Effects of 20% Aluminum Chloride in Axillary Hyperhidrosis not Accompanying Osmidrosis

OBJECTIVE: Surgical treatment of focal axillary hyperhidrosis is often unsatisfactory because of compensatory hyperhidrosis. The purpose of this study is to evalute the effect of decreased sweating production using 20% aluminum chloride on axillary hyperhidrosis. METHODS: From February to December, 2002, 10 patients(mean age 25.2 male 2, female 8) with clinical diagnosis of axillary hyperhidrosis were treated by 20% aluminum chloride solution. Until the desired degree of symptom relief was obtained, they were educated to apply every day and thereafter, the agent would be applied as often as is necessary. We analyzed patient's satisfaction and application time at onset of desired dryness, application interval to maintain the relief of symptom and side effects. RESULTS: Aluminum chloride solution was effective in treatment of axillary hyperhidrosis showing excellent result in 60% of patients and good in 40%. Application time at onset of desired dryness ranged from 1 to 6 days(mean 3 days). Application interval to maintain the relief of symptom ranged from 5 to 45 days(mean 12 days). There were no significant complications but just mild irritation and miliaria in seven patients. CONCLUSION: 20% aluminum chloride solution is the simple, safe and less expensive method for initial treatment for axillary hyperhidrosis not accompanying osmidrosis.

Clinical Analysis on the Therapeutic Efficacy of 20% Aluminum Chloride Solution in Primary Hyperhidrosis / 대한피부과학회지

BACKGROUND: A large number of therapeutic options are used for the treatment of primary hyperhidrosis. These include application of topical agents, iontophoresis, sympathectomy and recently botulium toxin injection. But, It should be desirable as first treatment to choice a simple, safe, and less expensive method that also proved to be effective. OBJECTIVE: The aim of this study was to clinically prove 20% aluminum chloride solution to deserve to be the initial choice of treatment modality for primary hyperhidrosis. METHODS: A total of 22 patients(mean age 24.1, male 3, female 19) with clinical diagnosis of primary hyperhidrosis were treated by 20% aluminum chloride solution. Until the desired degree of dryness was obtained, they were educated to apply everyday and thereafter, the agent would be applided as often as is necessary. By regular meeting including telephone interview, we analyzed patient satisfaction and other clinical parameters such as application time at onset of desired dryness, applicaton interval to maintain the relief of symptoms, and side effects during various follow-up periods. RESULT: Aluminum chloride solution was effective not only in axillary hyperhidrosis but also in palmoplantar hyperhidrosis(patient satisfaction, axillae:excellent, 12 of 16(75%); good, 4(25%), palms or soles:excellent, 3 of 6(50%); good, 2(33%)). Applicaton interval to maintain the relief of symptoms ranged from 5 to 60 days with mean 10 days. There were no significant complications(mild irritation 50%). CONCLUSION: Aluminum chloride solwtion is the simplest, safest and least expensive method for initial treatment of primary hyperhidrosis. And its effect could be maintainable for a relatively long-term period.

Efficacy of a 20% Aluminum Chloride in Alcohol Solution in the Treatment of Hyperhidrosis: A Study Using a Hydrometer

BACKGROUND: Excessive sweating, especially of the palms, soles and axillae, is a socially and an occupationally distressing, and sometimes disabling condition. A variety of treatment methods are used to reduce profuse sweating including topical agents, iontophoresis and symphatectomy. OBJECTIVE: We investigated whether a 20% aluminum chloride solution is efficient in the treatment of axillary and palmoplantar hyperhidrosis using a skin surface hydrometer. METHODS: We treated 31 patients (7; male, 24; female) by Drysol once a day at bedtime for four weeks. We had measured the conductances on the stratum corneum of the palms, soles and axillae using a skin surface hydrometer before and after treatment every week for four week RESULTS: There was a reduction of conductances after the treatment by Drysol (p<0.05). The reduction of conductances was continued for four weeks (p<0.05). CONCLUSION: Drysol is an efficient, safe, and simple method for initial treatment of the primary hyperhidrosis.