Eosinophilic Annular Erythema in a Patient with Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) / 대한피부과학회지

No abstract available.

A Case of Eosinophilic Annular Erythema / 대한피부과학회지

Eosinophilic annular erythema (EAE) is a rare, recurrent disease of unknown etiology with tissue eosinophilia that was initially reported in a pediatric patient. It is debatable whether EAE is a distinct disease entity or a subtype of Well's syndrome. Clinically, EAE is characterized by annular erythematous plaques lasting for 4 to 12 months that predominantly affect the trunk and proximal extremities. Histologically, dense superficial and deep perivascular inflammatory infiltrates composed of lymphocytes and abundant eosinophils are observed. Herein, we report a case of EAE in a 21-year-old Korean female. The patient visited our clinic with a 1-year history of multiple erythematous annular patches on both legs that became worse during the summer and between seasons. Histopathologic examination demonstrated superficial and deep perivascular, periadnexal, and interstitial infiltrates of lymphocytes and eosinophils in the dermis and the subcutaneous fat layer. Based on the clinical and histological features, the case was diagnosed as eosinophilic annular erythema.

A Case of Erythema Nodosum Migrans / 대한피부과학회지

No abstract available.

Annular Erythema of Infancy / 대한피부과학회지

No abstract available.

Immunohistochemical Analysis of Interleukin-17 Producing T Helper Cells and Regulatory T Cells Infiltration in Annular Erythema Associated with Sjogren's Syndrome

BACKGROUND: Peculiar erythema known as annular erythema associated with Sjogren's syndrome (AESS) can be differentiated from autoimmune annular erythema and subacute cutaneous lupus erythematosus, both clinically and histologically. However, there are no detailed investigations on immune competent cells infiltration. OBJECTIVE: Preferential infiltration of interleukin-17-producing T helper (Th17) cells and regulatory T (Treg) cells into the labial salivary gland is reported to play a role in maintaining mucoepithelitis in patients with Sjogren's syndrome. In this study, we evaluated Th17 and Treg cell infiltration into the lesional skin of AESS. METHODS: We analyzed the numbers and infiltration patterns of Th17 and FoxP3 (+) Treg cells in seven cases of AESS using immunohistochemistry. Seven patients with systemic lupus erythematosus (SLE), atopic dermatitis (AD) and psoriasis vulgaris (PV), which are representatives of Th17 cell-involved skin disorders, were enrolled as disease controls. RESULTS: Periappendageal and epidermal changes, such as follicular plugging and liquefaction, were evident in the annular erythema of SLE, not AESS, tissue samples. In AESS tissue samples, dense perivascular and periappendageal infiltration of lymph cells was observed in the middle-to-deep dermis, as previously described, in contrast to the superficial infiltration pattern observed in both AD and PV samples. While the total number of infiltrated lymphocytes was similar between AESS and SLE tissue samples, Th17 cells were found to be preferentially infiltrated in the middle-to-deep dermis in AESS samples. CONCLUSION: These results suggest that an increased number and distribution of infiltration of Th17 cells is a preferential feature of AESS, rather than a characteristic feature of annular erythema of SLE.

A Case of Recurrent Annular Erythema of Sjogren's Syndrome Treated with Hydroxychloroquine / 대한피부과학회지

No abstract available.

Annular Erythema Associated with Anti-Ro/La Antibody Occurring in Plantar Area / 대한피부과학회지

Recurrent annular erythema associated with anti-Ro/La antibody is a diagnostic term for annular erythemas that usually occurs in the face and the upper extremities of patients with positive anti-Ro/La antibodies. They have been reported in patients with Sjogren's syndrome, lupus erythematosus, or Sjogren's syndrome/systemic lupus erythematosus syndrome. Recently, there have been cases without any underlying autoimmune diseases. We, hereby, report an annular erythema, associated with anti-Ro/La antibody occurring in both soles, which is an unusual location for this disease.

Primary Sjogren's Syndrome Manifested asAnnular Erythema and Fever of an Unknown Origin / 대한피부과학회지

Sjogren's syndrome is an autoimmune disorder that's characterized by dry eyes and dry mouth, and this is due to lymphocytic infiltration of the lacrimal and salivary glands. The skin lesions in Sjogren's syndrome usually manifest with xeroderma, pruritus and pigmentation, but sometimes the lesions appear as annular erythema. Patients with Sjogren's syndrome rarely display fever, with the exception of the cases that show complicated illness such as lymphoma. We report here on a case of a 27-year-old woman who was diagnosed with Sjogren's syndrome, and she showed signs of annular erythema and a fever of an unknown origin.

Primary Sjogren's Syndrome Manifested asAnnular Erythema and Fever of an Unknown Origin / 대한피부과학회지

Sjogren's syndrome is an autoimmune disorder that's characterized by dry eyes and dry mouth, and this is due to lymphocytic infiltration of the lacrimal and salivary glands. The skin lesions in Sjogren's syndrome usually manifest with xeroderma, pruritus and pigmentation, but sometimes the lesions appear as annular erythema. Patients with Sjogren's syndrome rarely display fever, with the exception of the cases that show complicated illness such as lymphoma. We report here on a case of a 27-year-old woman who was diagnosed with Sjogren's syndrome, and she showed signs of annular erythema and a fever of an unknown origin.

