125Iodine seed implantation and gamma knife for the treatment of portal vein tumor thrombosis in hepatocellular carcinoma：comparison of therapeutic efficacy / 介入放射学杂志

Objective To compare the therapeutic efficacy of 125Iodine seed implantation and gamma knife in treating portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC), and to discuss their clinical applications. Methods Between January 2009 and May 2013, a total of 60 HCC patients associated with PVTT were encountered at authors’ hospital. The patients were divided into gamma knife group (n=30) and 125Iodine seed group (n = 30). Gamma knife treatment was carried out for the patients of gamma knife group. A total of 3 - 10 target points were designed. Single dose of 3 - 6 Gy per fraction was used and 2 - 5 times radiotherapy every week were conducted. The total treatment dose was 30 - 50 Gy. In designing the therapeutic scheme, 50%-70%of iso-dose curve contained PTV. 125Iodine seed implantation was performed for the patients of 125Iodine seed group. After the treatment, the change of PVTT size was assessed. The clinical efficacy was evaluated. Results Three months after the treatment, in gamma knife group complete remission (CR) was seen in 0 patient (0%), partial remission (PR) in 8 patient (26.6%), stable disease (SD) in 17 patients (56.7%) and progressive disease (PD) in 5 patients (16.7%). In 125Iodine seed group, CR was obtained in 3 patients (10.0%), PR in 19 patients (63.4%), SD in 7 patients (23.3%) and PD in one patient (3.3%). Statistically significant differences in responding the therapy existed between the two groups (P < 0.05), although no significant difference in the improvement of ascites and hepatic function existed between the two groups (P<0.05). Conclusion For the treatment of portal vein tumor thrombosis of hepatocellular carcinoma, the short-term efficacy of 125Iodine seed implantation is much better than that of gamma knife, although its long-term effect needs to be further studied.

Different Implantation Way of ~(125)I Seeds Stent in the Treatment of Unresectable Esophageal Cancer / 医学研究杂志

0.05)in group B.Conclusions The method of intraluminal irradiation ~(125)I seeds stent in the treatment of unresectable esophageal cancer is effective.No significant difference was found between two implantation ways of ~(125)I seeds.Implantation with a distance of 1cm between the layers of ~(125)I seeds stent was more helpful to decreased relapes of malignant esophageal obstruction.

Prospective trial of self-expandable stent and/or Iodine-125 seeds on late stage esophageal cancer / 中华消化内镜杂志

0. 05). The mean survival time in Iodine-125 stent group was 10. 5 months prominently longer than those in group A 4. 4 months (P