Gastroplastia como medida terapêutica em pacientes obesos hipertensos / Gastroplastia as a therapeutic measure in obese hypertensive patients

A hipertensão arterial (HA) e a obesidade são doenças crônicas que se interrelacionam por meio de um quadro complexo de comunicação hormonal e uma série de cascatas enzimáticas. Isso faz com que o manejo dessas comorbidades seja complexo e multifatorial, muitas vezes levando a abandono ou falha terapêutica por parte de pacientes e profissionais de saúde, levando, então, às complicações dessas patologias. Há diversas formas de manejo e a gastroplastia, também conhecida como cirurgia bariátrica, é uma técnica cirúrgica que vem apresentando como alternativa satisfatória para o manejo terapêutico (AU).

Arterial hypertension (AH) and obesity are chronic diseases that are interrelated through a complex framework of hormonal communication and a series of enzymatic cascades. This makes the management of these comorbidities complex and multifactorial, often leading to treatment abandonment or failure by patients and health professionals, thus leading to complications of these pathologies. There are several forms of management and gastroplasty, also known as bariatric surgery, is a surgery that has been presented as a satisfactory alternative for therapeutic management (AU),

Asociación del polimorfismo rs2241766 del gen de la adiponectina y enfermedad arterial coronaria en individuos del sur de Chile / Association between single nucleotide polymorphism of adiponectin gene and coronary artery disease in Southern Chilean subjects

La adiponectina, hormona peptídica secretada por los adipocitos, actúa inhibiendo la formación de la placa ateromatosa en casi todas sus etapas, ya sea modulando la respuesta inflamatoria, inhibiendo la expresión de moléculas de adhesión, la activación de monocitos, la formación de células espumosas y la migración y proliferación de células de músculo liso. En el presente estudio, fue evaluada la frecuencia del polimorfismo 45TMJ (rs2241766) del gen que codifica para la hormona adiponectina (ADIPOQ), junto con su posible contribución al desarrollo de enfermedad coronaria en individuos del sur de Chile. Métodos: Fueron evaluados 416 individuos adultos (30 a 68 años); 200 casos confirmados por angiografía y 216 controles. La genotipificación del polimorfismo 451>G del gen ADIPOQ se realizó mediante la técnica de PCR-RFLP. Resultados: El análisis de los resultados demuestra que la presencia del alelo G del polimorfismo 45T>G del gen ADIPOQ duplica el riesgo de padecer enfermedad coronaria en la población estudiada (OR= 2.06; I.C.95 por ciento: 1.36-3.14). Conclusión: Nuestros datos revelaron la existencia de una interesante asociación entre el polimorfismo 45T>G del gen ADIPOQ y enfermedad arterial coronaria en los sujetos analizados. Es importante destacar, que este hallazgo constituye el primer antecedente en población chilena.

Background: Adiponectin, encoded by ADIPOQ gene, is a hormone secreted by adipocytes that acts inhibiting the atheromatous plaque formation, modulating the inflammatory response and inhibiting the expression of adhesion molecules with subsequent inhibition of adhesion and macrophage activation, foam cells formation and migration and proliferation of smooth muscle cells. Aim: to evaluate the possible association between the rs2241766 polymorphism of the ADIPOQ gene with coronary artery disease (CAD) in Southern Chilean subjects. Methods: We evaluated 416 unrelated individuals (38 -68 years old); 200 with CAD confirmed by angiography and 216 control individuals from Temuco city (Chile). The rs2241766 polymorphism (45T>G) of ADIPOQ gene was determined by PCR-RFLP. Results: CAD patients exhibited a high frequency of G allele when compared to controls (17 percent vs. 9 percent; p<0.001). The OR for CAD associated to G allele was 2.06 (95 percent CI: 1.36 - 3.14) confirming the association observed. Conclusion: Our data show that the rs2241766 ADIPOQ gene polymorphism contributed to CAD risk in the studied population.