Resultados de la aplicación del consenso cubano de prevención del cáncer anal / Results of the Application of the Cuban Consensus for Anal Cancer Prevention

Introducción: El incremento del cáncer anal en poblaciones de alto riesgo induce a la implementación de protocolos para efectuar diagnóstico precoz y seguimiento de neoplasia anal intraepitelial. Objetivo: Evaluar los resultados de la aplicación del consenso nacional de prevención del cáncer anal en Cuba. Métodos: Se realizó un estudio longitudinal prospectivo con 43 pacientes de alto riesgo de neoplasia anal intraepitelial atendidos en la consulta de Coloproctología del Hospital Universitario Clínico Quirúrgico "Comandante Manuel Fajardo", desde 2018 hasta 2019. Se evaluaron en el momento del diagnóstico y a los 6 meses. Se hicieron estudios de citología anal (normales, lesiones de bajo y alto grado, y células epidermoides atípicas de significado incierto), examen digital anorrectal y anoscopia de alta resolución (normal, tipos I-II y III). Resultados: El 53,5 por ciento de los resultados fueron normales. En los hallazgos anormales por citología anal, la lesión de bajo grado fue la de mayor porcentaje (50 por ciento). La neoplasia anal intraepitelial tipo I fue la de mayor frecuencia (52,9 por ciento). De los pacientes evolucionados a los 6 meses, la mayoría tuvo resultados anormales de citología anal (55,6 por ciento), se presentó el 70 por ciento con lesiones de bajo grado. El examen digital anorrectal fue normal en todos los casos. Los factores de riesgos predominantes fueron: sexo con penetración anal y sexo de hombres con otros hombres, incluyendo que todos habían padecido el virus del papiloma humano. Conclusiones: El protocolo permitió identificar fundamentalmente lesiones de bajo grado. Los factores de riesgo influyen en la aparición de esta neoplasia(AU)

Introduction: The increase of anal cancer in high-risk populations leads to the implementation of protocols to perform early diagnosis and follow-up of anal intraepithelial neoplasia. Objective: To evaluate the results of the application of the national consensus for anal cancer prevention in Cuba. Methods: A prospective longitudinal study was conducted with 43 patients at high risk of intraepithelial anal neoplasia cared for in the coloproctology consultation at Comandante Manuel Fajardo Clinical Surgical University Hospital, from 2018 to 2019. They were evaluated at the time of diagnosis and at six months. Anal cytology studies (normal, low- and high-degree lesions, and atypical epidermoid cells of uncertain significance), anorectal digital examination and high resolution anoscopy (normal, types I-II and III) were performed. Results: 53.5 percent of the results were normal. In abnormal anal cytology findings, low-degree lesion had the highest percentage (50 percent). Anal intraepithelial neoplasia type I was the most frequent (52.9 percent). Of the patients followed up at six months, the majority had abnormal anal cytology results (55.6 percent); 70 percent had low-degree lesions. The anorectal digital examination was normal in all cases. The predominant risk factors were anal penetrative sex and male-to-male sex, including that all had had human papillomavirus. Conclusions: The protocol allowed the identification of primarily low-degree lesions. Risk factors influence the appearance of this neoplasm(AU)

Experiencia en cirugía de condilomas anales en mayores de 15 años / Experience in anal condyloma surgery in patients older than 15 years

Resumen Objetivo: Describir la experiencia en cirugía electiva de condilomas anales en pacientes mayores de 15 años en un hospital terciario de la Región Metropolitana. Material y Método: Estudio observacional retrospectivo y descriptivo, en el cual se analizan las intervenciones quirúrgicas electivas realizadas entre 2008 a 2021. Resultados: Dentro del período analizado se obtuvo 165 cirugías de condilomas anales, lo que corresponde a 137 pacientes en total. El 85% de los pacientes son de sexo masculino, el 68% de los pacientes son VIH positivo, un 87% de los pacientes MSM (hombres que tienen sexo con otros hombres) son VIH positivo, el 34% de los pacientes tiene antecedente de ETS, el 46% de los pacientes recibió terapia tópica como tratamiento preoperatorio o posoperatorio. Un 25% de los pacientes presenta recidiva en su historia personal, un 21% de los pacientes presenta lesiones anales intraepiteliales de alto grado, un 6% presenta carcinoma escamoso infiltrante. No hubo mortalidad descrita. Discusión: El presente estudio, describe la experiencia en cirugía de condilomas de un hospital terciario de la Región Metropolitana de Chile, cuya población corresponde a un estrato socioeconómico medio y bajo. Se logra describir a la población que es intervenida de condilomas acuminados, además de sus resultados quirúrgicos precoces y a largo plazo. Conclusión: El presente estudio, presenta una población de 137 pacientes operados de condilomas anales, a partir de los hallazgos de la cirugía. Se cumple el objetivo del estudio de caracterizar en un período de 12 años los resultados quirúrgicos de dicha serie, algo no reportado previamente en la literatura chilena.

