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1.
Clinical Psychopharmacology and Neuroscience ; : 377-387, 2019.
Artigo | WPRIM | ID: wpr-763555

RESUMO

OBJECTIVE: Based on the constant associations made between major depressive disorder (MDD) and alpha asymmetry, and MDD and suicide, this study aimed to examine the relationship between frontal alpha asymmetry and suicide in MDD patients. METHODS: Sixty-six MDD patients, of whom fifteen were male and fifty-one were female, were recruited. Independent groups were created based on the median score of frontal alpha asymmetry: the left dominant (LD) group and the right dominant (RD) group. The alpha band (8–12 Hz) and its sub-bands (i.e., low alpha band: 8–10 Hz; high alpha band: 10–12 Hz) were of interest. Source level alpha asymmetry was calculated as well. RESULTS: Suicidal behavior was positively correlated with the asymmetry indices of the low alpha band and the alpha band in the LD group and that of the high alpha band in the RD group. Source level analysis revealed positive correlations between suicidal behavior and the asymmetry index of the low alpha band in the LD group. CONCLUSION: Frontal alpha asymmetry, especially that of the low alpha band, might reflect the cognitive deficits associated with suicidal behaviors in MDD patients.


Assuntos
Feminino , Humanos , Masculino , Transtornos Cognitivos , Depressão , Transtorno Depressivo Maior , Eletroencefalografia , Suicídio
2.
Psychiatry Investigation ; : 1168-1173, 2018.
Artigo em Inglês | WPRIM | ID: wpr-719188

RESUMO

OBJECTIVE: After the Sewol ferry disaster, bereavement with suicidal ideation was a critical mental health problem that was accompanied by various neuropsychological symptoms. This study examined the frontal alpha asymmetry (FAA), heart rate variability (HRV), and several psychological symptoms in bereaved family members (BFM) after the Sewol ferry disaster. METHODS: Eighty-three BFM after the Sewol ferry disaster were recruited. We assessed FAA, HRV, and psychological symptoms, including depression, post-traumatic stress, post-traumatic growth factor, anxiety, grief, and positive resources, between BFM with the presence and absence of current suicidal ideation. RESULTS: Compared to BFM without suicidal ideation, BFM with suicidal ideation showed a higher FAA with right dominance. Significant differences in psychological symptoms were observed between the groups. In BFM with suicidal ideation, the low: high frequency (LF:HF) ratio correlated with social resources and support. CONCLUSION: The FAA and LF:HF ratio may be biomarkers that represent the pathological conditions of BFM with suicidal ideation. If researched further, they may shed light on the interaction between bereavement with suicidal ideation and social resources for therapeutic intervention.


Assuntos
Humanos , Ansiedade , Luto , Biomarcadores , Depressão , Desastres , Pesar , Frequência Cardíaca , Coração , Saúde Mental , Ideação Suicida
3.
Braz. j. med. biol. res ; 43(6): 585-592, June 2010. ilus, tab
Artigo em Inglês | LILACS | ID: lil-548274

RESUMO

The effect of physical exercise on the treatment of depressive elderly adults has not been investigated thus far in terms of changes in cortical hemispheric activity. The objective of the present study was to identify changes in depressive symptoms, quality of life, and cortical asymmetry produced by aerobic activity. Elderly subjects with a diagnosis of major depressive disorder (DSM-IV) were included. Twenty patients (70 percent females, 71 ± 3 years) were divided into an exercise group (pharmacological treatment plus aerobic training) and a control group (undergoing pharmacological treatment) in a quasi-experimental design. Pharmacological treatment was maintained stable throughout the study (antidepressants and anxiolytics). Subjects were evaluated by depression scales (Beck Depression Inventory, Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and the Short Form Health Survey-36, and electroencephalographic measurements (frontal and parietal alpha asymmetry) before and after 1 year of treatment. After 1 year, the control group showed a decrease in cortical activity on the right hemisphere (increase of alpha power), which was not observed in the exercise group. The exercise group showed a significant decrease of depressive symptoms, which was not observed in the control group. This result was also accompanied by improved treatment response and remission rate after 1 year of aerobic exercise associated with treatment. This study provides support for the effect of aerobic training on alpha activity and on depressive symptoms in elderly patients. Exercise facilitates the treatment of depressive elderly adults, leading to clinical and physical improvement and protecting against a decrease in cortical activity.


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ritmo alfa , Transtorno Depressivo Maior/terapia , Terapia por Exercício/métodos , Qualidade de Vida , Ansiolíticos/uso terapêutico , Antidepressivos/uso terapêutico , Terapia Combinada , Transtorno Depressivo Maior/psicologia , Eletroencefalografia , Seguimentos , Escalas de Graduação Psiquiátrica
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