Research progress of microRNA-214 in the cervical cancer / 医学研究生学报

MicroRNAs ( miRNAs ) play important roles in the processes of the occurrence and development of cancers , through regulating tumor related gene expression at post-transcription.It has shown that the expression of miR-214 is aberrant in cervi-cal cancer.Also,miR-214 could affect the proliferation, migration, invasion and apoptosis of tumor cells by targeting various genes . This article focuses on the studies of miR-214 function in cervical cancer , and will provide a novel approach for the clinical diagnosis and the treatment of cervical cancer .

Research progress of a new oncotherapy target TRAP1 / 中国药理学通报

Tumor necrosis factor receptor-associated protein 1 (TRAP1),as one of the main members of the heat shock protein 90 family, resists oxidative stress-induced apoptosis as well as predominantly maintains the integrity of mitochondria and cellu-lar homeostasis. Abnormal expression of TRAP1 was herein closely related to the onset and progression of a wide variety of tumors. As a key regulatory factor mediating energy metabolism within tumor cells, TRAP1 may be able to kill them by interfer-ing with such metabolism. More importantly, the abnormal ex-pression of TRAP1 played a less important role in normal cells, allowing TRAP1 to be a particularly attractive target as it can be used in tumor treatment or interference. The relationship be-tween abnormal expression of TRAP1 protein and tumor onset was reviewed. Besides, the mechanism by which disordered TRAP1 protein expression induced tumor formation was postula-ted, which may provide references for future research and clini-cal treatment.

Advances on abnormal expression of E-cadherin with bronchial asthma / 中国药理学通报

Bronchial asthma is a kind of respiratory disease which affects people 's life quality seriously. Many factors in-volved in the occurrence and development of such disease, of which the aberrant expression of E-cad plays a critical role in it. Research found that E-cad is an important cell adhesion molecu-lar, and its main function is to maintain the structural integrity of cells and participate in the improvement of airway remodeling as well as restoration of immune function. Further study showed that the role of mucosal barrier of airway epithelial cells in bronchial asthma patients was often damaged. Moreover, the protein ex-pression of E-cad decreased significantly in mucosal molecular, which suggested that the abnormal expression of E-cad was in-volved in the development of bronchial asthma. A review on the relations between the abnormal expression of E-cad protein and bronchial asthma has been discussed in this paper, also it in-cludes the discussion about the mechanisms of E-cad’ s disorder-induced bronchial asthma as well as explores the strategies of bronchial asthma treatment, which may provide references for the follow-up research and clinical treatment.

Research progress on ion channels in human glioma / 肿瘤研究与临床

Glioma is a serious threat to human health.Increasing evidences indicate that abnormal expression and activities of a number of ion channels,e.g.voltage-gated K+,Ca2+,C1-channels,are involved in the growth,proliferation,migration and invasion of glioma cells.Ion channels may affect the occurrence and development of glioma cells through regulating the membrane potential,adjusting the cytoplasmic volume,ion concentration,and pH value.In-depth understanding the role of ion channels in formation,development and transfer process of glioma may provide new targets for glioma prevention and treatment.In this paper,the advanced studies of ion channels in glioma were briefly reviewed.

The research progression on the relationship between TRPS1 and tumors / 实用肿瘤学杂志

Tricho-rhinophalangeal syndrome -1 gene(TRPS1),a new GATA family member,is highly prevalent in many tissues .It plays an important role in the regulation of cell proliferation and tissue development . The genetic missing of TRPS1 may lead to Tricho-rhinophalangeal syndrome .In recent years,studies have dem-onstrated that TRPS1 abnormal expression exists in a variety of tumors , and is associated with carcinogenesis , lymph node metastasis,pathological grading and clinical staging .Therefore,TRPS1 is considered as a potential tumor suppressor gene ,its overexpression may be one of mechanisms for carcinogenesis and progression of cancer . This review focuses on the role of TRPS 1 gene in carcinogenesis and progression of carcinoma ,and further to pro-vide a new biomarker for predicting cancer prognosis and therapy .

The relationship between EphB receptor and the development of tumor / 实用肿瘤学杂志

Currently ,EphB receptor has been demonstrated as an important factor on the biological be -havior of normal cells .Some studies found that it plays an important role in the regulation of normal cell morpholo -gy,cell adhesion ,migration and angiogenesis .There is a certain relationship between abnormal expression of EphB receptor with a variety of tumor development .Visiblely,EphB receptor is important research direction in cancer studies,understanding the relationship between EphB receptor and tumor can better realize the progress of the tumor,and further to provide more scientific basis for cancer treatment and prevention .

Advances on LKB1 in the study of lung cancer / 中国癌症杂志

Recent studies have shown that the loss-of-function LKB1 mutations occur in approximately 30% of human non-small cell lung cancer(NSCLC). Studies from lung cancer animal models have demonstrated that functional loss of LKB1 dramatically promotes lung cancer invasion and progression, underscoring the essential role of LKB1 as a potent tumor suppressor involved in lung cancerigenesis, differentiation and metastasis. However, the relationship between loss-of-function LKB1 mutations and lung cancer prognosis remain largely unclear, therefore, we summarized the progress of the research on LKB1.