Objective: To describe the experience in elective surgery for anal condylomas in patients over 15 years of age in a tertiary hospital in the Metropolitan Region. Materials and Method: Retrospective and descriptive observational study about elective surgical interventions performed between 2008 to 2021. Results: Within the analyzed period, 165 anal warts surgeries were obtained, corresponding to 137 patients. 85% of the patients are male, 68% are HIV positive, 87% of the MSM patients are HIV positive, 34% of the patients have a history of STDs, 46% of the patients received topical therapy as preoperative or postoperative treatment. 25% present recurrence in their personal history, 21% present high-grade anal intraepithelial lesions, 6% present infiltrating squamous carcinoma. There was no reported mortality. Discussion: The present study describes the experience in condyloma surgery in a tertiary hospital in the Metropolitan Region of Chile, whose population corresponds to a medium and low socioeconomic stratum. It is possible to describe the population that undergoes surgery for this reason, in addition to its early and long-term surgical results. Conclusion: The present study presents a population of 137 patients operated on for anal condylomas, based on the findings of the surgery. The objective of the study to characterize the surgical results of this series over a 12-year period is fulfilled, something not previously reported in the Chilean literature.

Enfermedad de Paget extramamaria perianal, tratada con imiquimod tópico / Atypical presentation of perianal extramammary Paget's disease, treated with topical imiquimod

RESUMEN La enfermedad de Paget extramamaria (EPEM) perianal es un adenocarcinoma intraepitelial del margen anal de muy baja frecuencia. La forma primaria representa una neoplasia de origen apocrino, mientras que la forma secundaria representa una diseminación pagetoide de una neoplasia maligna en general anorectal. Debido a su similitud clínica con otras patologías de presentación frecuente, se requiere de un alto índice de sospecha para diagnosticarla. La resección quirúrgica amplia o la cirugía micrográfica de Mohs se considera comúnmente el pilar del tratamiento con altas tasas de recurrencia. Estudios previos han demostrado buena respuesta en la EPEM vulvar con imiquimod 5% en crema, pero su eficacia no ha sido bien descrita en la afectación perianal. En este artículo presentamos un caso de EPEM perianal primario con sobreinfección con HPV, al que se le indicó tratamiento tópico con imiquimod.

ABSTRACT Perianal extramammary Paget disease is a very low frequency intraepithelial adenocarcinoma of the anal margin. The primary form represents a neoplasm of apocrine origin, while the secondary form represents a pagetoid spread of a generally anorectal malignant neoplasm. Due to its clinical similarity with other pathologies with frequent presentation, a high index of suspicion is required to diagnose it. Wide surgical resection or Mohs micrographic surgery is commonly considered the mainstay of treatment with high recurrence rates. Previous studies have shown a good response in vulvar extramammary Paget disease with imiquimod 5% cream, but its efficacy has not been well described in perianal involvement. In this article we present a case of primary perianal extramammary Paget disease with HPV superinfection, which received topical treatment with imiquimod.

