Dyslipidemia and dysglycemia in patients with HIV infection and in patients on antiretroviral therapy.

Objective: Use of ART in HIV infected individuals’ results in reduced mortality and morbidity associated with AIDS. Long term complications of HIV & ART including dyslipidemia & dysglycemia have raise concern regarding accelerated cardiovascular risk in these patients. Aim of study is to determine prevalence of dyslipidemia & dysglycemia in HIV infected patients and its relation to CD 4 count. Material and Methods: A cross sectional two arm comparison study carried out at Shree Sayajirao General Hospital and Medical College Baroda. The treatment arm, ON ART arm, constituted 30 patients already on ART defined as a combination of at least three classes of antiretroviral drugs, namely PIs, NNRTIs and NRTIs, one of which was a PI or an NNRTI ,or a triple combination of NRTIs. Comparator arm, ART naïve arm constituted 30 HIV-positive patients, eligible for, but not yet receiving ART. Dyslipidemia & dysglycemia were defined as high total or LDL cholesterol, high triglycerides, or low HDL cholesterol according to the adult treatment panel III (ATP III) guidelines and as the presence of diabetes , impaired fasting blood sugar(FBS) , impaired post prandial blood sugar(PP2BS) or impaired glucose tolerance according to ADA (American diabetes association)criteria ,respectively. Discussion: Dysglycemia was present in 30% of study population and dyslipidemia was present in 73.33% of study population. Difference in elevation of serum Cholesterol level and serum LDL level in patients on ART arm was statistically significant. Dysglycemia and dyslipidemia was associated with low CD 4 count compare to patients with normal blood glucose level and normal lipid profile level.

Unusual retinal manifestations of PORN combined complications of central retinal artery and vein occlusions / 国际眼科杂志(Guoji Yanke Zazhi)

·AIM:To describe an unusual combination of retinal manifestations in an AIDS patient with progressive outer retinal necrosis (PORN),complicated by combined central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO).·METHODS:A case report.·RESULTS:The patient presented with PORN with primary optic nerve involvement complicated by combined central retinal artery occlusion(CRAO) and central retinal vein occlusion(CRVO) as a primary manifestation of Varicella Zoster Virus (VZV).Aggressive treatment with intravitreal and specific systemic anti-VZV therapy,in addition to systemic highly active antiretroviral therapy (HAART) achieved retinal quiescence with sparing of the fellow eye.Visual outcome of the affected eye was poor.·CONCLUSION:We present the first report of PORN associated with the unusual combined complications of CRAO and CRVO. Aggressive local treatment was combined with systemic therapy,which achieved local control and empirical prophylaxis for the fellow eye.

Analysis on the Traditional Chinese Medicine Syndromes of 177 HIV/AIDS P atients / 中医杂志

Objective To study the rule of distribution and evol vement of TCM syn dromes in HIV/AIDS patients. Methods Totally 177 HIV/AI DS patients were investigated with questionnaire in the epide miological study to collect the data of diagnosis, and the rou tine test of CD4+T lymphocyte count was carried out. Results The young and mid dle-aged females were the most involved group with an increasing incidence in G u angdong Province and with a strong relation of sex and infection route. The main symptoms of the 177 HIV/AIDS patients were fatigue, cough and loss of appetite, the secondary ones were night sweating, skin itching, headache, and hair loss, and the most common sign was skin rash. The leading TCM syndromes were qi and yi n deficiency and lung and kidney deficiency. The distribution of symptoms and si gns, syndromes and various indices was significantly different in gender, age an d infection route (P