A new cucurbitane triterpene in acid-treated ethanol extract from Momordica charantia / 中草药·英文版

Objective: To study the chemical constituents in the acid-hydrolyzed ethanol extract from Momordica charantia. Methods: The ethanol extract from M. charantia was hydrolyzed by 36% HCl and the hydrolysate was isolated by silica gel column chromatography and preparative HPLC. The structures of the isolated compounds were identified by spectral analyses, physical constants, and chemical evidences. Results: Two cucurbitane triterpenoids were isolated and identified as 5β,19-epoxy-cucurbita-6,22. E,24-trien-3β-ol (1) and cucurbita-6,22(E),24-trien-3β-ol-19,5β-olide (2). Conclusion: Compound 1 is a new compound. © 2013 Tianjin Press of Chinese Herbal Medicines.