Anal intraepithelial neoplasia associated with high-grade vulva injury (usual-type vulvar intraepithelial neoplasia): surgical treatment with cutaneous flap advancement

The aim of the present article is to report the case of a young patient with bowenoid papulosis who was a carrier of other sexually-transmitted infections (STIs), such as HIV and high-grade vulva lesion (usual-type vulvar intraepithelial neoplasia, VIN), and to demonstrate the strategy used to manage the case, as well as to discuss important issues regarding the standardization of intraepithelial lesions. (AU)

High-risk human papillomavirus infection and associated factors in the anal canal of HIV-positive patients in Medellín, 2017-2018 / Infección por el virus del papiloma humano de alto riesgo y factores asociados en canal anal de pacientes con VIH en Medellín, 2017-2018

ABSTRACT OBJECTIVE To estimate the prevalence of high-risk human papillomavirus (HR-HPV) anal infection and associated factors in human immunodeficiency virus (HIV) positive patients in Medellín. METHODS Descriptive cross-sectional study in 300 HIV-positive patients, adults, with history of anal intercourse, treated in two health care services of Medellín 2017-2018. We conducted a structured survey on sociodemographics, sexual behavior and medical history. HPV was detected in anal swabs tested by the COBAS 4800 system. Exploratory data analysis of risk factors associated with HR-HPV was conducted by chi-square test of independence and both raw and adjusted prevalence ratios used the Poisson regression model, at a 95% confidence interval. RESULTS The high-risk HPV had a prevalence of 82.7%; HPV16 had a prevalence of 32.7%, HPV18 a prevalence of 21.7% and other HPV types scored 78.3%. The high-risk HPV prevalence in women was of 68.2% and 83.8% in men. The risk factors associated with high-risk HPV after adjustment were age under 30 years, elementary education, casual sex partners, and first sexual activity before 18 years old. CONCLUSIONS The high incidence of high-risk HPV, along with the occurrence of coinfections by multiple types in the study population shows their susceptibility to develop some type of anal intra-epithelial neoplasia. It is important to establish sexual health programs focused on primary health care.

RESUMEN OBJETIVO Estimar la prevalencia de la infección anal por el virus del papiloma humano de alto riesgo y factores asociados en pacientes con el virus de inmunodeficiencia humana (VIH) de Medellín. MÉTODOS Estudio descriptivo transversal en 300 pacientes VIH positivos, adultos, con historia de relaciones sexuales anales, atendidos en dos instituciones de salud de Medellín 2017-2018. Se aplicó una encuesta estructurada sobre características socio-demográficas, comportamiento sexual y antecedentes clínicos. El VPH se detectó en muestras de exfoliado anal mediante la prueba COBAS 4800. Se realizó análisis exploratorio de factores de riesgo asociados al VPH-AR mediante la prueba Chi cuadrado de independencia y razones de prevalencia cruda y ajustadas por regresión de Poisson, con intervalos del 95%.de confianza. RESULTADOS La prevalencia global de VPHAR fue 82,7%; VPH 16 de 32,7%, VPH 18 de 21,7% y otros tipos 78,3%. La prevalencia de VPHAR en mujeres fue de 68,2% y en hombres, 83,8%. Los factores de riesgo asociados al VPH-AR luego del ajuste fueron tener menos de 30 años, algún grado de educación básica primaria, pareja ocasional e inicio de relaciones sexuales antes de 18 años. CONCLUSIONES La alta frecuencia de infección por VPHAR, así como la existencia de co-infecciones por múltiples tipos en la población de estudio muestra la susceptibilidad que tienen para desarrollar algún grado de Neoplasia Intraepitelial Anal. Es importante establecer programas de promoción de la salud sexual con enfoque de atención primaria.

Profile of women with anal neoplasia associated with cervical neoplasia receiving care at a tertiary healthcare facility in northeastern Brazil / Perfil de mulheres com neoplasia anal associada à neoplasia cervical atendidas em um serviço de saúde terciário do nordeste do Brasil

Abstract Objective: To describe the epidemiological, clinical and laboratory profiles of women with anal neoplasia associated with cervical neoplasia attending a tertiary healthcare facility in northeastern Brazil. Methods: This epidemiological, descriptive study was conducted using a database from a cross-sectional study carried out between December 2008 and January 2016. Women with a diagnosis of cervical neoplasia associated with anal neoplasia were included in the present study. Results: Of the women with cervical neoplasia, 14% were found to have an anal intraepithelial lesion or anal cancer. Median age was 33 years, 68% were non-white, and 70% were from urban regions, had little schooling and low income. Most reported having had anoreceptive (73%) and unprotected intercourse (84%). Regarding symptoms, 7% reported bleeding and 11% pruritus. Overall, 10% of the sample tested positive for the human immunodeficiency virus. Anal cytology was abnormal in 92%. High-resolution anoscopy was abnormal in all cases. Histopathology revealed three cases of invasive carcinoma and high-grade lesions in 32% of the cases. Conclusion: Women with a diagnosis of anal and cervical neoplasia are often young, non-white women, who initiated their sexual life at an early age, were exposed to unprotected anoreceptive intercourse, live in urban centers, have little schooling and a low-income level.

