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Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-763562


Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment-refractory schizophrenic patients.

Antipsicóticos , Transtorno Bipolar , Clozapina , Dopamina , Eletroconvulsoterapia , Humanos , Recidiva , Esquizofrenia , Serotonina , Suicídio
Psychiatry Investigation ; : 581-587, 2019.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-760973


OBJECTIVE: This study examined the association between sleep habits and problems and Internet addiction in adolescents. METHODS: Junior high school students from a local town in Japan (n=853; male/female, 425/428) were the subjects of this study, and were assessed for severity of Internet addiction and sleep habits and problems using the self-reported version of the Young’s Internet Addiction Test (IAT) and Child and Adolescent Sleep Checklist (CASC). RESULTS: The wake time on weekdays was not significantly different among the three groups; addicted, possibly-addicted, and non-addicted. In the addicted group, the total night sleep time was significantly shorter, and the bedtime was significantly delayed on both weekdays and weekends compared with those in the possibly-addicted and non-addicted groups. The wake time of the addicted group was significantly later than that of the other groups. The total scores of sleep problems measured by the CASC were significantly higher in the addicted and possibly-addicted groups than in the non-addicted group. CONCLUSION: Internet addiction is strongly associated with sleep habits and problems in adolescents. These findings suggest that internet addiction should be considered while examining adolescent lifestyle.

Adolescente , Lista de Checagem , Criança , Humanos , Internet , Japão , Estilo de Vida , Smartphone
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-152983


OBJECTIVE: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil. METHODS: Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil. RESULTS: There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083). CONCLUSION: Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment.

Inibidores da Colinesterase , Transtornos Cognitivos , Demência , Humanos , Corpos de Lewy , Doença por Corpos de Lewy , Processamento Espacial , Percepção Visual
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-209617


Nasu-Hakola disease (NHD) is a rare autosomal recessive neuropsychiatric disorder characterized by bone cysts, fractures, and cognitive impairment. Two genes are responsible for the development of NHD; TYROBP and TREM2. Although it presents with typical signs and symptoms, diagnosing this disease remains difficult. This case report describes a male with NHD with no family or past history of bone fractures who was diagnosed using exome sequencing. His frontal lobe psychiatric symptoms recovered partially following treatment with sodium valproate, but not with an antipsychotic.

Cistos Ósseos , Consanguinidade , Exoma , Fraturas Ósseas , Lobo Frontal , Humanos , Masculino , Sódio , Ácido Valproico
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-55543


Clozapine is well-known for successful use in schizophrenic patients treatment resistant to other antipsychotics. However, even with clozapine, 25% of schizophrenic patients are not in remission. Recently, as adjunctive treatment with clozapine, electroconvulsive therapy has been reported to be an effective and safe adjunctive treatment. We report a Japanese schizophrenic woman who was not in remission with clozapine alone but with both clozapine and electroconvulsive therapy.

Antipsicóticos , Grupo com Ancestrais do Continente Asiático , Clozapina , Eletroconvulsoterapia , Feminino , Humanos , Lítio , Esquizofrenia
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-53114


Acute pancreatitis with antipsychotic treatment is rare but sometimes causes a fatal adverse effect. Most cases of acute pancreatitis due to atypical antipsychotic agents are reported to occur within six months of starting antipsychotic administration. Acute pancreatitis caused by risperidone is rare. The patient had a high fever, stomachache and vomiting. The results of the abdominal computed tomograhpy scan were negative. The results of the abdominal ultrasonography were positive for gallstones in gallbladder and distention of the common bile duct. She had been fasting and received antibiotic intravenous injections. Amylase and lipase titers were high. After risperidone discontinuation, both the levels of the amylase and the lipase were gradually decreased. Three months later, the patient still maintains a good clinical balance. Although atypical antipsychotic-induced pancreatitis has been reported in conjunction with hyperglycemia, the pathophysiologic mechanism of these adverse events remains unclear. This case got pancreatitis 6 month after risperidone treatment. Using the antipsychotic agents, it is necessary to monitor pancreas function.

Amilases , Antipsicóticos , Ducto Colédoco , Jejum , Febre , Vesícula Biliar , Cálculos Biliares , Humanos , Hiperglicemia , Injeções Intravenosas , Lipase , Pâncreas , Pancreatite , Risperidona , Esquizofrenia , Ultrassonografia , Vômito , Aripiprazol