A Case of Familial Annular Erythema / 대한피부과학회지

The cause of most cases of erythema annulare centrifugum (EAC) is unknown. There have been extremely rare reports, clinicopathologically compatible with EAC, occurring in a family. A case of annular erythema, which was indistinguishable from EAC, occurred in a 5-month-old girl and her mother. We propose to consider this a separate entity, `familial annular erythema', rather than take into any familial cause of EAC.

Recurrent Annular Erythema in the Patients with Sj gren's Syndrome and/or Lupus Erythematosus-like Features / 대한피부과학회지

BACKGROUND: Recurrent annular erythema associated with anti-Ro (SSA) or anti-La (SSB) antibodies has been recognized as a unique cutaneous manifestation of Sj gren's syndrome or Sj gren's syndrome/SLE overlap syndrome in Orientals. OBJECTIVE: The purpose of this study was to evaluate the clinical, histological and serological aspects of recurrent annular erythema in the korean patients with Sj gren's syndrome and/or lupus erythematosus-like features. METHODS: This clinical investigation was carried out on 6 outpatients with this disorder who had visited Department of Dermatology, Seoul National University Hospital, from January 1996 to December 2003. RESULTS: These patients (four females, two males; range of age, 24-60 years, median 45 years) had relatively well demarcated annular erythematous plaques mainly on trunk and extremities. Two-thirds of the patients were anti-Ro positive and one-third was anti-La positive. Biopsy specimens revealed a moderate degree of perivascular and periappendageal lymphocytic infiltration throughout dermis. Other features to suggest LE were not demonstrated. Four patients were treated with oral hydroxychloroquine with good response. CONCLUSION: Although all 6 patients showed annular erythema associated with anti-Ro or anti-La antibodies, only two could be diagnosed as Sj gren's syndrome/SLE overlap syndrome. The other four presented with LE-like features such as photosensitivity, nephropathy and arthralgia.

Clinical constellation of annular erythema associated with anti-Ro/La autoantibodies

Annular erythema (AE) associated with anti-Ro (SSA) and/or La (SSB) autoantibody in patients with Sjogren syndrome (SS) or with SS/systemic lupus erythematosus overlap syndrome (SS/SLE), has recently been described in Orientals, and it may be a counterpart of annular skin lesion of the subacute cutaneous LE seen mostly in Caucasians. The author examined five Korean AE patients in respect to dinical diversity. In this small-sample study, subtle differences appeared between individual cases regarding the serologic features and the diagnoses of the disease. Among the five cases, four had circulating anti-Ro and anti-La antibodies, and one had only anti-La. Regarding the diagnosis, one was SS/SLE, two were primary SS, and the remaining two were only "AE associated with anti-Ro/La antibody". There seem to be a wide clinical spectrum in the disease expression of AE associated with anti-Ro/La autoantibody than previously thought.

Two Cases of Annular Erythema Associated with Anti-Ro/La Autoantibodies / 대한피부과학회지

Recent studies have demonstrated that annular erythema(AE) associated with anti-Ro(SSA) and/or La(SSB) autoantibodies as a unique cutaneous manifestation of Sj gren syndrome(SS) or SS/systemic lupus erythematosus(SLE) overlap syndrome in Orientals. We report two cases of annular erythemas who had anti-Ro/La antibodies in a setting of SS/SLE overlap syndrome and in a case of anti-La antibody alone with no underlying autoimmune disease, respectively. It appears that the AE may not be a rarely encountering cutaneous lesions among Korean/Oriental people.

A Case of Subacute Cutaneous Lupus Erythematosus / 대한피부과학회지

We present a case of subacute cutaneous lupus erythematosus which fulfilled the criteria of systemic lupus erythematosus in a 52-year-old woman with annular and polycyclic erythematous patches on the neck and upper part of the anterior chest. She complained malar of resh, arthralgia, general weakness, and severe headache. Laboratory findings showed hematologic, serologic, central nervous system, and nephrologic abnormalities. Serologic abnormalities of this patient were positive anti-nuclear antibody, anti-La antibody, rhematoid factor, anti-RNP antibody and anti-platelet antibody, but anti-dsDNA and anti-Ro antibody test were negative. She was treated with oral prednisolone and intravenous cyclophosphamide. In the course of treatment, sepsis developed and she died from multi-organ system failure.

Recurrent Annular Erythema in A Patient Presumed to Have Lupus Erythematosus / 대한피부과학회지

Annular erythema associated with lupus erythematosus/ Sjogrens syndrome has recently been described in Orientals. We present a patient with recurrent annular erythema who partially demonstrated features of lupus erythematosus. A 32-year-old man was referred to us for recurrent annular erythema. Laboratory findings revealed mild leukopenia and the presence of antinuclear antibodies at a titer of 320 with a finely speckled pattern on Hep-2 substrates. Anti-Ro/La antibodies were also detected. A skin biopsy specimen revealed the findings of perivascular and periappendageal lymphocytic infiltration without prominent hydropic degeneration of the basal layer. Skin lesions subsided with hydroxychloroquine (400-200mg/day).