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1.
Rev. Soc. Bras. Med. Trop ; 52: e20180348, 2019.
Artigo em Inglês | LILACS | ID: biblio-1013316

RESUMO

Abstract We report the occurrence in Brazil of the bla NDM-1 gene in Acinetobacter pittii, prior to the previously described first reports regarding the species Providencia rettgeri and Enterobacter hormaechei. Clinical isolates were investigated by polymerase chain reaction followed by bidirectional sequencing, and species was confirmed by 16S rDNA sequencing and matrix-assisted laser desorption-ionization time-of-flight spectrometry. A. pittii carrying bla NDM-1 was confirmed in a patient with no national or international travel history, or transfer from another hospital. The findings warn of the possibility of silent spread of bla NDM-1 to the community.


Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Acinetobacter/isolamento & purificação , beta-Lactamases/isolamento & purificação , Infecções por Acinetobacter/microbiologia , Antibacterianos/uso terapêutico , beta-Lactamases/genética , Brasil , Infecções por Acinetobacter/tratamento farmacológico , Testes de Sensibilidade Microbiana
2.
Mem. Inst. Oswaldo Cruz ; 112(10): 723-727, Oct. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1040561

RESUMO

The development of carbapenem-resistant Acinetobacter species is of serious concern in the hospital settings and naturally occurring oxacillinase genes (blaOXA) have been identified in several Acinetobacter species. In this study, we report the genome sequence of A. pittii TCM178 belongs to ST950, a multidrug-resistant isolate that harbored the blaOXA-72 and blaOXA-533 genes simultaneous. The genome size was estimated to be 3,789,564 bp with 3,501 predicted coding regions, and G+C content is 37.60%. Our findings have raised awareness of the possible constitution of a reservoir for peculiar carbapenemase genes in A. pittii that may spread among other Acinetobacter species in China.


Assuntos
Humanos , Proteínas de Bactérias/genética , Acinetobacter/efeitos dos fármacos , Acinetobacter/enzimologia , beta-Lactamases/genética , Genoma Bacteriano/genética , Farmacorresistência Bacteriana Múltipla/genética , Acinetobacter/classificação , Sequência de Bases , China , Análise de Sequência de DNA
3.
Braz. j. microbiol ; 48(2): 196-197, April.-June 2017.
Artigo em Inglês | LILACS | ID: biblio-839366

RESUMO

Abstract Worldwide increasing emergence of carbapenem-resistant Acinetobacter spp. has rendered the limited availability of effective antimicrobial agents and has become a major public health concern. In this study, we report the draft genome sequence of A. pittii TCM156, a multidrug-resistant isolate that harbored the blaOXA-357 gene. The genome sequence was further analyzed by various bioinformatics methods. The genome size was estimated to be 3,807,313 bp with 3508 predicted coding regions and G + C content is 38.7%. These findings have raised awareness of the possible emergence of OXA-type enzyme-producing A. pittii isolate in China.


Assuntos
Acinetobacter/genética , beta-Lactamases/metabolismo , Infecções por Acinetobacter/microbiologia , DNA Bacteriano/química , Genoma Bacteriano , Análise de Sequência de DNA , Farmacorresistência Bacteriana Múltipla , Composição de Bases , Acinetobacter/isolamento & purificação , Acinetobacter/efeitos dos fármacos , Acinetobacter/enzimologia , DNA Bacteriano/genética , China
4.
Mem. Inst. Oswaldo Cruz ; 111(9): 592-593, Sept. 2016.
Artigo em Inglês | LILACS | ID: lil-794730

RESUMO

Acinetobacter pittii has emerged as an important hospital pathogen that is associated with outbreaks and drug resistance. In cystic fibrosis (CF) patients, the detection of Acinetobacter spp. is rare; however, we isolated the A. pittii sequence type ST643 in several Brazilian CF patients treated in the same centre. The current study describes the draft genome of A. pittii ST643.


Assuntos
Humanos , Infecções por Acinetobacter/microbiologia , Acinetobacter/genética , Fibrose Cística/microbiologia , Acinetobacter/classificação , DNA Bacteriano/genética , Genoma Bacteriano , Tipagem de Sequências Multilocus , Reação em Cadeia da Polimerase
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