Anti-GM1 Antibody Associated Acute Motor Conduction Block Neuropathy Presenting With Reversible Conduction Failure

A 57-year-old man developed motor weakness and paresthesia after acute enteritis. Nerve conduction study revealed decreased compound muscle action potentials in median nerves and conduction blocks in ulnar nerves. Serum IgG anti-GM1 antibody was positive. Conduction blocks rapidly disappeared through sequential studies, which are defined as reversible conduction failure (RCF). This study represents anti-GM1 antibody-associated acute motor conduction block neuropathy based on RCF. We underline that serial nerve conduction studies might be required for characterization of clinical and electrophysiological features.

A Case of Acute Motor Axonal Type Guillain-Barr Syndrome with Anti-GM1 Antibody and Anti-GD1 Antibody / 대한소아신경학회지

Acute motor axonal Guillain-Barr syndrome is a paralytic disorder of abrupt onset, characterized electrophysiologically by near-normal terminal latencies, preserved nerve conduction velocity with low CAMP amplitude without a conduction block, and early appearing nerve inexcitability and by sparing sensory fibers. Most cases have antecedental infection with Campylobacter jejuni and have antibodies directed toward GM1 ganglioside-like epitopes. We have experienced a case of primary axonal type of Guillain-Barr syndrome in a 14-year-old female patient, who has symptoms of difficulty in swallowing and progressive flaccid paralysis associated with anti-GM1 antibody and anti-GD1 antibody.