Resumo Objetivo: Descrever os perfis epidemiológico, clínico e laboratorial de mulheres com neoplasia anal associada à neoplasia cervical atendidas em uma unidade de saúde terciária no nordeste do Brasil. Métodos: Este estudo epidemiológico e descritivo usou um banco de dados de um estudo transversal realizado entre dezembro de 2008 e janeiro de 2016. Mulheres com diagnóstico de neoplasia cervical associada à neoplasia anal foram incluídas no presente estudo. Resultados: Das mulheres com neoplasia cervical, 14% apresentaram lesão intra-epitelial anal ou câncer anal. A mediana de idade foi de 33 anos; 68% das pacientes não eram brancas e 70% eram provenientes de regiões urbanas, com baixa escolaridade e baixa renda. A maioria relatou histórico de relações sexuais anoreceptivas (73%) e desprotegidas (84%). Quanto aos sintomas, 7% relataram sangramento e 11% prurido. No geral, 10% das pacientes apresentaram serologia positiva para o vírus da imunodeficiência humana. A citologia anal foi anormal em 92% da amostra. A anuscopia de alta resolução foi anormal em todos os casos. A histopatologia revelou três casos de carcinoma invasivo e lesões de alto grau em 32% dos casos. Conclusão: As mulheres com diagnóstico de neoplasia anal e cervical geralmente são jovens, não brancas, que iniciaram sua vida sexual em idade precoce, foram expostas a relações sexuais anoreceptivas desprotegidas, moram em centros urbanos e têm baixa escolaridade e baixo nível de renda.

Complex reconstruction of the perineal and gluteal regions after resection of a large squamocellular carcinoma of the anal margin: a case report / Reconstrução complexa de regiões glútea e perineal após ressecção de extenso carcinoma escamocelular de borda anal: relato de caso

Perineal and gluteal regions may be affected by a wide spectrum of diseases, and the treatment may require extensive surgery and cause functional, aesthetic, and psychosocial damages at various levels. Wounds in the extensive perineal and gluteal regions after surgical treatment of neoplasia may represent a challenge in local reconstruction. Size, location, and availability of tissue around the lesion may hinder wound primary closure, requiring the use of one or more flaps. This article reports a case of reconstruction of the perineal and gluteal regions after oncological resection at the plastic surgery service of the Hospital das Clínicas at the Federal University of Minas Gerais. The muscle and fasciocutaneous flaps of the gluteus maximus and myocutaneous of the semimembranosus were used.

As regiões glútea e perineal podem ser afetadas por um variado espectro de doenças, cujo tratamento pode demandar extensas mutilações e acarretar em prejuízo funcional, estético e psicossocial em variados graus. Feridas extensas da região perineal e glútea após o tratamento cirúrgico de neoplasias podem representar um desafio para a reconstrução local. Tamanho, localização e disponibilidade de tecido em torno da lesão são fatores que podem impedir o seu fechamento primário, tornando necessário o uso de um ou mais retalhos. Este artigo relata um caso de reconstrução de períneo e região glútea após ressecção oncológica, no serviço de Cirurgia Plástica do Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG). Foram utilizados os retalhos muscular e fasciocutâneo de glúteo máximo e miocutâneo de semimembranoso.

