RESUMO
BACKGROUND@#Even though there is bidirectional association between hypertension and atherosclerosis, atherosclerosis itself is involved in the process of endothelial repair. To clarify the association of endothelial repair with hypertension, a cross-sectional study was conducted.@*METHODS@#We conducted a cross-sectional study of 562 elderly Japanese men aged 60-69. As gamma-glutamyl transpeptidase (γ-GTP) could act as a marker of oxidative stress that injures endothelial cell and higher levels of CD34-positive cell indicate a higher activity of endothelial repair, we therefore performed a CD34-positive level specific analysis of γ-GTP on atherosclerosis and hypertension.@*RESULTS@#In the present study population, hypertension was independently and positively associated with atherosclerosis (multivariable odds ratio (OR) = 2.09 (1.30, 3.35)). Among participants with high CD34-positive cells, γ-GTP showed significant and positive association with atherosclerosis (OR of the log-transformed value of γ-GTP (OR) = 2.26 (1.32, 3.86)) but not with hypertension (OR = 0.77 (0.51, 1.17)). Among participants with low CD34-positive cells, even γ-GTP showed no significant association with atherosclerosis (OR = 0.92 (0.51, 1.68)), but was significantly and positively associated with hypertension (OR = 1.99 (1.27, 3.12)).@*CONCLUSIONS@#γ-GTP revealed to have ambivalent association with hypertension and atherosclerosis. Active endothelial repair that is associated with atherosclerosis might have beneficial association with hypertension.
RESUMO
The purpose of the present paper is to explore the relationships between the activity and fraction ratio of serum γ-GTP and the dietary intake of nutrients through three groups (lean, normal and overweight) by Broca's index. Broca's index in each groups was under 89 for the lean group, from 90to 109 for the normal group and over 110 for the overweight group. The subjects of study were 249 young healthy men except alcoholic.<BR>Results of the survey were as follows:<BR>1) There were statistically significant correlation between serum total γ-GTP activity in normal group and vitamin C intake (P<0.05).<BR>2) High negative correlations were observed between the fraction ratio of serum γ-GTP (1) and the vitamin B 1 intake (P<0.01), between the fraction ratio of serum γ-GTP (1) and vitamin C intake (P<0.01), and between the fraction ratio of serum γ-GTP (1) and the protein intake/kg of body weight (P<0.01) in the lean group. High negative correlations were observed between the fraction ratio of serum γ-GTP (1) and the protein intake (P<0.01), between the fraction ratio of serum y -GTP (1) and the vitamin B 1 intake (P<0.01), between the fraction ratio of serum γ-GTP (1) and vitamin C intake (P<0.01), and between the fraction ratio of serum γ-GTP (1) and the protein intake/kg of body weight (P<0.01) in the normal group. High negative correlation was observed between the fraction ratio of serum γ-GTP (1) and the vitamin C intake (P<0.01) in the overweight group.<BR>3) Multiple regression analysis showed that the variables which correlated best with the fraction ratio of serum γ-GTP (1) were dietary intakes of the energy, the vitamin C and the protein intake/kg of body weight in the lean group. The fraction ratio of serum γ-GTP (1) related to the vitamin C intake and the protein intake/kg of body weight in the normal group. In the overweight group, the fraction ratio of serum γ-GTP (1) related to the vitamin C intake and the animal protein intake.