinetobacter infections treated with ampicillin/sulbactam were associated with the in vitro susceptibility profiles. METHODS: Twenty-two infections were treated with ampicillin/sulbactam. The median treatment duration was 14 days (range: 3-19 days), and the median daily dose was 9 g (range: 1.5-12 g). The median time between Acinetobacter isolation and treatment was 4 days (range: 0-11 days). RESULTS: The sulbactam minimal inhibitory concentration (MIC) ranged from 2.0 to 32.0 mg/L, and the MIC was not associated with patient outcome, as 4 of 5 (80%) patients with a resistant infection (MIC≥16), 5 of 10 (50%) patients with intermediate isolates (MIC of 8) and only 1 of 7 (14%) patients with susceptible isolates (MIC ≤4) survived hospitalization. CONCLUSION: These findings highlight the need to improve the correlation between in vitro susceptibility tests and clinical outcome. .

Ocorrência de Listeria monocytogenes em Araraquara (AP) - Brasil / Occurence of Listeria monocytogenes in Araraquara (SP) - Brazil

Um total de 219 amostras de fezes humanas, 77 de material vaginal e 107 amostras de fezes de diversos animais foram analisadas quanto à presença de patógeno Listeria monocytogenes. Crioenriquecimento em caldo triptose, contendo 40 mg/L de ácido nalidíxico e isolamento em agar seletivo (agar BEA) foram utilizados para o processamento das amostras. Duas cepas isoladas de fezes humanas foram identificadas sorologicamente como L. monocytogenes soro tipo 1/2b e uma L. innoccua sorotipo 6B. L. monocytogenes não foi encontrada em material vaginal e fezes de animais. Apesar dos resultados desse estudo demonstrarem a baixa ocorrência de L. monocytogenes, a possibilidade de listeriose humana esporádica não deve ser descartada.