Value of conventional cytology in the presence of macroscopic lesions of the anal canal / Valor da citologia convencional na presença de lesões macroscópicas do canal anal

OBJECTIVES: To verify the value of conventional cytology for the diagnosis of macroscopic lesions of the anal canal and to describe the limitations of the samples. METHOD: We evaluated 395 conventional cytology samples obtained by brushing the anal canal of patients (predominantly male, HIV-positive) and compared them to the presence of macroscopic lesions of the anal canal observed under anorectal examination. RESULTS: Of the total, 91.6% of samples were classified as adequate. Cellular elements representative of the anal transformation zone were observed in 63.5% of samples. Sensitivity in the presence or absence of cellularity was 80% and 31%, respectively. CONCLUSION: The study demonstrates the feasibility of using conventional anal cytology in outpatients. (AU)

OBJETIVO: verificar o valor da citologia convencional no diagnóstico de lesões macroscópicas do canal anal e descrever as limitações das amostras obtidas. MÉTODO: avaliamos 395 exames citológicos convencionais obtidos por escovado do canal anal de pacientes predominantemente do sexo masculino, soropositivos para HIV, e comparamos com a presença de lesões macroscópicas do canal anal constatadas ao exame proctológico. RESULTADO: o percentual de amostras adequadas foi de 91,6%, e os elementos celulares representativos da zona de transformação anal foram observados em 63,5% das amostras. Encontramos sensibilidade de 80% e 31% na presença ou ausência desta celularidade, respectivamente. CONCLUSÃO: O estudo demonstra a possibilidade de utilização da citologia anal convencional no rastreio de lesões macroscópicas do canal anal em pacientes ambulatoriais. (AU)

Indicação da anuscopia de alta resolução e citologia anal na prevenção de HPV e câncer colorretal em pacientes portadores de HIV / Indication of high resolution anoscopy and anal cytology for prevention of HPV and colorectal cancer in HIV patients

OBJETIVO: Rastreamento do papilomavírus humano (HPV) assim como sua correlação com a neoplasia anorretal nos pacientes portadores do vírus da imunodeficiência humana (HIV) por meio da anuscopia de alta resolução (AAR) e da citologia anal. MÉTODOS: Desenvolvemos um estudo observacional, transversal e duplo-cego em que participaram 31 pacientes portadores do HIV independente de queixas proctológicas. Os pacientes foram submetidos à AAR e citologia anal cujas lâminas foram enviadas ao setor de anatomia patológica para coloração e posterior análise. RESULTADOS: Verificamos 22 pacientes do sexo masculino e 9 do sexo feminino entre 20 e 67 anos. Dos 31 analisados, quatro encontravam-se em estágio de imunodepressão, 23 utilizavam terapia antirretroviral, 16 com passado de sexo anal receptivo e 12 com passado de condiloma acuminado. À AAR 11 pacientes tinham alterações e 7 foram confirmados pela citologia. Verificamos ainda oito pacientes com alterações à citologia os quais possuíam ausência de alterações à AAR. À citologia apresentaram três células escamosas atípicas de significância (Ascus, do inglês atypical squamous cells of undetermined significance), cinco com paraceratose e/ou hiperceratose, seis lesões intraepiteliais de baixo grau e uma lesão intraepitelial de alto grau. CONCLUSÃO: Sugerimos a utilização da AAR aliada à citologia anal para rastreamento nos pacientes portadores do HIV, visto que esses exames complementam-se para a detecção de lesões que estejam relacionadas ao câncer anorretal.

OBJECTIVE: Screening for HPV as well as its correlation with anorectal cancer in patients carrying the human immuno deficiency virus (HIV) through high-resolution anoscopy (HRA) and anal cytology. METHODS: We developed an observational study, double-blind attended by 31 patients with HIV independent proctologic complaints. Patients underwent HRA and anal cytology slides were sent to which sector pathology staining and analysis. RESULTS: We found 22 males and 9 females between 20 and 67 years. Of the 31 tested, 4 were in stage of immunosuppression, 23 were using antiretroviral therapy, 16 with history of receptive anal sex and 12 with a history of condyloma acuminata. In the HRA 11 patients had changes and 7 were confirmed by cytology. We also verified eight patients with abnormal cytology who had no changes to the HRA. In the atypical squamous cells of undetermined significance (Ascus) cytology had three, five with parakeratosis and/or hyperkeratosis, six intraepithelial lesions and a low grade squamous intraepithelial lesion high grade. CONCLUSION: We suggest the use of anoscopy high resolution combined with anal cytology for screening in patients with the HIV, since these examinations are complementary for the detection of lesions that are related to anorectal cancer.